Measurement of Anxiety in Transgenic Mice

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

1980 • 1,340 citations

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

1984 • 951 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

Ethopharmacological analysis of rat behavior on the elevated plus-maze

1994 • 823 citations

CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?

1978 • 782 citations

Exploratory behavior models of anxiety in mice

1985 • 730 citations

Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

1994 • 702 citations

Conditioned fear as revealed by magnitude of startle response to an auditory stimulus.

1951 • 649 citations

Thigmotaxis as a test for anxiolytic activity in rats

1988 • 646 citations

Anxiogenic stimuli in the elevated plus-maze

1993 • 626 citations

Fear and fitness: An evolutionary analysis of anxiety disorders

1994 • 610 citations

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

1997 • 553 citations

Sensations Evoked by Stimulation in the Midbrain of Man

1969 • 541 citations

Exploration of mice in a black and white test box: Validation as a model of anxiety

1989 • 535 citations

Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

1981 • 509 citations

5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research

1995 • 497 citations

Animal models for the study of anti-anxiety agents: A review

1985 • 457 citations

Differences in fear motivated behaviors among inbred mouse strains

1993 • 450 citations

Animal models of ??anxiety??: where next?

1997 • 442 citations

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

1997 • 420 citations

The characterization and modelling of antipredator defensive behavior

1990 • 356 citations

Influence of social isolation, gender, strain, and prior novelty on plus-maze behaviour in mice

1993 • 302 citations

Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety

1994 • 286 citations

Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists

1989 • 285 citations

Genetic differences in the rewarding and activating effects of morphine and ethanol

1992 • 271 citations

Relationship between Fos Production and Classical Fear Conditioning: Effects of Novelty, Latent Inhibition, and Unconditioned Stimulus Preexposure

1998 • 250 citations

DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning.

1994 • 238 citations

Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: Elements of face and predictive validity

1995 • 205 citations

DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning.

1994 • 204 citations

Anxiety enhancement in the murine elevated plus maze by immediate prior exposure to social stressors

1993 • 200 citations

Paroxetine efficacy in the treatment of generalized anxiety disorder

1997 • 199 citations

Fear-potentiated startle: Relationship to the level of state/trait anxiety in healthy subjects

1993 • 196 citations

Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety

1998 • 194 citations

Animal models of anxiety based on classical conditioning: The conditioned emotional response (CER) and the fear-potentiated startle effect

1990 • 189 citations

Intrinsic exploration in animals: motives and measurement

1997 • 178 citations

Distress vocalization in rat pups a simple screening method for anxiolytic drugs

1985 • 177 citations

Behaviour of male and female rats with free choice of two environments differing in novelty

1968 • 174 citations

Anxiogenic effects of methyl-β-carboline-3-carboxylate in a light/dark choice situation

1987 • 169 citations

Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test: comparison with haloperidol

1994 • 169 citations

Genetic influences on nicotine responses

1989 • 167 citations

The effects of ethanol and diazepam on reactions to predatory odors

1990 • 150 citations

Obesity, lipids, cardiovascular risk, and androgen excess

1995 • 145 citations

Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour

1985 • 142 citations

A new method for rapid screening of minor tranquillizers in mice

1968 • 124 citations

Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs

1995 • 121 citations

Fear-potentiated startle in two strains of inbred mice.

1997 • 108 citations

Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice

1994 • 108 citations

Further characterization of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines

1983 • 108 citations

Further evidence that the mouse defense test battery is useful for screening anxiolytic and panicolytic drugs: Effects of acute and chronic treatment with alprazolam

1995 • 101 citations

Behavioural and pharmacological characterisation of the canopy stretched attend posture test as a model of anxiety in mice and rats

1997 • 98 citations

The Effects of Intravenous Diazepam and Hyoscine upon Human Memory

1984 • 96 citations

Stretched attend posture, a non-social form of ambivalence, is sensitive to a conflict-reducing drug action

1986 • 86 citations

Latency to enter a mirrored chamber: A novel behavioral assay for anxiolytic agents

1990 • 85 citations

Anxiolytic-like effect of paroxetine in a rat social interaction test

1994 • 85 citations

Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists

1991 • 84 citations

The ambivalent behaviour “stretched approach posture” in the rat as a paradigm to characterize anxiolytic drugs

1995 • 83 citations

Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice

1979 • 76 citations

A comparison of buspirone and chlordiazepoxide in the shock-probe/burying test for anxiolytics

1988 • 72 citations

Behavioural response of wild rodents to the calls of an owl: a comparative study

1998 • 71 citations

Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats

1998 • 70 citations

Clonazepam in the Treatment of Panic Disorder and Agoraphobia

1986 • 70 citations

CONTRIBUTION OF SEX AND GENETICS TO NEUROENDOCRINE ADAPTATION TO STRESS IN MICE

1998 • 68 citations

Predator-elicited plight responses in Swiss-Webster Mice: An experimental model of panic attacks

1996 • 66 citations

Short-term and long-term habituation of the acoustic startle response in chronic decerebrate rats.

1985 • 59 citations

Treatment of panic disorder and agoraphobia with clonazepam.

1986 • 56 citations

The Anxiolytic and Anxiogenic Actions of Ethanol in a Mouse Model

1988 • 52 citations

Short-term and long-term habituation of the acoustic startle response in chronic decerebrate rats.

1985 • 48 citations

Ethanol effects in an anxiety/defense test battery

1990 • 46 citations

Changes in Synaptic Excitability in the Lateral Septum Associated with Contextual and Auditory Fear Conditioning in Mice

1996 • 38 citations

Escape and approach induced by brain stimulation:A parametric analysis

1981 • 38 citations

ACTH, but not corticosterone impairs habituation and reduces exploration

1978 • 38 citations

Effects of quinpirole on the behaviour shown by mice in the light-dark box and during social interactions

1993 • 34 citations

The calls of murine predators activate endogenous analgesia mechanisms in laboratory mice

1991 • 33 citations

Effects of diazepam and picrotoxin on hyponeophagia in rats☆

1982 • 32 citations

Diagnostic dilemmas presented by patients with anxiety and depression

1995 • 29 citations

Effects of acute administration of the 5-HT3 receptor antagonist, BRL 46470A, on the behaviour of mice in a two compartment light-dark box and during social interactions in their home cage and an unfamiliar neutral cage

1992 • 29 citations

β-CCE and chlordiazepoxide reduce exploratory head-dipping and rearing: No mutual antagonism

1982 • 25 citations

Exposure to the calls of predators of mice activates defensive mechanisms and inhibits consummatory behaviour in an inbred mouse strain

1991 • 25 citations

Buspirone increases social investigation in pair-housed male mice; comparison with the effects of chlordiazepoxide

1993 • 21 citations

Effects of acute and subchronic administration of ritanserin on the social behaviour of mice

1993 • 20 citations

Effects of sub-chronic treatment with chlordiazepoxide, buspirone and the 5-HT3 receptor antagonist, BRL 46470, on the social behaviour of mice

1992 • 19 citations

Effects of acute and subchronic administration of propranolol on the social behaviour of mice; An ethopharmacological study

1992 • 18 citations

Fluoxetine in Panic Disorder

1991 • 17 citations

Effects of acute and chronic administration of the antidepressants, imipramine, phenelzine and mianserin, on the social behaviour of mice

1994 • 17 citations

Acute and chronic administration of buspirone fails to yield anxiolytic-like effects in a mouse operant punishment paradigm

1993 • 14 citations

Determinants of Black Politics: Riots and the Growth of Militancy^†

1970 • 12 citations

Effects of SUN 8399, a Potent and Selective 5-HT1A Agonist, on Conflict Behavior and Ambulatory Activity in Mice: Comparison with Those of Buspirone, Tandospirone and Diazepam

1994 • 12 citations

Behavior in chimeric mice combining differently behaving strains

1979 • 11 citations

Dose-response characterization of the antipanic effects of imipramine.

1994 • 6 citations