Nitrone Inhibition of Age‐Associated Oxidative Damage

Superoxide Dismutase

1969 • 12,578 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Spin trapping

1971 • 829 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Free Radicals in Biological Materials

1954 • 713 citations

Hydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation

1986 • 660 citations

Production of superoxide anions by a CNS macrophage, the microglia

1987 • 619 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

1971 • 544 citations

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

1998 • 507 citations

Oxygen free radical involvement in ischemia and reperfusion injury to brain

1988 • 429 citations

p38 Kinase Is Activated in the Alzheimer's Disease Brain

1999 • 365 citations

Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Inducible Nitric-oxide Synthase Expression in Mouse Astrocytes

1997 • 300 citations

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development

1999 • 248 citations

Methylene blue plus light mediates 8-hydroxyguanine formation in DNA

1989 • 229 citations

Delayed treatment with the spin trap α‐phenyl‐N‐tert‐butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats

1994 • 196 citations

Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCE) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats

1986 • 164 citations

Hydroxyl free radical mediated formation of 8-hydroxyguanine in isolated DNA

1988 • 161 citations

Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane

1978 • 155 citations

Activation of p38^MAPK in Microglia After Ischemia

1998 • 152 citations

Interaction of α‐Phenyl‐N‐tert‐Butyl Nitrone and Alternative Electron Acceptors with Complex I Indicates a Substrate Reduction Site Upstream from the Rotenone Binding Site

1998 • 118 citations

AN IDENTIFICATION OF THE RADICAL GIVING RISE TO THE LIGHT‐INDUCED ELECTRON SPIN RESONANCE SIGNAL IN PHOTOSYNTHETIC BACTERIA

1969 • 115 citations

Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat

1997 • 111 citations

Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture

1999 • 111 citations

The Spin-Trap N-tert-α-Phenylbutylnitrone Prolongs the Life Span of the Senescence-Accelerated Mouse

1995 • 110 citations

Quantitation of Protein-Bound 3-Nitrotyrosine and 3,4-Dihydroxyphenylalanine by High-Performance Liquid Chromatography with Electrochemical Array Detection

1997 • 88 citations

Spin Trapping Agent, Phenyl N-tertbutyl Nitrone (PBN) Inhibits Induction of Nitric Oxide Synthase in Endotoxin-Induced Shock in Mice

1995 • 87 citations

Chapter 13 Nitrone-Based Free Radical Traps as Neuroprotective Agents in Cerebral Ischaemia and Other Pathologies

1996 • 85 citations

The Free Radical Trapping Agent N-Tert.-Butyl-α-Phenylnitrone (PBN) Attenuates Cerebral Ischaemic Injury in Gerbils

1991 • 76 citations

Phenyl-T-Butyl-Nitrone is Active Against Traumatic Shock in Rats

1986 • 69 citations

A Spin Trap, N-tert-Butyl-α-phenylnitrone Extends the Life Span of Mice

1998 • 64 citations

Protective Action of Nitrone-Based Free Radical Traps against Oxidative Damage to the Central Nervous System

1996 • 55 citations

Inhibition by phenyl N-tert-butyl nitrone of early phase carcinogenesis in the livers of rats fed a choline-deficient, L-amino acid-defined diet.

1998 • 46 citations

In VivoTrapping of Nitric Oxide in the Brain of Neonatal Rats Treated with the HIV-1 Envelope Protein gp 120: Protective Effects of α-Phenyl-tert-butylnitrone

1996 • 26 citations

Fundamentals of oxidation and respiration.

1946 • 19 citations

Anti-Shock Action of Phenyl-t-Butyl-Nitrone, a Spin Trapper

2015 • 17 citations

Nitrone radical traps protect in experimental neurodegenerative diseases

1996 • 11 citations

Gene Expression and Functional Changes After Acute Ischemia: Age-Related Differences in Outcome and Mechanisms

1994 • 8 citations