Establishment of a chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94

Protein folding in the cell

1992 • 4,138 citations

KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

1989 • 684 citations

Stress protein systems of mammalian cells

1986 • 564 citations

Mammalian stress response: induction of the glucose-regulated protein family

1992 • 452 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

1977 • 371 citations

The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum

1990 • 310 citations

Expression of heat shock proteins in Alzheimer's disease

1991 • 251 citations

Endoplasmic reticulum contains a common, abundant calcium-binding glycoprotein, endoplasmin

1986 • 236 citations

Human Gene Encoding the 78,000-Dalton Glucose-Regulated Protein and Its Pseudogene: Structure, Conservation, and Regulation

1988 • 236 citations

Effect of gamma rays at the dihydrofolate reductase locus: Deletions and inversions

1986 • 233 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblasts.

1987 • 195 citations

Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells.

1987 • 191 citations

The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion.

1990 • 186 citations

Interconversion of three differentially modified and assembled forms of BiP.

1992 • 180 citations

Intracellular Ca2+ stores in chicken Purkinje neurons: differential distribution of the low affinity-high capacity Ca2+ binding protein, calsequestrin, of Ca2+ ATPase and of the ER lumenal protein, Bip.

1991 • 156 citations

Reduction of Endogenous GRP78 Levels Improves Secretion of a Heterologous Protein in CHO Cells

1988 • 152 citations

Calcium ionophore A23187 induces expression of glucose-regulated genes and their heterologous fusion genes.

1985 • 146 citations

Glucose regulated protein induction and cellular resistance to oxidative stress mediated by porphyrin photosensitization.

1991 • 144 citations

The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells

1991 • 130 citations

Transcriptional regulation of two genes specifically induced by glucose starvation in a hamster mutant fibroblast cell line.

1983 • 128 citations

The accumulation of three specific proteins related to glucose‐regulated proteins in a temperature‐sensitive hamster mutant cell line K12

1981 • 125 citations

Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells.

1988 • 104 citations

Highly conserved glucose-regulated protein in hamster and chicken cells: preliminary characterization of its cDNA clone.

1981 • 102 citations

The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.

1992 • 99 citations

The nucleotide sequence encoding the hamster 78-kDa glucose-regulated protein (GRP78) and its conservation between hamster and rat

1987 • 93 citations

Competitive Inhibition of a Set of Endoplasmic Reticulum Protein Genes (GRP78, GRP94, and ERp72) Retards Cell Growth and Lowers Viability after Ionophore Treatment

1991 • 75 citations

Brefeldin A as a regulator of grp78 gene expression in mammalian cells.

1992 • 71 citations

Common sets of nuclear factors binding to the conserved promoter sequence motif of two coordinately regulated ER protein genes,GRP78andGRP94

1991 • 69 citations

Accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium. A putative role for GRP78

1990 • 59 citations

Enhanced transcription of the 78,000-dalton glucose-regulated protein (GRP78) gene and association of GRP78 with immunoglobulin light chains in a nonsecreting B-cell myeloma line (NS-1).

1989 • 54 citations

Competitive inhibition of a set of endoplasmic reticulum protein genes (GRP78, GRP94, and ERp72) retards cell growth and lowers viability after ionophore treatment.

1991 • 53 citations

Effects of stress on lysability of tumor targets by cytotoxic T cells and tumor necrosis factor.

1990 • 43 citations

The organization of the rat GRP78 gene and A23187-induced expression of fusion gene products targeted intracellularly

1988 • 32 citations