The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer.

Variations in pattern of pubertal changes in girls.

1969 • 5,491 citations

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 • 2,120 citations

Secondary Sexual Characteristics and Menses in Young Girls Seen in Office Practice: A Study from the Pediatric Research in Office Settings Network

1997 • 1,692 citations

Functional role of estrogen metabolism in target cells: review and perspectives

1998 • 965 citations

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

1999 • 722 citations

RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1999 • 478 citations

Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17

1994 • 467 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Ethnic Differences in the Presence of Secondary Sex Characteristics and Menarche Among US Girls: The Third National Health and Nutrition Examination Survey, 1988–1994

2002 • 386 citations

Association of CYP 3 A 4 genotype with treatment-related leukemia

1998 • 315 citations

Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory Region

1999 • 302 citations

CYP3A activity in African American and European American men: Population differences and functional effect of the CYP3A4*1B 5′-promoter region polymorphism

2000 • 250 citations

Population distribution and effects on drug metabolism of a genetic variant in the 5′ promotor region of CYP3A4

1999 • 237 citations

Chapter 1: Developmental, Cellular, and Molecular Basis of Human Breast Cancer

2000 • 235 citations

Pubertal development in Swiss girls.

1983 • 192 citations

Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients.

1999 • 190 citations

Body fat mass, body fat distribution, and pubertal development: a longitudinal study of physical and hormonal sexual maturation of girls.

1992 • 185 citations

Histological characteristics of breast carcinoma in blacks and whites.

1994 • 183 citations

Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16[alpha ]-hydroxylation of 17[beta ]-estradiol

2001 • 176 citations

Altered estrogen metabolism and excretion in humans following consumption of indole‐3‐carbinol

1991 • 155 citations

Western nutrition and the insulin resistance syndrome: A link to breast cancer

1999 • 128 citations

A rare CYP19 (aromatase) variant may increase the risk of breast cancer

1998 • 123 citations

Determinants of age at menarche as early life predictors of breast cancer risk

1996 • 123 citations

A NESTED CASE-CONTROL STUDY OF THE CORRELATES OF EARLY MENARCHE

1990 • 119 citations

Diurnal Rhythm of Testosterone Secretion before and throughout Puberty in Healthy Girls: Correlation with 17β-Estradiol and Dehydroepiandrosterone Sulfate¹

1999 • 114 citations

Chapter 7: Molecular Epidemiology of Genetic Polymorphisms in Estrogen Metabolizing Enzymes in Human Breast Cancer

2000 • 114 citations

Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls

2000 • 112 citations

Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online.

1998 • 112 citations

Diet, body size and menarche in a multiethnic cohort

1999 • 98 citations

Can mammography screening explain the race difference in stage at diagnosis of breast cancer?

1995 • 89 citations

CYP Gene Polymorphisms and Early Menarche

2001 • 81 citations

The Effects of Cimetidine on the Oxidative Metabolism of Estradiol

1989 • 81 citations

16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5

1998 • 70 citations

Steroid hormones during puberty: racial (black-white) differences in androstenedione and estradiol--the Bogalusa Heart Study.

1992 • 59 citations

Breast Cancer among Hispanics, American Indians and Non-Hispanic Whites in New Mexico

1994 • 52 citations

Characteristics of pubertal development in a multi-ethnic population of nine-year-old girls

2004 • 38 citations

Cancer incidence in New York City Hispanics, 1982 to 1985.

1991 • 26 citations

The NECTAR-Study: development of nutrition modules for general practice vocational training; determinants of nutrition guidance practices of GP-trainees

1999 • 23 citations