Drug discrimination models in anxiety and depression

Modification of seizure activity by electrical stimulation: II. Motor seizure

1972 • 6,939 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

The Neuropsychology of Anxiety

2003 • 1,928 citations

Benzodiazepine Receptor: Demonstration in the Central Nervous System

1977 • 1,705 citations

Benzodiazepine receptors in rat brain

1977 • 1,459 citations

The Pharmacological Basis of Therapeutics, 7th ed

1986 • 621 citations

Structural and functional basis for GABAA receptor heterogeneity

1988 • 590 citations

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

1980 • 542 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Serotonin function in anxiety

1987 • 467 citations

Drugs effective in the therapy of the epilepsies

1985 • 461 citations

[³H]8‐Hydroxy‐2‐(Di‐n‐Propylamino)Tetralin Binding to Pre‐ and Postsynaptic 5‐Hydroxytryptamine Sites in Various Regions of the Rat Brain

1985 • 458 citations

The neuropsychology of anxiety

1983 • 438 citations

Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors

1979 • 408 citations

Benzodiazepines: Anxiety-Reducing Activity by Reduction of Serotonin Turnover in the Brain

1972 • 339 citations

The potential anxiolytic activity of GR38032F, a 5‐HT₃‐receptor antagonist

1988 • 332 citations

A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, ?-carbolines, and phenobarbitone

1982 • 312 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)

1988 • 183 citations

Behavioral analogues of anxiety animal models

1983 • 180 citations

Comparison of the degree of discriminability of various drugs using the T-maze drug discrimination paradigm

1982 • 166 citations

Potential antidepressant properties of 8-hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist

1987 • 163 citations

Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors

1987 • 157 citations

Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat

1987 • 156 citations

Evaluation of the ?-carboline ZK 93 426 as a benzodiazepine receptor antagonist

1984 • 154 citations

Imidazopyridines as a tool for the characterization of benzodiazepine receptors: A proposal for a pharmacological classification as omega receptor subtypes

1988 • 146 citations

Pharmacological and clinical effects of buspirone

1985 • 143 citations

The Pharmacology of Benzodiazepines

1991 • 138 citations

Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 137 citations

The effects of p-chlorophenylalanine on experimentally induced conflict in the rat

1969 • 135 citations

Does the excitatory amino acid receptor antagonist 2-APH exhibit anxiolytic activity?

1986 • 123 citations

Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; Relation to some intrinsic and anticonvulsant effects

1976 • 115 citations

Novel non-benzodiazepine anxiolytics

1983 • 109 citations

2-amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam

1986 • 108 citations

ZK 91296, a partial agonist at benzodiazepine receptors

1984 • 107 citations

Potential anxiolytic properties of 8-hydroxy-2-(Di-N-propylamino)tetralin, a selective serotonin1A receptor agonist

1988 • 105 citations

Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors

1986 • 100 citations

Muscle relaxant action of excitatory amino acid antagonists

1985 • 100 citations

Discriminative stimulus properties of ?-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors

1984 • 94 citations

Metrazol tolerance in a “normal” volunteer population

1958 • 91 citations

Discriminative stimulus effects of diazepam in rats: evidence for a maximal effect.

1983 • 91 citations

Effect of anticonvulsants on seizures developing in the course of daily administration of pentetrazol to rats

1977 • 84 citations

Neuropharmacological reassessment of the discriminative stimulus properties ofd-lysergic acid diethylamide (LSD)

1987 • 83 citations

Phencyclidine-like discriminative stimulus properties of MK-801 in rats

1988 • 82 citations

Discriminative stimulus properties of chlordiazepoxide and zolpidem. Agonist and antagonist effects of CGS 9896 and ZK 91296

1987 • 82 citations

Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.

1986 • 81 citations

Discriminative stimulus effects of caffeine and benzphetamine in amphetamine-trained volunteers

1988 • 80 citations

METRAZOL TOLERANCE IN A “NORMAL” VOLUNTEER POPULATION

1970 • 80 citations

Modulation of anxiety by β-carbolines and other benzodiazepine receptor ligands: Relationship of pharmacological to biochemical measures of efficacy

1987 • 80 citations

Ro 15-1788 antagonizes the discriminative stimulus effects of diazepam in rats but not similar effects of pentobarbital

1982 • 79 citations

Evidence that gaba mechanisms mediate the anxiolytic action of benzodiazepines: A study with valproic acid

1980 • 78 citations

Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-d-aspartate receptors?

1988 • 78 citations

The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic

1986 • 76 citations

Buspirone effects in an animal conflict procedure: Comparison with diazepam and phenobarbital

1987 • 76 citations

Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions

1984 • 75 citations

Changing concepts of the biochemical action of the anxioselective drug, buspirone

1984 • 75 citations

Stimulus properties of antidepressants in the rat

1980 • 74 citations

Lorazepam and pentobarbital drug discrimination in baboons: cross-drug generalization and interaction with Ro 15-1788.

1983 • 73 citations

Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics

1987 • 71 citations

A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine

1987 • 71 citations

Drug discrimination studies

1985 • 71 citations

Bidirectional effects of chronic treatment with agonists and inverse agonists at the benzodiazepine receptor

1987 • 69 citations

Discriminative stimulus control by the anxiogenic ß-carboline FG 7142: Generalization to a physiological stressor

1988 • 69 citations

Discriminative stimulus properties of buspirone compared to central nervous system depressants in rats

1983 • 69 citations

Discriminative stimulus effects of atypical anxiolytics in baboons and rats.

1986 • 68 citations

Seizures induced by abrupt discontinuation of alprazolam

1984 • 67 citations

Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine

1987 • 66 citations

Delirium and seizures due to abrupt alprazolam withdrawal: case report.

1984 • 65 citations

Generalization and antagonism studies with convulsant, GABAergic and anticonvulsant drugs in rats trained to discriminate pentylenetetrazol from saline

1980 • 63 citations

The behavioral profile of zolpidem, a novel hypnotic drug of imidazopyridine structure

1987 • 62 citations

Three-choice drug discrimination in opioid-dependent humans: hydromorphone, naloxone and saline.

1987 • 61 citations

Characterization of the Discriminative Stimulus Properties Induced by 5‐HT₁ and 5‐HT₂ Agonists in Rats

1989 • 61 citations

Discriminative stimulus properties of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT)

1986 • 60 citations

IPSAPIRONE, A POTENT AND SELECTIVE 5-HT1A-RECEPTOR LIGAND WITH ANXIOLYTIC AND ANTIDEPRESSANT PROPERTIES

1988 • 60 citations

Differential generalization to pentobarbital in rats trained to discriminate lorazepam, chlordiazepoxide, diazepam, or triazolam

1989 • 58 citations

The discriminative stimulus effects of N-methyl-d-aspartate antagonists in phencyclidine-trained rats

1988 • 56 citations

Discriminative stimulus properties of buspirone in the pigeon.

1987 • 53 citations

The discriminative stimulus produced by pentylenetetrazol: effects of systemic anxiolytics and anxiogenics, aggressive defeat and midazolam or muscimol infused into the amygdala

1988 • 52 citations

β-Carbolines with agonistic and inverse agonistic properties at benzodiazepine receptors of the rat

1984 • 51 citations

Asymmetrical cross‐generalization in drug discrimination with lorazepam and pentobarbital training conditions

1989 • 51 citations

Midazolam cue in rats: Generalization tests with anxiolytic and other drugs

1985 • 50 citations

Antagonism of discriminative stimuli produced by anxiogenic drugs as a novel approach to bioassay anxiolytics

1984 • 49 citations

Second-Generation Antidepressants

1984 • 47 citations

Generalization of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ipsapirone to yohimbine

1988 • 46 citations

Discriminative stimulus properties of cocaine related to an anxiogenic action

1981 • 43 citations

The interoceptive discriminative stimuli induced by the novel putative anxiolytic TVX Q 7821: behavioral evidence for the specific involvement of serotonin 5-HT1A receptors

1987 • 43 citations

Discriminative stimulus effects of a nicotine-midazolam mixture in rats

1987 • 43 citations

Potentiation of the behavioral and convulsant effects of cocaine by chronic administration in the rat

1977 • 43 citations

Effects of chlordiazepoxide training dose on the mixed agonist-antagonist properties of benzodiazepine receptor antagonist Ro 15-1788, in a drug discrimination procedure

1986 • 40 citations

Three-choice drug discrimination in the rat: morphine, cyclazocine and saline.

1981 • 37 citations

Behavioral pharmacological profile of CGS 9895: A novel anxiomodulator with selective benzodiazepine agonist and antagonist properties

1985 • 36 citations

Cross generalization with LSD and yohimbine in the rat

1984 • 33 citations

The non-sedating anxiolytic CGS 9896 produces discriminative stimuli that may be related to an anxioselective effect

1985 • 32 citations

Discriminative Stimulus Properties of Benzodiazepines and Barbiturates

1977 • 32 citations

Further investigation of the stimulus properties of chlordiazepoxide and zolpidem. Agonism and antagonism by two novel benzodiazepines

1987 • 31 citations

Pharmacology of the pyrazolo-type compounds: Agonist, antagonist and inverse agonist actions

1987 • 31 citations

Stimulus properties of benzodiazepines: correlations with binding affinities, therapeutic potency, and structure activity relationships (SAR)

1987 • 30 citations

Neuropharmacological specificity of the diazepam stimulus complex: effects of agonists and antagonists

1983 • 30 citations

Enhanced sensitivity to β-carboline inverse agonists in rats chronically treated with FG 7142

1987 • 30 citations

Diazepam tolerance and withdrawal assessed in an animal model of subjective drug effects

1987 • 29 citations

Discriminative stimulus properties of desipramine

1978 • 27 citations

Morphine, saline and naltrexone discrimination in morphine-treated pigeons.

1987 • 27 citations

Clinical perspectives of β-carbolines from first studies in humans

1987 • 25 citations

Yohimbine and serotonergic agonists: Stimulus properties and receptor binding

1989 • 20 citations

Modulation of the discriminative stimulus produced by pentylenetetrazol by centrally administered drugs

1987 • 19 citations

Effect of the selective N-methyl-D-aspartate receptor agonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid on [3]flunitrazepam binding

1988 • 19 citations

Stability of the stimulus properties of drugs over time

1989 • 19 citations

Discriminative Stimulus Properties of Anxiolytic and Sedative Drugs: Pharmacological Specificity

1988 • 18 citations

Midazolam cue in rats: effects of drugs acting on GABA and 5-hydroxytryptamine systems, anticonvulsants and sedatives

1987 • 18 citations

Kindling with the β-Carboline FG7142 Suggests Separation between Changes in Seizure Threshold and Anxiety-Related Behaviour

1988 • 18 citations

N-methyl-d-aspartate produces discriminative stimuli in rats

1987 • 17 citations

Discriminative stimulus control with imipramine: Transfer to other anti-depressants

1983 • 17 citations

Drug discrimination in pentylenetetrazol‐trained baboons: Generalization to buspirone and β‐carboline‐3‐carboxylic acid ethyl ester but not lorazepam or pentobarbital

1989 • 17 citations

Does the pentylenetetrazole (PTZ) cue reflect PTZ-induced kindling or PTZ-induced anxiogenesis?

1989 • 16 citations

The interaction between zolpidem and β-CMC: a clue to the identification of receptor sites involved in the sedative effect of zolpidem

1988 • 16 citations

Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats

1986 • 15 citations

Beta-carbolines as antagonists of the discriminative stimulus effects of diazepam in rats.

1988 • 15 citations

Discriminative stimulus properties of oxazepam in the pigeon

1987 • 15 citations

Long-term effects of yohimbine on behavioral sensitivity to a stressor

1987 • 14 citations

Discriminative stimulus properties of drugs

1978 • 14 citations

Pharmacological characterization of CGS 17867A as a benzodiazepine receptor agonist devoid of limiting behavioral effects

1987 • 13 citations

Withdrawal from ingested diazepam produces a pentylenetetrazol‐like stimulus in rats

1988 • 13 citations

Rolipram as a discriminative stimuli : Transfer to phosphodiesterase inhibitors.

1987 • 10 citations

Comparison of four-drug discriminations in training compartments with four identical levers versus four different response manipulanda

1988 • 8 citations

Discriminative stimulus properties of CGS 9896: Interactions within the GABA/benzodiazepine receptor complex

1988 • 7 citations

“Second Generation” Antidepressants

1985 • 5 citations

Convulsant actions of the anxiolytic buspirone in combination with antidepressants

1988 • 5 citations

Effects of pyrazolopyridines and a triazolopyridazine on the pentobarbital discriminative stimulus

1987 • 5 citations

Neuropharmacological assessment of the discriminative stimulus properties of the novel anxiolytic ipsapirone

1989 • 5 citations

A comparison of diazepam stimuli in aged and adult rats

1987 • 5 citations

Differential effects of a single dose of imipramine and lopramine in healthy subjects varying in their level of depression

1977 • 5 citations

Discrimination between oral amobarbital and diazepam effects in rats

1989 • 4 citations

Cueing effects of anxiolytic benzodiazepines (DZP and RO 11-3128): stereospecificity and antagonism by the convulsant benzodiazepine Ro 5-3663

1988 • 3 citations