M<scp>EGALIN</scp>- <scp>AND</scp> C<scp>UBILIN</scp>-M<scp>EDIATED</scp> E<scp>NDOCYTOSIS OF</scp> P<scp>ROTEIN</scp>-B<scp>OUND</scp> V<scp>ITAMINS</scp>, L<scp>IPIDS</scp>, <scp>AND</scp> H<scp>ORMONES IN</scp> P<scp>OLARIZED</scp> E<scp>PITHELIA</scp>

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Endocytosis

1997 • 1,263 citations

An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3

1999 • 989 citations

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.

1994 • 550 citations

Clathrin

2000 • 528 citations

Defective forebrain development in mice lacking gp330/megalin.

1996 • 485 citations

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

1992 • 466 citations

Transepithelial Transport of Immunoglobulins

1994 • 457 citations

Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria

1999 • 432 citations

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.

1995 • 338 citations

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module

1997 • 329 citations

Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP).

1994 • 323 citations

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

2000 • 312 citations

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

1996 • 274 citations

The intrinsic factor–vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein

1999 • 268 citations

Development, morphology, and function of the yolk‐sac placenta of laboratory rodents

1990 • 267 citations

Megalin/gp330 mediates uptake of albumin in renal proximal tubule

1996 • 263 citations

Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1

1999 • 260 citations

Knockout of the abetalipoproteinemia gene in mice: Reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes

1998 • 258 citations

The Intrinsic Factor-Vitamin B12 Receptor and Target of Teratogenic Antibodies Is a Megalin-binding Peripheral Membrane Protein with Homology to Developmental Proteins

1998 • 254 citations

Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol

1999 • 238 citations

Selective Vitamin B₁₂ Malabsorption and Proteinuria in Young People A Syndrome

1960 • 227 citations

Identification of Glycoprotein 330 as an Endocytic Receptor for Apolipoprotein J/Clusterin

1995 • 220 citations

Lipoprotein receptors: new roles for ancient proteins

1999 • 218 citations

Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis.

1996 • 211 citations

Tissue Distribution of Human gp330/Megalin, a Putative Ca²⁺-sensing Protein

1997 • 191 citations

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

1992 • 190 citations

Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands.

1998 • 183 citations

Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin

1995 • 181 citations

Idiopathic Chronic Megaloblastic Anemia in Children

1960 • 174 citations

Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes

1993 • 169 citations

Membrane Receptors for Endocytosis in the Renal Proximal Tubule

1998 • 169 citations

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

2000 • 162 citations

The Human Intrinsic Factor-Vitamin B12 Receptor,Cubilin: Molecular Characterization and Chromosomal Mapping of the Gene to 10p Within the Autosomal Recessive Megaloblastic Anemia (MGA1) Region

1998 • 161 citations

Megalin is an endocytic receptor for insulin.

1998 • 160 citations

Characterization of an Epithelial ∼460-kDa Protein That Facilitates Endocytosis of Intrinsic Factor-Vitamin B12 and Binds Receptor-associated Protein

1997 • 157 citations

Cubilin, the endocytic receptor for intrinsic factor-vitamin B ₁₂ complex, mediates high-density lipoprotein holoparticle endocytosis

1999 • 154 citations

Cloning and Sequencing of Human gp330, a Ca²⁺‐Binding Receptor with Potential Intracellular Signaling Properties

1996 • 151 citations

Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules.

1995 • 149 citations

A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice

1996 • 148 citations

Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein.

1992 • 147 citations

Megalin Acts in Concert with Cubilin to Mediate Endocytosis of High Density Lipoproteins

2000 • 144 citations

gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex.

1992 • 141 citations

Structural and functional features of protein handling in the kidney proximal tubule.

1991 • 140 citations

Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies.

1988 • 137 citations

Myeloma light chains are ligands for cubilin (gp280)

1998 • 131 citations

Molecular Dissection of the Intrinsic Factor-Vitamin B12 Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding

1999 • 129 citations

Evidence for the Role of Megalin in Renal Uptake of Transthyretin

2000 • 126 citations

Inherited Selective Intestinal Cobalamin Malabsorption and Cobalamin Deficiency in Dogs

1991 • 126 citations

Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro

1993 • 124 citations

Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor.

1997 • 121 citations

A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans.

1993 • 114 citations

Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption

1991 • 106 citations

Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100

1995 • 103 citations

Receptor-Associated Protein Is Important for Normal Processing of Megalin in Kidney Proximal Tubules

2000 • 103 citations

Immunological localization of glycoprotein 330, low density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic mouse tissues.

1994 • 98 citations

A Protein Involved in Calcium Sensing of the Human Parathyroid and Placental Cytotrophoblast Cells Belongs to the LDL-Receptor Protein Superfamily

1994 • 97 citations

The preendosomal compartment comprises distinct coated and noncoated endocytic vesicle populations.

1991 • 97 citations

Regulation of gp330/megalin expression by vitamins A and D

1998 • 95 citations

beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin.

1998 • 94 citations

Purification, properties, and immunochemical localization of a receptor for intrinsic factor-cobalamin complex in the rat kidney.

1988 • 90 citations

Role of Megalin (gp330) in Transcytosis of Thyroglobulin by Thyroid Cells

2000 • 88 citations

Interaction of C1q and the Collectins with the Potential Receptors Calreticulin (cClqR/Collectin Receptor) and Megalin

1998 • 88 citations

Trichosanthin Interacts with and Enters Cells via LDL Receptor Family Members

2000 • 83 citations

Transferrin receptor distribution and regulation in the rat small intestine

1990 • 79 citations

Role of thyroglobulin endocytic pathways in the control of thyroid hormone release

2000 • 75 citations

Megalin (gp330): A Putative Endocytic Receptor for Thyroglobulin (Tg)

1998 • 74 citations

Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor–ligand interactions

1997 • 73 citations

Experimental yolk sac dysfunction as a model for studying nutritional disturbances in the embryo during early organogenesis

1990 • 71 citations

gp330 on type ii pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex

1995 • 71 citations

Identification of Megalin/gp330 as a Receptor for Lipoprotein(a) In Vitro

1999 • 71 citations

Identification of the Minimal Functional Unit in the Low Density Lipoprotein Receptor-related Protein for Binding the Receptor-associated Protein (RAP)

2000 • 68 citations

Cell physiology of the rat visceral yolk sac: A study of pinocytosis and lysosome function

1990 • 64 citations

Cubilin, a high-density lipoprotein receptor

2000 • 64 citations

Megalin-Mediated endocytosis in renal proximal tubule

1998 • 64 citations

Megalin (gp330) Is an Endocytic Receptor for Thyroglobulin on Cultured Fisher Rat Thyroid Cells

1999 • 61 citations

Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development

1999 • 60 citations

Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor–vitamin B12 by cubilin

2000 • 60 citations

Low Density Lipoprotein Receptor-Related Protein-2 Expression in Efferent Duct and Epididymal Epithelia: Evidence in Rats for its in Vivo Role in Endocytosis of Apolipoprotein J/Clusterin1

1996 • 57 citations

Genetic Evidence of an Accessory Activity Required Specifically for Cubilin Brush-Border Expression and Intrinsic Factor-Cobalamin Absorption

1999 • 53 citations

Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells.

1993 • 52 citations

The expression of megalin (gp330) and LRP diverges during F9 cell differentiation

1995 • 49 citations

Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER

1993 • 46 citations

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

2000 • 40 citations

Coexpression in humans by kidney and fetal envelopes of a 280 kDa-coated pit-restricted protein. Similarity with the murine target of teratogenic antibodies.

1992 • 39 citations

Cubilin expression and posttranslational modification in the canine gastrointestinal tract

2000 • 27 citations

Megalin (gp330): A Putative Endocytic Receptor for Thyroglobulin (Tg)

1998 • 26 citations

Internalization and recycling of glycoprotein 280 in epithelial cells of yolk sac.

1997 • 26 citations

Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubule.

1997 • 25 citations

Synthesis and secretion of Cobalamin binding proteins by opossum kidney cells

1991 • 24 citations

Nutritional role of the visceral yolk sac in organogenesis-stage rat embryos

1998 • 22 citations

Effect of Processing Inhibitors on Cobalamin (Vitamin B12) Transcytosis in Polarized Opossum Kidney Cells

1994 • 21 citations

Characterization of the N-linked oligosaccharides of megalin (gp330) from rat kidney

2000 • 19 citations

Unusual Processing of gp280, a Protein Associated with the Intermicrovillar Areas of Yolk Sac Epithelial Cells: Plasma Membrane Delivery of Immature Protein

1995 • 18 citations

Identification of Low Density Lipoprotein Receptor-related Protein-2/megalin as an Endocytic Receptor for Seminal Vesicle Secretory Protein II

1999 • 16 citations

Leupeptin and ammonium chloride inhibit intrinsic factor mediated transcytosis of [57Co]cobalamin across polarized renal epithelial cells

1992 • 16 citations

Megalin in normal tissues and carcinoma cells carries oligo/poly alpha2,8 deaminoneuraminic acid as a unique posttranslational modification.

1999 • 15 citations

Glycoprotein 330 and low density lipoprotein receptor-related protein mediate internalization of prourokinase and complexes of urokinase with pai-1 in type II pneumocytes

1994 • 3 citations