HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing.

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

The Immunopathogenesis of Human Immunodeficiency Virus Infection

1993 • 1,194 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Negative selection of lymphocytes

1994 • 810 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

1990 • 605 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

T cells can present antigens such as HIV gp120 targeted to their own surface molecules

1988 • 294 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

How some T cells escape tolerance induction

1989 • 216 citations

T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?

1993 • 183 citations

Recognition of hepatitis B virus envelope proteins by liver-infiltrating T lymphocytes in chronic HBV infection.

1989 • 170 citations

Suppressive effect of antibody on processing of T cell epitopes.

1993 • 166 citations

The inability to process a self-peptide allows autoreactive T cells to escape tolerance.

1993 • 127 citations

Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4

1991 • 120 citations

Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen.

1994 • 116 citations

Professional presentation of antigen by activated human T cells

1994 • 112 citations

A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts.

1994 • 110 citations

Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes.

1992 • 98 citations

Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule.

1989 • 76 citations

Recognition of peptides that are immunopathogenic but cryptic. Mechanisms that allow lymphocytes sensitized against cryptic peptides to initiate pathogenic autoimmune processes.

1991 • 65 citations

Antibodies to CD4 in individuals infected with human immunodeficiency virus type 1.

1989 • 62 citations

Analysis of HIV-induced autoantibodies to cryptic epitopes on human CD4.

1992 • 34 citations

Biological properties of anti-CD4 autoantibodies purified from HIV-infected patients.

1991 • 26 citations