Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

Relationship between the beta-adrenergic receptor and adenylate cyclase.

1977 • 497 citations

GTP-binding proteins in membranes and the control of adenylate cyclase activity.

1977 • 456 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.

1976 • 314 citations

Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.

1978 • 281 citations

Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.

1977 • 228 citations

Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.

1977 • 216 citations

Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.

1977 • 156 citations

Agonist-induced increase in apparent β-adrenergic receptor size

1978 • 138 citations

Catecholamine binding to the beta-adrenergic receptor.

1977 • 134 citations

Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding.

1979 • 122 citations

Solubilization and separation of the glucagon receptor and adenylate cyclase in guanine nucleotide-sensitive states.

1977 • 113 citations

Identification and persistence of beta adrenergic receptors during maturation of the rat reticulocyte.

1977 • 62 citations

Independent variation of β-adrenergic receptor binding and catecholamine-stimulated adenylate cyclase activity in rat erythrocytes

1976 • 57 citations

ADP-ribosylation of membrane proteins and activation of adenylate cyclase by cholera toxin in fat cell ghosts from euthyroid and hypothyroid rats

1979 • 48 citations

The role of guanyl nucleotides in the expression on of catecholamine-responsive adenylate cyclase during maturation of the rat reticulocyte.

1977 • 38 citations

The ?-adrenergic receptor-adenyl-cyclase system of rat reticulocytes

1975 • 37 citations

Dissociation of beta-adrenergic receptors from hormone responsiveness during maturation of the rat reticulocyte

1978 • 24 citations

Beta-adrenergic receptors and adenylate cyclase activity in rat reticulocytes and mature erythrocytes

1979 • 22 citations

Correlation between isoprenaline-stimulated synthesis of cyclic AMP and occurrence of β-adrenoreceptors in immature erythrocytes from rats

1978 • 21 citations

Differential effects of GTP on the coupling of β-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes application of new methods for the analysis of receptor-effector coupling

1979 • 12 citations