High-resolution analysis of T-cell receptor β-chain repertoires using DNA heteroduplex tracking: generally stable, clonal CD8+ expansions in all healthy young adults

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes

1993 • 788 citations

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

1994 • 788 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 • 562 citations

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

1997 • 527 citations

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

1998 • 434 citations

Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays

1994 • 300 citations

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

1993 • 298 citations

Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS

1997 • 182 citations

Molecular detection and in vivo analysis of the specific T cell response to a protein antigen

1992 • 176 citations

The contrasting structures of mismatched DNA sequences containing looped-out bases (bulges) and multiple mismatches (bubbles)

1989 • 176 citations

Ontogeny of expression of UCHL1 antigen on TcR‐1⁺ (CD4/8) and TcRδ⁺ T cells

1989 • 112 citations

Both CD45RA+ and CD45RA- subpopulations of CD8+ T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression, a phenotype of primed T cells.

1993 • 112 citations

Kinking of DNA and RNA by base bulges.

1995 • 111 citations

Deletions of bases in one strand of duplex DNA, in contrast to single-base mismatches, produce highly kinked molecules: possible relevance to the folding of single-stranded nucleic acids.

1989 • 100 citations

Tracking Changes in HIV-1 Envelope Quasispecies Using DNA Heteroduplex Analysis

1997 • 72 citations

A novel and rapid cloning method for the T-cell receptor variable region sequences

1991 • 65 citations

Predominance of T cells that express CD45R in the CD4+ helper/inducer lymphocyte subset of neonates

1989 • 61 citations

An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations

1996 • 59 citations

CD8⁺ T‐cell clones in old mice

1997 • 57 citations

Progression of Human Immunodeficiency Virus Disease Is Associated with Increasing Disruptions within the CD4⁺T Cell Receptor Repertoire

1998 • 37 citations

Healthy human T-cell receptor β-chain repertoire

1995 • 31 citations

Assessment of T-Cell receptor β-chain diversity by heteroduplex analysis

1996 • 31 citations

The repertoire of T-lymphocytes recovered by bronchoalveolar lavage from healthy nonsmokers

1996 • 26 citations

An alternative approach to the assessment of γδ T-cell clonality in celiac disease intestinal lesions through cDNA heteroduplex analysis of T-cell receptor VJ junctions

1994 • 17 citations

Denaturing and non-denaturing gel electrophoresis as methods for the detection of junctional diversity in rearranged T cell receptor sequences

1995 • 12 citations

Clonal predominance, but preservation of a polyclonal reservoir, in the normal αβ T-cell repertoire

1997 • 11 citations

Direct assessment of junctional diversity in rearranged T cell receptor β chain encoding genes by combined heteroduplex and single strand conformation polymorphism (SSCP) analysis

1996 • 9 citations