Activation-independent Parathyroid Hormone Receptor Internalization Is Regulated by NHERF1 (EBP50)

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

ERM proteins and merlin: integrators at the cell cortex

2002 • 1,301 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex

1999 • 530 citations

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

1993 • 426 citations

A novel mechanism for skeletal resistance in uremia

2000 • 416 citations

ERM-Merlin and EBP50 Protein Families in Plasma Membrane Organization and Function

2000 • 375 citations

Na+/H+ exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

2002 • 310 citations

A Novel Immunoradiometric Assay Detects Full-Length Human PTH but not Amino-Terminally Truncated Fragments: Implications for PTH Measurements in Renal Failure

1999 • 284 citations

Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

2001 • 276 citations

Efficacy at g-protein-coupled receptors

2002 • 257 citations

Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms

1998 • 208 citations

Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor.

1997 • 198 citations

The Carboxyl-terminal Region of EBP50 Binds to a Site in the Amino-terminal Domain of Ezrin That Is Masked in the Dormant Molecule

1998 • 194 citations

A Homozygous Inactivating Mutation in the Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Causing Blomstrand Chondrodysplasia

1998 • 166 citations

Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo

1999 • 166 citations

Structure-function relationship of parathyroid hormone: activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells.

1992 • 153 citations

Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation

2001 • 152 citations

The B1 Subunit of the H+ATPase Is a PDZ Domain-binding Protein

2000 • 150 citations

Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways

2003 • 150 citations

The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure

1994 • 144 citations

Endocytosis of Ligand-Human Parathyroid Hormone Receptor 1 Complexes Is Protein Kinase C-dependent and Involves β-Arrestin2

1999 • 144 citations

Immunoheterogeneity of Parathyroid Hormone in Venous Effluent Serum from Hyperfunctioning Parathyroid Glands

1977 • 144 citations

Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK

2001 • 137 citations

Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction.

1994 • 136 citations

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases

1999 • 134 citations

A Parathyroid Hormone Inhibitor in Vivo: Design and Biological Evaluation of a Hormone Analog

1983 • 119 citations

Ezrin-Radixin-Moesin-binding Phosphoprotein-50/Na+/H+ Exchanger Regulatory Factor (EBP50/NHERF) Blocks U50,488H-induced Down-regulation of the Human κ Opioid Receptor by Enhancing Its Recycling Rate

2002 • 116 citations

Evidence for Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) Self-association through PDZ-PDZ Interactions

2000 • 114 citations

Oligomerization of NHERF-1 and NHERF-2 PDZ Domains: Differential Regulation by Association with Receptor Carboxyl-Termini and by Phosphorylation

2001 • 108 citations

Differential Conformational Requirements for Activation of G Proteins and the Regulatory Proteins Arrestin and G Protein-coupled Receptor Kinase in the G Protein-coupled Receptor for Parathyroid Hormone (PTH)/PTH-related Protein

2001 • 107 citations

A Role for N-Cadherin in the Development of the Differentiated Osteoblastic Phenotype

2000 • 105 citations

Identification of Phosphorylation Sites in the G Protein-Coupled Receptor for Parathyroid Hormone. Receptor Phosphorylation Is Not Required for Agonist-Induced Internalization

1998 • 98 citations

Internalization Determinants of the Parathyroid Hormone Receptor Differentially Regulate β-Arrestin/Receptor Association

2002 • 97 citations

Selective Ligand-induced Stabilization of Active and Desensitized Parathyroid Hormone Type 1 Receptor Conformations

2002 • 95 citations

The Adenosine 2b Receptor Is Recruited to the Plasma Membrane and Associates with E3KARP and Ezrin upon Agonist Stimulation

2002 • 93 citations

Origin of parathyroid hormone (PTH) fragments detected by intact-PTH assays

2002 • 76 citations

Distinct cell type-specific expression of scaffolding proteins EBP50 and E3KARP: EBP50 is generally expressed with ezrin in specific epithelia, whereas E3KARP is not

2002 • 74 citations

Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.

1996 • 74 citations

Phosphorylation of the Receptor for PTH and PTHrP Is Required for Internalization and Regulates Receptor Signaling

2002 • 70 citations

Cell-Specific Signaling and Structure-Activity Relations of Parathyroid Hormone Analogs in Mouse Kidney Cells**This work was supported by NIH Grant R01-DK-54171 and an American Society of Nephrology Career Enhancement Award.

1999 • 69 citations

Separation of the structural requirements for agonist-promoted activation and sequestration of the beta-adrenergic receptor.

1990 • 64 citations

PTH-PTHrP Receptor mRNA Is Downregulated in Chronic Renal Failure

1994 • 59 citations

Regulation of GTP-binding Protein αq(Gαq) Signaling by the Ezrin-Radixin-Moesin-binding Phosphoprotein-50 (EBP50)

2002 • 55 citations

A NEW HIGHLY POTENT PARATHYROID HORMONE ANTAGONIST: [D-TRP^l2,TYR³⁴]bPTH-(7–34)NH₂

1988 • 54 citations

Cellular Distribution of Constitutively Active Mutant Parathyroid Hormone (PTH)/PTH-Related Protein Receptors and Regulation of Cyclic Adenosine 3′,5′-Monophosphate Signaling by β-Arrestin2

2001 • 54 citations

The Endothelin Subtype A Receptor Undergoes Agonist- and Antagonist-Mediated Internalization in the Absence of Signaling¹

1998 • 49 citations

Parathyroid Hormone Receptor Recycling: Role of Receptor Dephosphorylation and β-Arrestin

2002 • 48 citations

Biosynthesis of Parathyroid Hormone

1977 • 47 citations

Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs)11Abbreviations: PTH, parathyroid hormone; PTHrP, PTH-related protein; cAMP, cyclic AMP; Tris, tris(hydroxymethyl)-aminomethane; Kd, dissociation constant; Bmax, maximal number of specific binding sites; PLC, phospholipase C; G-protein, guanine nucleotide regulatory protein; DMEM, Dulbecco’s modified Eagle’s medium; RT-PCR, reverse transcription-polymerase chain reaction; IBMX, …

2001 • 43 citations

Parathyroid hormone 1–34, but not 3–34 or 7–34, transiently translocates protein kinase C in cultured renal (OK) cells

1989 • 41 citations

Essential Role for NHERF in cAMP-mediated Inhibition of the Na+-HCO3-Co-transporter in BSC-1 Cells

2001 • 34 citations

Inhibition of the in vivo parathyroid hormone-mediated calcemic response in rats by a synthetic hormone antagonist.

1986 • 31 citations

Cysteine proteinases in rat parathyroid cells with special reference to their correlation with parathyroid hormone (PTH) in storage granules.

1993 • 30 citations

PTH stimulates PLCβ and PLCγ isoenzymes in rat enterocytes: influence of ageing

2001 • 23 citations

Role of Signal Transduction in Internalization of the G Protein-Coupled Receptor for Parathyroid Hormone (PTH) and PTH-Related Protein*

1999 • 20 citations