Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

1994 • 769 citations

Transgenic Gαq overexpression induces cardiac contractile failure in mice

1997 • 636 citations

Rho GTPases

1998 • 534 citations

Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

1995 • 530 citations

Enhanced Gαq signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure

1998 • 528 citations

Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.

1990 • 486 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

Myosin heavy chain gene expression in human heart failure.

1997 • 402 citations

Transthoracic Echocardiography in Models of Cardiac Disease in the Mouse

1996 • 372 citations

Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice

1995 • 314 citations

Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor

1993 • 304 citations

Transient cardiac expression of constitutively active Gα_qleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

1998 • 262 citations

The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy

1997 • 231 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

Angiotensin II Activates RhoA in Cardiac Myocytes

1998 • 224 citations

Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

1996 • 220 citations

Overexpression of angiotensin AT ₁ receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

1997 • 214 citations

Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes

1997 • 206 citations

Decompensation of Pressure-Overload Hypertrophy in Gαq-Overexpressing Mice

1998 • 204 citations

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

1996 • 203 citations

The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes

1998 • 194 citations

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

1994 • 189 citations

Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function

1998 • 172 citations

Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice.

1993 • 155 citations

MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

1997 • 152 citations

Hypertrophy, Pathology, and Molecular Markers of Cardiac Pathogenesis

1998 • 116 citations

The Small GTP-Binding Protein RhoA Regulates a Delayed Rectifier Potassium Channel

1998 • 111 citations

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.

1997 • 100 citations

Cloning and expression of a rat cardiac delayed rectifier potassium channel.

1991 • 71 citations

Ras and Rho are Required for Gαq-Induced Hypertrophic Gene Expression in Neonatal Rat Cardiac Myocytes

1998 • 63 citations

Ras Activity Is Required for Phenylephrine-Induced Activation of Mitogen-Activated Protein Kinase in Cardiac Muscle Cells

1994 • 52 citations

Studies on the function of Rho A protein in cardiac myofibrillogenesis

1997 • 43 citations