The Effects of Legionella pneumophila Toxin on Oxidative Processes and Bacterial Killing of Human Polymorphonuclear Leukocytes

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES

1971 • 973 citations

In Vitro Bactericidal Capacity of Human Polymorphonuclear Leukocytes: Diminished Activity in Chronic Granulomatous Disease of Childhood *

1967 • 932 citations

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection

1969 • 697 citations

Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

1967 • 677 citations

Biochemical Aspects of Phagocytosis

1961 • 657 citations

Legionnaires' Disease Bacterium (Legionella pneumophila) Multiplies Intracellularly in Human Monocytes

1980 • 648 citations

Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.

1975 • 583 citations

Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival.

1975 • 528 citations

THE INTERACTION BETWEEN TOXOPLASMA GONDII AND MAMMALIAN CELLS

1972 • 527 citations

Metabolic Basis of Phagocytic Activity

1962 • 484 citations

Method of determining oxygen concentrations in biological media, suitable for calibration of the oxygen electrode

1970 • 382 citations

Defective Superoxide Production by Granulocytes from Patients with Chronic Granulomatous Disease

1974 • 375 citations

Catalase, superoxide dismutase, and virulence of Staphylococcus aureus. In vitro and in vivo studies with emphasis on staphylococcal--leukocyte interaction.

1975 • 324 citations

Effects of Sulfhydryl Inhibition on Red Blood Cells

1966 • 287 citations

STIMULATION OF THE GLUCOSE OXIDATIVE PATHWAY IN HUMAN ERYTHROCYTES BY METHYLENE BLUE

1958 • 268 citations

Fusion of Host Cell Secondary Lysosomes with the Parasitophorous Vacuoles ofLeishmania mexicana-inlected Macrophages

1975 • 266 citations

Influence of the Escherichia coli capsule on complement fixation and on phagocytosis and killing by human phagocytes.

1980 • 264 citations

Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes.

1972 • 236 citations

Disc electrophoresis of ribonucleic acid in polyacrylamide gels

1965 • 233 citations

The pathology of the legionella pneumonias

1981 • 214 citations

Complete Deficiency of Leukocyte Glucose-6-Phosphate Dehydrogenase with Defective Bactericidal Activity

1972 • 214 citations

Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.

1980 • 198 citations

Ultrastructural Study of the Behavior of Macrophages Toward Parasitic Mycobacteria

1972 • 181 citations

Interaction of the legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication.

1981 • 169 citations

Interaction of the legionnaires' disease bacterium (legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclearleukocytes, antibody, and complement

1981 • 162 citations

PHAGOCYTE LYSOSOMES: INTERACTIONS WITH INFECTIOUS AGENTS, PHAGOSOMES, AND EXPERIMENTAL PERTURBATIONS IN FUNCTION

1977 • 127 citations

"Endotoxicity" of the Legionnaires' Disease Bacterium

1979 • 125 citations

Growth of Legionnaires disease bacterium (Legionella pneumophila) in chemically defined medium

1979 • 116 citations

Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease

1970 • 112 citations

A Variant of Chronic Granulomatous Disease: Deficient Oxidative Metabolism Due to a Low-Affinity NADPH Oxidase

1981 • 106 citations

Defective Initiation of Oxidative Metabolism in Polymorphonuclear Leukocytes

1979 • 89 citations

The pathology of Legionnaires' disease. Fourteen fatal cases from the 1977 outbreak in Vermont.

1978 • 84 citations

Oxidative Peptide Cleavage and Decarboxylation by the MPO-H ₂ O ₂ -Cl ⁻ Antimicrobial System

1974 • 80 citations

Identification of a cytotoxin produced by Legionella pneumophila

1980 • 76 citations

Legionnaires' disease. Pathological and historical aspects of a 'new' disease.

1978 • 75 citations

Exotoxin activity associated with the Legionnaires disease bacterium

1979 • 61 citations

Oxidative Bactericidal Mechanisms of Polymorphonuclear Leukocytes

1975 • 60 citations

In vitro responses of guinea pig peritoneal macrophages to Legionella pneumophila

1981 • 56 citations

Proteolytic action of Legionella pneumophila on human serum proteins

1980 • 53 citations

Intracellular Replication of Legionella pneumophila

1981 • 48 citations

In vitro interaction between normal cynolmolgus monkey alveolar macrophages and Legionnaires disease bacteria

1979 • 46 citations

Extracellular enzymes of Legionella pneumophila

1981 • 46 citations

In Vitro Production of an Extracellular Protease by Legionella pneumophila

1981 • 46 citations

Intracellular multiplication of Legionella pneumophila in cultured human embryonic lung fibroblasts

1980 • 41 citations

Pathologic Findings in Guinea Pigs Inoculated lntraperitoneally with the Legionnaires' Disease Bacterium

1979 • 39 citations

Biochemical aspects of phagocytic cells as related to bactericidal function.

1972 • 27 citations

Growth of the Pittsburgh Pneumonia Agent in Animal Cell Cultures

1981 • 15 citations