CYP17 Gene Polymorphisms: Prevalence and Associations with Hormone Levels and Related Factors. A HuGE Review

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17

1994 • 467 citations

Cloning and Sequence of the Human Gene for P450cl7 (Steroid 17α-Hydroxylase/17,20 Lyase): Similarity with the Gene for P450c21

1987 • 415 citations

Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease Associations

2002 • 377 citations

Reproductive Hormones in the Early Menopausal Transition: Relationship to Ethnicity, Body Size, and Menopausal Status

2003 • 354 citations

Use of Hormone Replacement Therapy by Postmenopausal Women in the United States

1999 • 331 citations

Association between Plasma Total Testosterone and Cardiovascular Risk Factors in Healthy Adult Men: The Telecom Study¹

1997 • 309 citations

Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility.

1999 • 299 citations

Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom).

2001 • 287 citations

Testosterone, body composition and aging.

1999 • 278 citations

Some endocrine characteristics of early menarche, a risk factor for breast cancer, are preserved into adulthood

1989 • 256 citations

A polymorphism in the CYP17 gene increases the risk of breast cancer.

1997 • 250 citations

Lower endogenous androgens predict central adiposity in men

1992 • 247 citations

Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations.

1998 • 243 citations

Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study.

2002 • 236 citations

The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer.

1999 • 228 citations

Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2)

1999 • 212 citations

Association between Plasma Total Testosterone and Cardiovascular Risk Factors in Healthy Adult Men: The Telecom Study

1997 • 204 citations

Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men

1992 • 195 citations

Hormonal Markers and Hepatitis B Virus-Related Hepatocellular Carcinoma Risk: a Nested Case-Control Study Among Men

2001 • 176 citations

CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1.

1999 • 154 citations

Increased risk of prostate cancer and benign prostatic hyperplasia associated with a CYP17 gene polymorphism with a gene dosage effect.

2000 • 153 citations

Tissue-Specific, Cyclic Adenosine 3′,5′-Monophosphate-lnduced, and Phorbol Ester-Repressed Transcription from the Human P450c17 Promoter in Mouse Cells

1990 • 122 citations

Prostate cancer associated with CYP17 genotype

1999 • 119 citations

No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer

1998 • 118 citations

The Risk of Breast Cancer Associated with Dietary Lignans Differs by CYP17 Genotype in Women

2002 • 112 citations

Relationship between serum hormone concentrations, reproductive history, alcohol consumption and genetic polymorphisms in pre‐menopausal women

2002 • 109 citations

Association betweenCYP17 gene polymorphism and risk of breast cancer in young women

1999 • 108 citations

The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer.

2003 • 108 citations

Estrogen-Metabolizing Gene Polymorphisms, But Not Estrogen Receptor-α Gene Polymorphisms, Are Associated with the Onset of Menarche in Healthy Postmenopausal Japanese Women

2003 • 107 citations

17α-Hydroxylase/17,20-lyase defects

1995 • 103 citations

Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates.

2001 • 101 citations

Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women

2002 • 97 citations

CYP17 genotype and breast cancer risk.

1998 • 97 citations

A polymorphism in the CYP17 gene is associated with male breast cancer

1999 • 96 citations

Association between CYP17 polymorphisms and the development of breast cancer.

1998 • 95 citations

Polymorphism T→C (−34 bp) of gene CYP17 promoter in Greek patients with polycystic ovary syndrome

1999 • 92 citations

The association between polymorphisms in the CYP17 and 5alpha-reductase (SRD5A2) genes and serum androgen concentrations in men.

2001 • 90 citations

Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men

1992 • 90 citations

Steroid metabolism gene CYP17 polymorphism and the development of breast cancer.

2000 • 88 citations

A polymorphism in CYP17 and endometrial cancer risk.

2001 • 87 citations

Serum Androgen Concentrations in Young Men: A Longitudinal Analysis of Associations with Age, Obesity, and Race.

2002 • 85 citations

The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer.

2001 • 83 citations

Reliability of serum hormones in premenopausal and postmenopausal women over a one-year period.

1996 • 82 citations

CYP Gene Polymorphisms and Early Menarche

2001 • 81 citations

Genetic determinants of mammographic density

2002 • 81 citations

FDA Orders Estrogen Safety Warnings

2003 • 79 citations

A polymorphism in the CYP17 gene and risk of prostate cancer.

2002 • 78 citations

Cyp17 promoter variant associated with prostate cancer aggressiveness in African Americans.

2001 • 77 citations

Cytochrome P450c17alpha gene (CYP17) polymorphism predicts use of hormone replacement therapy.

1999 • 71 citations

CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors

2003 • 71 citations

CYP17 Promoter Polymorphism and Breast Cancer in Australian Women Under Age Forty Years

2000 • 69 citations

Significant ethnic variation in total and free testosterone concentration

2003 • 65 citations

Frequency of a polymorphism in the regulatory region of the 17α‐hydroxylase‐17,20‐lyase (CYP17) gene in hyperandrogenic states

1997 • 64 citations

HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore

2003 • 64 citations

Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17α-hydroxylase/C17-20 lyase promoters

2002 • 63 citations

A Common Promoter Variant in the Cytochrome P450c17α (CYP17) Gene Is Associated with Bioavailable Testosterone Levels and Bone Size in Men

2001 • 62 citations

Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer.

2002 • 59 citations

Genetic polymorphism in CYP17 and breast cancer risk in Japanese women

2000 • 56 citations

Sex hormones and adipose tissue distribution in premenopausal cigarette smokers.

1992 • 54 citations

Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer

2001 • 54 citations

Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women

2002 • 50 citations

CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 status

2003 • 45 citations

The epidemiology and endocrinology of the menarche in relation to breast cancer.

1986 • 44 citations

CYP17 promotor polymorphism and ovarian cancer risk

2000 • 44 citations

Determinants of sex hormone‐binding globulin in normal postmenopausal women

2001 • 42 citations

Risk of endometrial cancer and estrogen replacement therapy history by CYP17 genotype.

2001 • 41 citations

No Association of the 5′Promoter Region Polymorphism of CYP17 with Breast Cancer Risk in Japan

2000 • 37 citations

Hypersecretion of androgens by polycystic ovaries: The role of genetic factors in the regulation of cytochrome P450c17α

1996 • 36 citations

CYP17 polymorphism in the groups of distinct breast cancer susceptibility: comparison of patients with the bilateral disease vs. monolateral breast cancer patients vs. middle-aged female controls vs. elderly tumor-free women

2000 • 33 citations

The optimal timing of blood collection during the menstrual cycle for the assessment of endogenous sex hormones: can interindividual differences in levels over the whole cycle be assessed on a single day?

2002 • 25 citations

Regressive logistic and proportional hazards disease models for within‐family analyses of measured genotypes, with application to a CYP17 polymorphism and breast cancer

2003 • 23 citations

Allelic frequencies of six polymorphic markers for risk of prostate cancer

2002 • 22 citations

CYP17 genotype and ovarian cancer: a null case-control study.

2001 • 21 citations

Investigations on the genetic polymorphism in the region of CYP17 gene encoding 5'-UTR in patients with polycystic ovarian syndrome

2001 • 19 citations

Association of CYP17 genetic polymorphism with intra-tumoral estradiol concentrations but not with CYP17 messenger RNA levels in breast cancer tissue

2002 • 18 citations

No association of the 5′ promoter region polymorphism of CYP17 gene with prostate cancer risk

2002 • 16 citations

Possible association of CYP17 gene polymorphisms with the onset of rheumatoid arthritis.

1999 • 14 citations

Women’s Health and Menopause: A Comprehensive Approach

2002 • 12 citations

Use of hormonal therapy for menopause in nine European countries.

2002 • 11 citations

Prostate cancer associated with CYP17 genotype

1999 • 10 citations

Association Between Smoking, Acetaldehyde Dehydrogenase-2 1-1 Status, and Alcohol Drinking Among Taiwanese Polyvinyl Chloride Workers

2001 • 4 citations

Association between CYP17 gene polymorphism and risk of breast cancer in young women

1999 • 4 citations

No association of the 5′ promoter region polymorphism of CYP17 gene with prostate cancer risk

2002 • 1 citations