Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

2003 • 1,490 citations

Processing of gene expression data generated by quantitative real-time RT-PCR.

2002 • 1,402 citations

The RAF proteins take centre stage

2004 • 1,158 citations

BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas

2003 • 1,042 citations

BRAF Mutation in Papillary Thyroid Carcinoma

2003 • 915 citations

Guilty as charged

2004 • 783 citations

The Raf/MEK/ERK pathway: new concepts of activation

2001 • 716 citations

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

2003 • 671 citations

Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.

1997 • 638 citations

Anaplastic thyroid carcinoma

2005 • 636 citations

Clinical Implication of Hot SpotBRAFMutation, V599E, in Papillary Thyroid Cancers

2003 • 539 citations

The ins and outs of Raf kinases

1994 • 537 citations

Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the United States during 1996

2000 • 509 citations

Anaplastic Thyroid Carcinoma: A Study of 70 Cases

1985 • 469 citations

Raf proteins and cancer: B-Raf is identified as a mutational target

2003 • 454 citations

Regulation of Thyroid Cell Proliferation by TSH and Other Factors: A Critical Evaluation of in Vitro Models

2001 • 441 citations

High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.

2003 • 424 citations

Molecular Profile and Clinical-Pathologic Features of the Follicular Variant of Papillary Thyroid Carcinoma: An Unusually High Prevalence of ras Mutations

2003 • 373 citations

BRAF mutations are associated with some histological types of papillary thyroid carcinoma

2004 • 366 citations

Molecular Profile and Clinical-Pathologic Features of the Follicular Variant of Papillary Thyroid Carcinoma

2003 • 338 citations

Levothyroxine Therapy in Patients with Thyroid Disease

1993 • 330 citations

BRAF mutations in papillary carcinomas of the thyroid

2003 • 301 citations

Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.

1996 • 292 citations

Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer

2004 • 266 citations

The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.

1998 • 250 citations

One- and Two-Step Transformations of Rat Thyroid Epithelial Cells by Retroviral Oncogenes

1987 • 244 citations

Mutations of the BRAF Gene in Papillary Thyroid Carcinoma in a Korean Population

2004 • 229 citations

Mice with a Mutation in the Thyroid Hormone Receptor β Gene Spontaneously Develop Thyroid Carcinoma: A Mouse Model of Thyroid Carcinogenesis

2002 • 192 citations

Long-Term Outcome of Patients With Differentiated Thyroid Carcinoma: Effect of Therapy

2000 • 190 citations

BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment

2004 • 176 citations

RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase

2003 • 174 citations

Molecular Mechanisms of RET Activation in Human Cancer

2002 • 171 citations

How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy

2004 • 157 citations

Improved Radioimmunoassay for Measurement of Mouse Thyrotropin in Serum: Strain Differences in Thyrotropin Concentration and Thyrotroph Sensitivity to Thyroid Hormone

1999 • 154 citations

Loss of p53 Promotes Anaplasia and Local Invasion in ret/PTC1-Induced Thyroid Carcinomas

2000 • 104 citations

Multiple Ras Downstream Pathways Mediate Functional Repression of the Homeobox Gene Product TTF-1

2000 • 64 citations

A Dominant Negative CREB (cAMP Response Element-Binding Protein) Isoform Inhibits Thyrocyte Growth, Thyroid-Specific Gene Expression, Differentiation, and Function

2000 • 62 citations

Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice

1999 • 61 citations

Serum Tests for Measurement of Thyroid Function

1971 • 61 citations

Hypothyroidism in Thyroid Transcription Factor 1 Haploinsufficiency Is Caused by Reduced Expression of the Thyroid-Stimulating Hormone Receptor

2003 • 60 citations

Thyroid Carcinomas in RET/PTC Transgenic Mice

1998 • 54 citations

Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes

2003 • 50 citations

Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53−/− mice

2001 • 44 citations

Gender, age, goitre type and serum TSH level predict thyroid neoplasia in 1500 patients with thyroid enlargement investigated by FNAC

2004 • 1 citations