Back to search

Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin.

Data up to Jan 2025

Published2003
Citations299
References75

Total Citations Per Year

Abstract

References (75)

Helicobacter pyloriInfection and the Development of Gastric Cancer

2001 • 4,276 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

2000 • 2,355 citations

Helicobacter pylori and gastrointestinal tract adenocarcinomas

2002 • 1,775 citations

Helicobacter pyloriInfection and Gastric Carcinoma among Japanese Americans in Hawaii

1991 • 1,769 citations

Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

1995 • 1,551 citations

Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

1991 • 1,399 citations

Helicobacter pylori infection induces gastric cancer in Mongolian gerbils

1998 • 997 citations

Purification and characterization of the vacuolating toxin from Helicobacter pylori.

1992 • 700 citations

Cytotoxic activity in broth-culture filtrates of Campylobacter pylori

1988 • 681 citations

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori

1997 • 649 citations

Helicobacter pylori and Interleukin 1 Genotyping: An Opportunity to Identify High-Risk Individuals for Gastric Carcinoma

2002 • 629 citations

Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

1994 • 594 citations

Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin

1999 • 591 citations

Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection

1994 • 526 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

1994 • 490 citations

Geographic distribution of vacA allelic types of Helicobacter pylori

1999 • 455 citations

Induction of gastric epithelial apoptosis by Helicobacter pylori.

1996 • 425 citations

Helicobacter Pylori: Physiology and Genetics

2001 • 419 citations

Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells

1997 • 413 citations

Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils.

1998 • 412 citations

Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells.

1998 • 363 citations

The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release

2000 • 354 citations

Purification and characterization of urease from Helicobacter pylori.

1990 • 351 citations

Helicobacter pylori-Induced Mucosal Inflammation Is Th1 Mediated and Exacerbated in IL-4, But Not IFN-γ, Gene-Deficient Mice

2000 • 343 citations

Helicobacter pylori cagA+ Strains and Dissociation of Gastric Epithelial Cell Proliferation From Apoptosis

1997 • 339 citations

Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses

2001 • 326 citations

Regulation of gastric epithelial cell growth by Helicobacter pylori: Offdence for a major role of apoptosis

1997 • 320 citations

Genetic analysis of the Helicobacter pylori vacuoiating cytotoxin: structural similarities with the IgA protease type of exported protein

1994 • 313 citations

A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach

1994 • 294 citations

Expanding Allelic Diversity of Helicobacter pylori vacA

1998 • 280 citations

Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection.

1997 • 276 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis.

1998 • 253 citations

Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection

1998 • 238 citations

Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments.

1994 • 232 citations

Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori

1994 • 225 citations

Low pH Activates the Vacuolating Toxin of Helicobacter pylori, Which Becomes Acid and Pepsin Resistant

1995 • 217 citations

The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH

1999 • 212 citations

Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle.

1999 • 212 citations

Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease

1995 • 204 citations

Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly

1997 • 199 citations

Vacuoles Induced by Helicobacter pylori Toxin Contain Both Late Endosomal and Lysosomal Markers

1997 • 189 citations

H. pylori activates NF-κB through a signaling pathway involving IκB kinases, NF-κB—inducing kinase, TRAF2, and TRAF6 in gastric cancer cells

2000 • 189 citations

Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils

2000 • 186 citations

α-Toxin is a mediator of Staphylococcus aureus–induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling

2001 • 183 citations

Vacuolating Cytotoxin of Helicobacter pylori Induces Apoptosis in the Human Gastric Epithelial Cell Line AGS

2001 • 174 citations

The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany

2000 • 158 citations

Helicobacter pylori Urease Binds to Class II MHC on Gastric Epithelial Cells and Induces Their Apoptosis

2000 • 156 citations

Helicobacter pyloriInduces Gastric Epithelial Cell Apoptosis in Association with Increased Fas Receptor Expression

1999 • 151 citations

A Dominant Negative Mutant of Helicobacter pyloriVacuolating Toxin (VacA) Inhibits VacA-induced Cell Vacuolation

1999 • 131 citations

A 12-Amino-Acid Segment, Present in Type s2 but Not Type s1 Helicobacter pylori VacA Proteins, Abolishes Cytotoxin Activity and Alters Membrane Channel Formation

2001 • 123 citations

Association of Campylobacter pylori with induced expression of class II transplantation antigens on gastric epithelial cells

1989 • 121 citations

GASTRITIS AND GASTRIC CANCER

2000 • 120 citations

Potentiation of Helicobacter pylori Vacuolating Toxin Activity by Nicotine and Other Weak Bases

1992 • 118 citations

Relationship of Helicobacter pylori CagA status to gastric cell proliferation and apoptosis.

1999 • 117 citations

Activation of Peroxisome Proliferator-activated Receptor γ Suppresses Nuclear Factor κB-mediated Apoptosis Induced by Helicobacter pylori in Gastric Epithelial Cells

2001 • 112 citations

Helicobacter pyloriModulates Lymphoepithelial Cell Interactions Leading to Epithelial Cell Damage through Fas/Fas Ligand Interactions

2000 • 107 citations

Mucosal interleukin-8 and Helicobacter pylori-associated gastroduodenal disease.

1994 • 105 citations

Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia

1997 • 92 citations

Carcinogenesis, apoptosis and cell proliferation

1998 • 92 citations

Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells

2000 • 91 citations

Heterogeneity in Levels of Vacuolating Cytotoxin Gene ( vacA ) Transcription among Helicobacter pylori Strains

1998 • 89 citations

Natural Diversity in the N Terminus of the Mature Vacuolating Cytotoxin of Helicobacter pylori Determines Cytotoxin Activity

2000 • 77 citations

Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway.

1999 • 71 citations

Ammonia-induced apoptosis is accelerated at higher pH in gastric surface mucous cells

2002 • 68 citations

Persistence ofHelicobacter pyloriVacA toxin and vacuolating potential in cultured gastric epithelial cells

1998 • 57 citations

Enhanced Disease Severity inHelicobacter pylori-Infected Mice Deficient in Fas Signaling

2002 • 53 citations

The Relationship Between Helicobacter pylori Infection, the Virulence Genotypes of the Infecting Strain and Gastric Cancer in the African Setting

2001 • 52 citations

In Vivo Disruption of the Fas Pathway Abrogates Gastric Growth Alterations Secondary toHelicobacterInfection

2000 • 45 citations

Helicobacter pyloriand Nucleolar Organizer Regions in the Gastric Antral Mucosa

1994 • 42 citations

Ammonia as an Accelerator of Tumor Necrosis Factor Alpha-Induced Apoptosis of Gastric Epithelial Cells in Helicobacter pylori Infection

2001 • 39 citations

Helicobacter pylorilipopolysaccharide induces apoptosis of cultured guinea pig gastric mucosal cells

2001 • 30 citations

Increase in apoptosis and decrease in ornithine decarboxylase activity of the gastric mucosa in patients with atrophic gastritis and gastric ulcer after successful eradication of Helicobacter pylori

1999 • 26 citations

In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection

2002 • 21 citations

Cited By (0)

Loading...
Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating… (2003) – PubMed | Metascience Observatory Explorer