Identification of Activating c-kit Mutations in Adult-, but not in Childhood-Onset Indolent Mastocytosis: A Possible Explanation for Divergent Clinical Behavior

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.

1995 • 895 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.

1993 • 835 citations

Establishment of an immature mast cell line from a patient with mast cell leukemia

1988 • 749 citations

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1988 • 727 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

1996 • 625 citations

Systemic Mast Cell Disease

1988 • 485 citations

Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture

1992 • 436 citations

Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells.

1991 • 369 citations

Classification and Diagnosis of Mastocytosis: Current Status

1991 • 353 citations

Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines

1995 • 291 citations

Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo.

1996 • 273 citations

Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis

1993 • 261 citations

A new leukemia cell line with philadelphia chromosome characterized as basophil precursors

1985 • 261 citations

Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation

1994 • 217 citations

Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology.

1988 • 190 citations

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

1996 • 168 citations

c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas.

1992 • 167 citations

Mastocytosis and the Mast Cell

1968 • 167 citations

Urticaria Pigmentosa: A Review of 67 Pediatric Cases

1994 • 140 citations

Mastocytosis and the Mast Cell

1967 • 136 citations

A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells

1996 • 135 citations

Substitution of an Aspartic Acid Results in Constitutive Activation of c-<i>kit</i>Receptor Tyrosine Kinase in a Rat Tumor Mast Cell Line RBL-2H3

1995 • 127 citations

Mastocytosis

1997 • 95 citations

<i>c-ki</i><i>t</i> Mutation in a Population of Patients with Mastocytosis

1997 • 76 citations

Urticaria pigmentosa: clinical picture and response to oral disodium cromoglycate

1981 • 76 citations

Pigmentation and Proliferation of Human Melanocytes and the Effects of Melanocyte‐Stimulating Hormone and Ultraviolet B Light^a

1993 • 65 citations

Effects of nerve growth factor (NGF) and other fibroblast-derived growth factors on immature human mast cells (HMC-1).

1998 • 62 citations

Expression of stem cell factor in cutaneous mastocytosis

1995 • 62 citations

Bone marrow findings in adult patients with urticaria pigmentosa

1988 • 58 citations

Trisomies 9 and 8 detected by fluorescence in situ hybridization in patients with systemic mastocytosis

1996 • 36 citations

Mechanisms of constitutive activation of c-kit receptor tyrosine kinase.

1997 • 32 citations

Mast cells in the cytokine network: the what, where from and what for

1995 • 25 citations

Clinical advances in mastocytosis

1995 • 16 citations