Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

1977 • 1,579 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

AETIOLOGY OF PARKINSON'S DISEASE

1983 • 463 citations

Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP

1984 • 199 citations

Mitochondrial Monoamine Oxidase

1968 • 173 citations

Purification and properties of mitochondrial monoamine oxidase type A from human placenta.

1985 • 149 citations

V. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 148 citations

MPTP: A neurotoxin producing a parkinsonian syndrome

1987 • 146 citations

Monoamine oxidase from beef liver mitochondria: Simplified isolation procedure, properties, and determination of its cysteinyl flavin content

1979 • 139 citations

Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1985 • 118 citations

Neurology: Predicting Parkinson's disease

1985 • 93 citations

Mechanism of inactivation of monoamine oxidase by trans-2-phenylcyclopropylamine and the structure of the enzyme-inactivator adduct.

1983 • 92 citations

Suicide inactivation of monoamine oxidase by trans-phenylcyclopropylamine.

1980 • 72 citations

Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 69 citations

Studies on the 1-methyl-4-phenyl-2,3-dihydropyridinium species 2,3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nitrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 68 citations

BIOCHEMICAL PHARMACOLOGY AND TOXICOLOGY

1980 • 64 citations

Parkinson's Disease: An Environmental Cause?

1985 • 62 citations

Iron content and spectral properties of highly purified bovine liver monoamine oxidase

1981 • 52 citations

Spectra of chloroperoxidase Compounds II and III

1985 • 45 citations

Monkey Model of Parkinson's Disease

1983 • 43 citations

Inhibition of types A and B monoamine oxidase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1985 • 41 citations

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