Population distribution and effects on drug metabolism of a genetic variant in the 5′ promotor region of CYP3A4

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors

1997 • 1,161 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM

1997 • 540 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

1992 • 536 citations

RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1999 • 478 citations

Noninvasive tests of CYP3A enzymes

1994 • 414 citations

CYP3A gene expression in human gut epithelium

1994 • 367 citations

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

1994 • 350 citations

Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1998 • 348 citations

Association of CYP 3 A 4 genotype with treatment-related leukemia

1998 • 315 citations

Cytochrome P4503A (CYP3A) metabolism: Prediction ofIn Vivo activity in humans

1996 • 308 citations

Gene structure of CYP3A4, an adult‐specific form of cytochrome P450 in human livers, and its transcriptional control

1993 • 208 citations

Variability in nifedipine pharmacokinetics and dynamics: A new oxidation polymorphism in man

1984 • 182 citations

Ethnic Differences in Drug Disposition and Responsiveness

1991 • 154 citations

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4???-hydroxylation activities in livers of Japanese and Caucasian populations

1997 • 134 citations

Intraindividual variability in the relative systemic availability of cyclosporin after oral dosing

1988 • 124 citations

Prostate Cancer Incidence and Mortality Rates among White and Black Men

1997 • 115 citations

Molecular basis of polymorphic drug metabolism

1995 • 114 citations

Race, Prostate Cancer Survival, and Membership in a Large Health Maintenance Organization

1998 • 113 citations

Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.

1989 • 67 citations

Pharmacokinetics of cyclosporine: inter- and intra-individual variations and metabolic pathways.

1990 • 61 citations

Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats.

1987 • 61 citations

Ethnic differences in the pharmacokinetics of oral nifedipine.

1991 • 60 citations

Sequences of intestinal and hepatic cytochrome P450 3A4 cDNAs are identical.

1998 • 56 citations

The influences of dose and ethnic origins on the pharmacokinetics of nifedipine

1993 • 53 citations

Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.

1997 • 49 citations

Triazolam pharmacokinetics and pharmacodynamics in Caucasians and Southern Asians: ethnicity and CYP3A activity

1996 • 43 citations

Effect of Multiple Doses of Rifampin on the [¹⁴C N‐methyl] Erythromycin Breath Test in Healthy Male Volunteers

1998 • 33 citations

PREDICTION OF INTERPATIENT AND INTRAPATIENT VARIATION IN OG 37–325 DOSING REQUIREMENTS BY THE ERYTHROMYCIN BREATH TEST

1994 • 19 citations

PREDICTION OF INTERPATIENT AND INTRAPATIENT VARIATION IN OG 37–325 DOSING REQUIREMENTS BY THE ERYTHROMYCIN BREATH TEST

1994 • 16 citations

Racial differences in drug metabolism: an explanation. for higher breast cancer mortality in blacks?

1998 • 14 citations