Apoptosis as a basic mechanism in the ovarian cycle: Follicular atresia and luteal regression

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

INVOLVEMENT OF APOPTOSIS IN OVARIAN FOLLICULAR ATRESIA AND POSTOVULATORY REGRESSION

1991 • 650 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis.

1993 • 536 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Biochemical Identification of Apoptosis (Programmed Cell Death) in Granulosa Cells: Evidence for a Potential Mechanism Underlying Follicular Atresia*

1991 • 510 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

Definition and incidence of apoptosis : an historical perspective

1991 • 458 citations

Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats

1990 • 457 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.

1986 • 380 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

1993 • 348 citations

Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

1992 • 336 citations

The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

1992 • 334 citations

Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis)

1993 • 307 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Deletion of cells by apoptosis during castration-induced involution of the rat prostate

1973 • 285 citations

Apoptosis during luteal regression in cattle.

1993 • 282 citations

Active cell death in hormone-dependent tissues

1992 • 264 citations

Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells.

1992 • 225 citations

Apoptosis in atretic ovarian follicles is associated with selective decreases in messenger ribonucleic acid transcripts for gonadotropin receptors and cytochrome P450 aromatase.

1992 • 219 citations

Activin induces cell death in hepatocytes in vivo and in vitro

1993 • 206 citations

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

1993 • 196 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 195 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Role of apoptosis.

1987 • 193 citations

Atrophy and apoptosis in the cyclical human endometrium

1976 • 192 citations

In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1.

1992 • 190 citations

Adrenocortical cell deletion: The role of ACTH

1973 • 180 citations

Occurrence of cell death (apoptosis) during the involution of liver hyperplasia.

1985 • 174 citations

In Situ Localization of Apoptosis in the Rat Ovary during Follicular Atresia1

1994 • 171 citations

Effect of transforming growth factor beta on cell death of cultured rat hepatocytes.

1991 • 166 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

1992 • 152 citations

The control of apoptosis in mammalian cells

1993 • 139 citations

Retinoic‐acid‐induced limb‐reduction defects: Perturbation of zones of programmed cell death as a pathogenetic mechanism

1989 • 135 citations

DEVELOPMENTAL EXPRESSION OF Ca⁺⁺/Mg⁺⁺-DEPENDENT ENDONUCLEASE ACTIVITY IN RAT GRANULOSA AND LUTEAL CELLS

1989 • 129 citations

Flow cytometry and biochemical analysis of DNA degradation characteristic of two types of cell death

1986 • 129 citations

Programmed cell death and apoptosis

1991 • 115 citations

Expression of the human apolipoprotein AI gene fused to the E. coli gene for β‐galactosidase

1986 • 113 citations

Apoptosis: A Product of Programmed and Unprogrammed Cell Death

1993 • 104 citations

Ultrastructural changes in the theca interna during follicular atresia in sheep

1978 • 101 citations

Biochemical evidence for programmed cell death in rabbit uterine epithelium.

1989 • 95 citations

Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells.

1993 • 89 citations

Changes in Small Blood Vessels During Cyclical Luteal Regression in Sheep

1977 • 82 citations

Prostaglandin-induced apoptosis of ovarian surface epithelial cells

1993 • 71 citations

Ovarian follicular atresia as an apoptotic process: A paradigm for programmed cell death in endocrine tissues

1992 • 51 citations

Apoptosis in the development of the immune system: Growth factors, clonal selection and bcl-2

1992 • 49 citations

Cell deletion by apoptosis during regression of renal hyperplasia.

1989 • 48 citations

Control of cell death (apoptosis) by diethylstilbestrol in an estrogen-dependent kidney tumor

1991 • 48 citations

Cell death (apoptosis) during pancreatic involution after raw soya flour feeding in the rat

1986 • 36 citations

Programmed cell death (apoptosis) in murine blastocysts: extracellular free-radicals, polyamines, and other cytotoxic agents.

1991 • 27 citations