A 12-Amino-Acid Segment, Present in Type s2 but Not Type s1 Helicobacter pylori VacA Proteins, Abolishes Cytotoxin Activity and Alters Membrane Channel Formation
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References (68)
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES
1943 • 2,733 citations
Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori
1995 • 1,551 citations
Helicobacter pylori
1997 • 1,044 citations
Purification and characterization of the vacuolating toxin from Helicobacter pylori.
1992 • 700 citations
Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
1988 • 681 citations
The Comprehensive Sourcebook of Bacterial Protein Toxins
2015 • 601 citations
Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.
1994 • 594 citations
Free recombination within Helicobacter pylori
1998 • 591 citations
Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin
1999 • 591 citations
Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains.
1995 • 534 citations
Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.
1994 • 490 citations
Geographic distribution of vacA allelic types of Helicobacter pylori
1999 • 455 citations
Chemical probes for anion transporters of mammalian cell membranes
1992 • 378 citations
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release
2000 • 354 citations
TOXCAT: A measure of transmembrane helix association in a biological membrane
1999 • 343 citations
Genetic analysis of the Helicobacter pylori vacuoiating cytotoxin: structural similarities with the IgA protease type of exported protein
1994 • 313 citations
The vacuolating cytotoxin of Helicobacter pylori
1996 • 288 citations
Virulence Factors of Helicobacter pylori Responsible for Gastric Diseases in Mongolian Gerbil
2000 • 285 citations
Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA
1998 • 282 citations
Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity
1999 • 269 citations
Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin
1991 • 253 citations
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
1998 • 245 citations
Vacuolating Cytotoxin of Helicobacter pylori Plays a Role during Colonization in a Mouse Model of Infection
2001 • 220 citations
Low pH Activates the Vacuolating Toxin of Helicobacter pylori, Which Becomes Acid and Pepsin Resistant
1995 • 217 citations
The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH
1999 • 212 citations
Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle.
1999 • 212 citations
Differential mRNA stability of the cspA gene in the cold‐shock response of Escherichia coli
1996 • 210 citations
Diversity of Helicobacter pylori vacA and cagA Genes and Relationship to VacA and CagA Protein Expression, Cytotoxin Production, and Associated Diseases
1998 • 210 citations
Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease
1995 • 204 citations
Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly
1997 • 199 citations
Principles of Bacterial Pathogenesis
2001 • 194 citations
Vacuoles Induced by Helicobacter pylori Toxin Contain Both Late Endosomal and Lysosomal Markers
1997 • 189 citations
The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity
1998 • 186 citations
Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin.
1996 • 185 citations
Dominant-Negative Mutants of a Toxin Subunit: An Approach to Therapy of Anthrax
2001 • 183 citations
Long-term colonization with single and multiple strains of Helicobacter pylori assessed by DNA fingerprinting
1995 • 182 citations
Activation of Helicobacter pylori VacA Toxin by Alkaline or Acid Conditions Increases Its Binding to a 250-kDa Receptor Protein-tyrosine Phosphatase β
1999 • 160 citations
Prevalence of Vacuolating Cytotoxin Production and Distribution of Distinct vacA Alleles in Helicobacter pylori from China
1998 • 157 citations
Helicobacter pylori Vacuolating Toxin Forms Anion-Selective Channels in Planar Lipid Bilayers: Possible Implications for the Mechanism of Cellular Vacuolation
1999 • 151 citations
Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa?
1999 • 146 citations
Multiple Strain Colonization and Metronidazole Resistance in Helicobacter pylori-Infected Patients: Identification from Sequential and Multiple Biopsy Specimens
1996 • 141 citations
VacA from Helicobacter pylori: a hexameric chloride channel
1999 • 139 citations
A Dominant Negative Mutant of Helicobacter pyloriVacuolating Toxin (VacA) Inhibits VacA-induced Cell Vacuolation
1999 • 131 citations
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.
1993 • 131 citations
Identification of the Helicobacter pylori VacA Toxin Domain Active in the Cell Cytosol
1998 • 114 citations
Identification of the Minimal Intracellular Vacuolating Domain of the Helicobacter pylori Vacuolating Toxin
1999 • 110 citations
Identification and Analysis of a New vacA Genotype Variant of Helicobacter pylori in Different Patient Groups in Germany
1998 • 99 citations
Introduction of unmarked mutations in the Helicobacter pylori vacA gene with a sucrose sensitivity marker
1997 • 97 citations
Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells
2000 • 91 citations
The Acid Activation ofHelicobacter pyloriToxin VacA: Structural and Membrane Binding Studies
1998 • 90 citations
Heterogeneity in Levels of Vacuolating Cytotoxin Gene ( vacA ) Transcription among Helicobacter pylori Strains
1998 • 89 citations
Helicobacter pylori -Associated Gastritis in Mice is Host and Strain Specific
1999 • 88 citations
Allelic Diversity of the Helicobacter pylori Vacuolating Cytotoxin Gene in South Africa: Rarity of the vacA s1a Genotype and Natural Occurrence of an s2/m1 Allele
1999 • 80 citations
Cell Specificity of Helicobacter pylori Cytotoxin Is Determined by a Short Region in the Polymorphic Midregion
2000 • 79 citations
Natural Diversity in the N Terminus of the Mature Vacuolating Cytotoxin of Helicobacter pylori Determines Cytotoxin Activity
2000 • 77 citations
Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori
1999 • 76 citations
Carboxy-Terminal Proteolytic Processing of Helicobacter pylori Vacuolating Toxin
2001 • 74 citations
Single and Multiple Strain Colonization in Patients with Helicobacter pylori Associated Gastritis: Detection by Macrorestriction DNA Analysis
1994 • 71 citations
A Dominant Negative Mutant of Bacillus anthracisProtective Antigen Inhibits Anthrax Toxin Action in Vivo
2001 • 69 citations
vacA Genotypes in Helicobacter pylori Strains Isolated from Children with and without Duodenal Ulcer in Brazil
2000 • 66 citations
The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein
2000 • 60 citations
vacA Genotypes and Genetic Diversity in Clinical Isolates of Helicobacter pylori
1998 • 58 citations
Amino-Terminal Hydrophobic Region of Helicobacter pylori Vacuolating Cytotoxin (VacA) Mediates Transmembrane Protein Dimerization
2001 • 53 citations
Mutational Analysis of the Helicobacter pylori Vacuolating Toxin Amino Terminus: Identification of Amino Acids Essential for Cellular Vacuolation
2000 • 45 citations
High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori
1997 • 34 citations
H. pylori Pathogenesis
2001 • 33 citations
Helicobacter pylori vacuolating cytotoxin and associated pathogenic factors
1999 • 23 citations
Functional Domains of Wild-Type and Mutant p53 Proteins Involved in Transcriptional Regulation, Transdominant Inhibition, and Transformation Suppression
1993 • 15 citations