Cytokines in allergic bronchopulmonary aspergillosis

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

1991 • 472 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors.

1996 • 436 citations

T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma.

1991 • 395 citations

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

1997 • 385 citations

IL-13 expression at the sites of allergen challenge in patients with asthma.

1995 • 373 citations

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

1997 • 373 citations

Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis.

1995 • 354 citations

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

1990 • 353 citations

The human mast cell☆☆☆★

1997 • 351 citations

Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice.

1997 • 343 citations

Interleukin-10 Is a Natural Suppressor of Cytokine Production and Inflammation in a Murine Model of Allergic Bronchopulmonary Aspergillosis

1997 • 324 citations

The eosinophil as a mediator of damage to respiratory epithelium: A model for bronchial hyperreactivity

1988 • 317 citations

Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia.

1994 • 309 citations

IL-4 Induces Eotaxin: A Possible Mechanism of Selective Eosinophil Recruitment in Helminth Infection and Atopy

1998 • 301 citations

Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.

1997 • 275 citations

Mechanisms of Eosinophil Recruitment

1993 • 274 citations

Allergic bronchopulmonary aspergillosis in cystic fibrosis

1984 • 273 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice

1997 • 257 citations

Regulation and deregulation of human IgE synthesis

1990 • 254 citations

Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies

1986 • 226 citations

CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production.

1991 • 219 citations

Aspergillosis and atopy in cystic fibrosis.

1979 • 204 citations

Immunodiagnosis of aspergillosis

1991 • 202 citations

Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin.

1983 • 192 citations

Eosinophils in Allergy: Role in Disease, Degranulation, and Cytokines

1996 • 190 citations

Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines.

1997 • 183 citations

Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation.

1997 • 177 citations

Human Th1 and Th2 cells: functional properties, mechanisms of regulation, and role in disease.

1994 • 174 citations

Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins.

1990 • 167 citations

Update on cytokines

1996 • 163 citations

T cell subsets, epitope mapping, and HLA-restriction in patients with allergic bronchopulmonary aspergillosis.

1996 • 156 citations

Allergic Bronchopulmonary Aspergillosis

1986 • 155 citations

The association of HLA-DR alleles and T cell activation with allergic bronchopulmonary aspergillosis.

1997 • 144 citations

Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen.

1992 • 143 citations

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.

1994 • 137 citations

Interleukin 10 (IL-10) regulation of tumour necrosis factor alpha (TNF-alpha) from human alveolar macrophages and peripheral blood monocytes.

1996 • 134 citations

Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice

1997 • 133 citations

A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE.

1992 • 132 citations

Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects.

1997 • 124 citations

Chemokines in allergic inflammation☆, ☆☆, ★

1997 • 122 citations

Eosinophil activation and T lymphocyte infiltration in allergen-induced late phase skin reactions and classical delayed-type hypersensitivity.

1991 • 122 citations

The prevalence of allergic bronchopulmonary aspergillosis in patients with asthma, determined by serologic and radiologic criteria in patients at risk.

1991 • 112 citations

Interleukin‐5 and eosinophils induce airway damage and bronchial hyperreactivity during allergic airway inflammation in BALB/c mice

1997 • 107 citations

Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness.

1997 • 106 citations

Asp f I CD4 + TH2-like T-cell lines in allergic bronchopulmonary aspergillosis

1994 • 105 citations

Particulate Aspergillus fumigatus antigens elicit a TH2 response in BALB/c mice

1994 • 98 citations

The eosinophil: A cytokine-producing cell?

1996 • 93 citations

Regulation of Human Alveolar Macrophage Inflammatory Cytokine Production by Interleukin-10

1996 • 92 citations

Application of enzyme-linked immunosorbent assay (ELISA) in diagnosis of allergic bronchopulmonary aspergillosis.

1982 • 88 citations

A 12-Year Longitudinal Study of Aspergillus Sensitivity in Patients With Cystic Fibrosis

1996 • 79 citations

Differential effects of the T helper cell type 2-derived cytokines IL-4 and IL-5 on ligand binding to IgG and IgA receptors expressed by human eosinophils.

1997 • 72 citations

Variability in parameters of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis

1991 • 70 citations

Identification of allergic bronchopulmonary aspergillosis in cystic fibrosis patients by recombinant Aspergillus fumigatus I/a-specific serology.

1995 • 68 citations

Automated specific IgE assay with recombinant allergens: evaluation of the recombinant Aspergillus fumigatus allergen I in the Pharmacia CAP System

1996 • 65 citations

Expression and functional role of CD23 on T cells

1989 • 64 citations

Aspergillus fumigatus-specific antibodies in allergic bronchopulmonary aspergillosis and aspergilloma: evidence for a polyclonal antibody response

1987 • 60 citations

Diagnosis and Management of Allergic Bronchopulmonary Aspergillosis

1994 • 56 citations

IgE and eosinophil regulation in a murine model of allergic aspergillosis

1994 • 54 citations

CD58 (LFA-3) stimulation provides a signal for human isotype switching and IgE production distinct from CD40.

1994 • 54 citations

Identification of 16, 18, and 45 kd antigens recognized by human IgG and IgE antibodies and murine monoclonal antibodies

1992 • 51 citations

Aspergillus fumigatus peptides differentially express Th1 and Th2 cytokines

1996 • 48 citations

In vitro T cell responses in patients with cystic fibrosis and allergic bronchopulmonary aspergillosis.

1989 • 47 citations

Anti‐interleukin (IL)‐4 and ‐IL‐5 antibodies downregulate IgE and eosinophilia in mice exposed to Aspergillus antigens

1997 • 45 citations

The mechanism of in vitro T helper cell type 1 to T helper cell type 2 switching in highly polarized Leishmania major-specific T cell populations.

1997 • 45 citations

Allergic bronchopulmonary mycosis complicating cystic fibrosis.

1992 • 43 citations

Asp f I CD4 + TH2-like T-cell lines in allergic bronchopulmonary aspergillosis

1994 • 42 citations

Aspergillus antigen-induced eosinophil differentiation in a murine model

1992 • 42 citations

T- and B-cell dysregulation of IgE synthesis in cystic fibrosis patients with allergic bronchopulmonary aspergillosis

1990 • 41 citations

Aspergillus fumigatus antigen induced eosinophilia in mice is abrogated by anti-IL-5 antibody

1993 • 41 citations

Skin Test Reactivity to Recombinant <i>Aspergillus fumigatus</i> Allergen l/a in Patients with Cystic Fibrosis

1996 • 40 citations

New frontiers for IL-5

1997 • 39 citations

Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-γ synthesis in primed CD4 lymphocytes

1996 • 37 citations

Blood eosinophil leukotriene C4 production in asthma of different severities

1995 • 37 citations

Aspergillus ribotoxins react with IgE and IgG antibodies of patients with allergic bronchopulmonary aspergillosis.

1994 • 36 citations

Interleukin-10 decreases tumor necrosis factor alpha and beta in alloreactions induced by human lung dendritic cells and macrophages.

1995 • 35 citations

Immunopathologic responses to Aspergillus antigen in interleukin-4 knockout mice

1997 • 34 citations

Novel Fundamental Approaches to Intervening in IgE-Mediated Allergic Diseases

1994 • 33 citations

Function of CD23 in the response of human B cells to antigen

1997 • 33 citations

Hyperreactivity of mediator-releasing cells from patients with allergic bronchopulmonary aspergillosis as evidenced by basophil histamine release

1983 • 33 citations

Serum immunoglobulins E and G anti-Aspergillus fumigatus antibody in patients with cystic fibrosis who have allergic bronchopulmonary aspergillosis.

1990 • 32 citations

Immunoblot analysis of sera from patients with allergic bronchopulmonary aspergillosis: Correlation with disease activity

1990 • 28 citations

Immune Responses to Aspergillus fumigatus and Pseudomonas aeruginosa Antigens in Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis

1994 • 28 citations

IgE down regulation and cytokine induction by Aspergillus antigens in human allergic bronchopulmonary aspergillosis

1998 • 27 citations

Immunologic and Pathophysiologic Role of Tumor Necrosis Factor

1990 • 27 citations

Experimental Allergic Bronchopulmonary Aspergillosis in the Mouse: Immunological and Histological Features

1994 • 26 citations

Regulation of cytokine release by alveolar macrophages treated with interleukin-4, interleukin-10, or transforming growth factor beta.

1996 • 26 citations

Pairs of surface molecules involved in human IgE regulation: CD23-CD21 and CD40-CD40L.

1996 • 24 citations

Serum IgA antibodies to in various stages of allergic bronchopulmonary aspergillosis

1986 • 23 citations

Specific IgG4 responses during chronic and transient antigen exposure in aspergillosis.

1996 • 23 citations

Allergic bronchopulmonary aspergillosis: serologic update for 1995.

1995 • 22 citations

Antibody isotype responses in Aspergillus-induced diseases.

1990 • 21 citations

Soluble serum interleukin 2 receptors in patients with asthma and allergic bronchopulmonary aspergillosis.

1995 • 20 citations

Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE

1994 • 20 citations

Regulation of Human Monocyte Functions by Interleukin-10

1995 • 19 citations

Allergic Bronchopulmonary Aspergillosis in Patients with Cystic Fibrosis

1990 • 19 citations

Tumor necrosis factor-alpha and interleukin-1 alpha expression in a murine model of allergic bronchopulmonary aspergillosis.

1996 • 19 citations

Development of Bone Marrow Eosinophilia in Mice Induced byAspergillus fumigatusAntigens

1997 • 17 citations

T cells, cytokines, IgE and allergic airways inflammation.

1994 • 16 citations

Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis

1991 • 15 citations

Concanavalin A-nonbinding Aspergillus fumigatus antigen: a major immunogen in allergic bronchopulmonary aspergillosis.

1992 • 11 citations

Antibody Responses to <i>Aspergillus fumigatus</i> Allergens in Patients with Cystic Fibrosis

1995 • 10 citations

IL-10 and Human T Cells

1995 • 6 citations