The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I− targeting to the membrane

BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas

2003 • 1,042 citations

The Sodium/Iodide Symporter (NIS): Characterization, Regulation, and Medical Significance

2003 • 828 citations

Guilty as charged

2004 • 783 citations

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

2003 • 671 citations

Clinical Implication of Hot SpotBRAFMutation, V599E, in Papillary Thyroid Cancers

2003 • 539 citations

High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.

2003 • 424 citations

Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation

2005 • 415 citations

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

2016 • 304 citations

Immunohistochemical Profile of the Sodium/Iodide Symporter in Thyroid, Breast, and Other Carcinomas Using High Density Tissue Microarrays and Conventional Sections

2003 • 293 citations

BRAF^V599EMutation Is the Leading Genetic Event in Adult Sporadic Papillary Thyroid Carcinomas

2004 • 268 citations

Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells

2005 • 224 citations

Type and Prevalence of BRAF Mutations Are Closely Associated With Papillary Thyroid Carcinoma Histotype and Patients' Age But Not With Tumour Aggressiveness

2006 • 217 citations

Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations

2005 • 212 citations

BRAF mutations in an Italian cohort of thyroid cancers

2004 • 180 citations

RAPID COMMUNICATION: Predominant Intracellular Overexpression of the Na+/I− Symporter (NIS) in a Large Sampling of Thyroid Cancer Cases

2001 • 178 citations

Advances in Na+/I− symporter (NIS) research in the thyroid and beyond

2003 • 177 citations

RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase

2003 • 174 citations

Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas.

1998 • 148 citations

BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas

2004 • 129 citations

The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.

1993 • 128 citations

Prevalence of mutations of ras and p53 in benign and malignant thyroid tumors from children exposed to radiation after the Chernobyl nuclear accident.

1996 • 124 citations

Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene.

1993 • 116 citations

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.

1996 • 103 citations

Immunohistochemical Analysis of Sodium Iodide Symporter Expression in Metastatic Differentiated Thyroid Cancer: Correlation with Radioiodine Uptake

2001 • 100 citations

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

2005 • 100 citations

PI3K Is Involved in the IGF-I Inhibition of TSH-Induced Sodium/Iodide Symporter Gene Expression

2002 • 85 citations

Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Follow-Up of Papillary or Follicular Thyroid Cancer

2001 • 83 citations

Failure of Membrane Targeting Causes the Functional Defect of Two Mutant Sodium Iodide Symporters¹

2000 • 65 citations

Low expression of sodium iodide symporter identifies aggressive thyroid tumors

2003 • 63 citations

Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity.

1993 • 59 citations

Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene

1993 • 50 citations

Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity

1993 • 39 citations

Immunohistochemical Analysis of Sodium Iodide Symporter Expression in Metastatic Differentiated Thyroid Cancer: Correlation with Radioiodine Uptake

2001 • 37 citations

Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Follow-Up of Papillary or Follicular Thyroid Cancer

2001 • 37 citations

Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients’ age but not with tumour aggressiveness

2005 • 29 citations

DARPP-32 (Dopamine and 3′,5′-Cyclic Adenosine Monophosphate-Regulated Neuronal Phosphoprotein) Is Essential for the Maintenance of Thyroid Differentiation

2005 • 17 citations

PI3K Is Involved in the IGF-I Inhibition of TSH-Induced Sodium/Iodide Symporter Gene Expression

2002 • 15 citations

Expression of the sodium iodide symporter in differentiated thyroid cancer: clinical evidence.

2005 • 6 citations

Cited By (0)

Loading...