Interleukin‐4 Causes Susceptibility to Invasive Pulmonary Aspergillosis through Suppression of Protective Type I Responses

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.

1992 • 1,849 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Invasive Aspergillosis

1998 • 1,458 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Neutrophils, host defense, and inflammation: a double-edged sword

1994 • 807 citations

Prolonged Granulocytopenia: The Major Risk Factor for Invasive Pulmonary Aspergillosis in Patients with Acute Leukemia

1984 • 772 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Selective Protection against Conidia by Mononuclear and against Mycelia by Polymorphonuclear Phagocytes in Resistance to Aspergillus

1982 • 624 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Pulmonary Aspergillosis in the Acquired Immunodeficiency Syndrome

1991 • 511 citations

Chronic Necrotizing Pulmonary Aspergillosis

1982 • 390 citations

Absence of Respiratory Burst in X-linked Chronic Granulomatous Disease Mice Leads to Abnormalities in Both Host Defense and Inflammatory Response to Aspergillus fumigatus

1997 • 370 citations

Fungal infection in chronic granulomatous disease

1981 • 361 citations

Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia.

1995 • 337 citations

Interleukin-10 Is a Natural Suppressor of Cytokine Production and Inflammation in a Murine Model of Allergic Bronchopulmonary Aspergillosis

1997 • 324 citations

Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.

1997 • 275 citations

Interieukin-10 Impairs Host Defense in Murine Pneumococcal Pneumonia

1996 • 262 citations

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

1997 • 251 citations

Cytokine‐ and T Helper–Dependent Lung Mucosal Immunity in Mice with Invasive Pulmonary Aspergillosis

1998 • 249 citations

Th1 and Th2 cytokines in mice with invasive aspergillosis

1997 • 216 citations

Enhancement of oxidative response and damage caused by human neutrophils to Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon

1993 • 209 citations

Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon.

1985 • 206 citations

Humoral and cell-mediated autoimmunity in allergy to Aspergillus fumigatus.

1996 • 201 citations

An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

1997 • 194 citations

Candida and Aspergillus Infections in Immunocompromised Patients: An Overview

1991 • 183 citations

B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28

1998 • 179 citations

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.

1997 • 172 citations

Endogenous Interleukin 4 Is Required for Development of Protective CD4+ T Helper Type 1 Cell Responses to Candida albicans

1998 • 159 citations

Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease.

1991 • 149 citations

IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia.

1997 • 148 citations

Regulation of neutrophil-derived IL-8: the role of prostaglandin E2, dexamethasone, and IL-4.

1993 • 137 citations

A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE.

1992 • 132 citations

IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

1994 • 126 citations

In Vivo Interferon- Therapy Augments the In Vitro Ability of Chronic Granulomatous Disease Neutrophils to Damage Aspergillus Hyphae

1991 • 121 citations

IL-10 exerts suppressive and enhancing effects on antifungal activity of mononuclear phagocytes against Aspergillus fumigatus.

1997 • 120 citations

The T cell response against fungal infections

1997 • 114 citations

Fungal Infections and Immune Responses

1993 • 105 citations

Asp f I CD4 + TH2-like T-cell lines in allergic bronchopulmonary aspergillosis

1994 • 105 citations

Impairment of Neutrophil Antifungal Activity against Hyphae of Aspergillus fumigatus in Children Infected with Human Immunodeficiency Virus

1993 • 98 citations

Interleukin-4 and its receptor: Essential mediators of the allergic response

1997 • 95 citations

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1994 • 82 citations

IFN-gamma is required for IL-12 responsiveness in mice with Candida albicans infection.

1998 • 77 citations

Initiation of T-Helper Cell Immunity to Candida albicans by IL-12: The Role of Neutrophils

1997 • 75 citations

Pulmonary host defences against Aspergillus fumigatus

1998 • 74 citations

Aspergillus fumigatusConidia Induce a Th1‐Type Cytokine Response

1997 • 74 citations

The function of costimulatory molecules and the development of IL-4-producing T cells

1997 • 73 citations

Defective co-stimulation and impaired Th1 development in tumor necrosis factor/lymphotoxin-alpha double-deficient mice infected with Candida albicans

1998 • 72 citations

Cells and cytokines in pulmonary cryptococcosis

1998 • 72 citations

Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.

1997 • 70 citations

Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor.

1993 • 65 citations

Compartmentalization of T cell responses following respiratory infection withBordetella pertussis:hyporesponsiveness of lung T cells is associated with modulated expression of the co‐stimulatory molecule CD28

1998 • 58 citations

B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.

1997 • 55 citations

Cytokine- and T-helper-dependent immunity in murine aspergillosis

1998 • 42 citations

Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.

1998 • 42 citations

Disruption of the murine IL-4 gene blocks TH2 cytokine responses

1993 • 41 citations

IL-4 induces neutrophilic maturation of HL-60 cells and activation of human peripheral blood neutrophils

1995 • 41 citations

Specific and non-specific immunity to Candida albicans a lesson from genetically modified animals

1998 • 39 citations

Immunopathologic responses to Aspergillus antigen in interleukin-4 knockout mice

1997 • 34 citations

Requirements for B7-CD28 Costimulation in Mucosal IgA Responses: Paradoxes Observed in CTLA4-Hγ1 Transgenic Mice

1998 • 33 citations

Recombinant Cytokines and Pulmonary Host Defense

1993 • 32 citations

Cytokines in allergic bronchopulmonary aspergillosis

1998 • 27 citations

Immune responses to Aspergillus antigen in IL‐4‐/‐ mice and the effect of eosinophil ablation

1999 • 27 citations

Interleukin-4 and its receptor: Essentialmediators of the allergic response

1997 • 25 citations

Aspergillus fumigatusAntigen Exposure Results in Pulmonary Airway Resistance in Wild-Type but Not in IL-4 Knockout Mice

1999 • 22 citations

The association between lung innate immunity and differential airway antigen- specific immune responses

1996 • 20 citations

Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus

1997 • 15 citations

Pulmonary Aspergillosis in a Child with Hyperimmunoglobulin E Syndrome

1998 • 15 citations

CYTOKINES IN ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS

1998 • 14 citations

Compartmentalization of T cell responses following respiratory infection with Bordetella pertussis: hyporesponsiveness of lung T cells is associated with modulated expression of the co-stimulatory molecule CD28

1998 • 13 citations