Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.

1976 • 398 citations

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.

1975 • 381 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.

1976 • 314 citations

Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol.

1975 • 248 citations

Evidence for Interdependent Action of Glucagon and Nucleotides on the Hepatic Adenylate Cyclase System

1974 • 244 citations

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.

1975 • 235 citations

β-Adrenergic Receptor: Stereospecific Interaction of Iodinated β-Blocking Agent with High Affinity Site

1974 • 229 citations

A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes.

1975 • 221 citations

Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells.

1976 • 219 citations

Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes.

1976 • 203 citations

Adenylate Cyclase in Islets of Langerhans

1973 • 178 citations

Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythrocytes.

1977 • 177 citations

The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activiation

1975 • 171 citations

Stimulation and Desensitization of Macrophage Adenylate Cyclase by Prostaglandins and Catecholamines

1974 • 166 citations

Requirement for Guanosine Triphosphate in the Prostaglandin Activation of Adenylate Cyclase of Platelet Membranes

1972 • 166 citations

Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding.

1976 • 164 citations

Oxytocin-sensitive Adenylate Cyclase in Frog Bladder Epithelial Cells

1972 • 164 citations

The Binding Characteristics and Number of β-Adrenergic Receptors on the Turkey Erythrocyte

1974 • 151 citations

Glucagon Receptors in β-Cells

1972 • 145 citations

Catecholamine binding to the beta-adrenergic receptor.

1977 • 134 citations

The Effects of Nucleotides on the Expression of β-Adrenergic Adenylate Cyclase Activity in Membranes from Turkey Erythrocytes

1974 • 118 citations

Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.

1976 • 116 citations

The Glucagon-sensitive Adenylate Cyclase System in Plasma Membranes of Rat Liver

1972 • 112 citations

Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines.

1976 • 101 citations

Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.

1976 • 100 citations

Conformational Changes in Ribosomes during Protein Synthesis

1971 • 68 citations

Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes.

1977 • 61 citations

Desensitization of Beta Adrenergic Receptors in Human Fibroblasts in Tissue Culture

1975 • 46 citations

Guanosine triphosphate binding sites in solubilized myocardium. Relation to adenylate cyclase activity.

1975 • 43 citations

The regulatory control of β-receptor dependent adenylate cyclase

1976 • 30 citations

Catecholamine stimulated myocardial adenylate cyclase: Effects of nucleotides

1975 • 16 citations

Irreversible activation of adenylate cyclase of toad erythrocyte plasma membrane by 5′-guanylylimidodiphosphate

1976 • 14 citations