The p53 tumor suppressor gene frequently is altered in gynecologic cancers

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case -Control Studies

1992 • 995 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis

1990 • 773 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Overexpression and mutation of p53 in epithelial ovarian cancer.

1991 • 464 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

1992 • 313 citations

p53 gene mutations and protein accumulation in human ovarian cancer.

1993 • 294 citations

p53 point mutation in HPV negative human cervical carcinoma cell lines.

1991 • 271 citations

Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA

1990 • 270 citations

p53 gene mutations in Barrett's epithelium and esophageal cancer.

1991 • 266 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease

1991 • 250 citations

Overexpression and mutation of p53 in endometrial carcinoma.

1992 • 227 citations

Human p53 gene localized to short arm of chromosome 17

1986 • 222 citations

The epidemiology of ovarian cancer

1991 • 214 citations

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis.

1992 • 198 citations

Frequent allelic losses and mutations of the p53 gene in human ovarian cancer.

1991 • 194 citations

Spectrum of Mutation and Frequency of Allelic Deletion of the p53 Gene in Ovarian Cancer

1993 • 184 citations

Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection.

1992 • 177 citations

Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.

1993 • 176 citations

Mutation and overexpression of p53 in early-stage epithelial ovarian cancer.

1993 • 168 citations

Clonal Origin of Epithelial Ovarian Carcinoma: Analysis by Loss of Heterozygosity, p53 Mutation, and X-Chromosome Inactivation

1992 • 157 citations

Allele loss from chromosome 17 in ovarian cancer.

1990 • 156 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

Expression of p53 protein in colorectal cancer and its relationship to short-term prognosis

1992 • 140 citations

Mutations causing hemophilia B: direct estimate of the underlying rates of spontaneous germ-line transitions, transversions, and deletions in a human gene.

1990 • 137 citations

Allele losses on chromosome 17 in human epithelial ovarian carcinoma.

1990 • 121 citations

Allelic loss on chromosome 17p and p53 mutations in human endometrial carcinoma of the uterus.

1991 • 118 citations

p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.

1992 • 109 citations

Unifocal origin of advanced human epithelial ovarian cancers.

1992 • 108 citations

High Incidence of p53 Gene Mutation in Human Ovarian Cancer and Its Association with Nuclear Accumulation of p53 Protein and Tumor DNA Aneuploidy

1992 • 101 citations

High level expression of fms proto-oncogene mRNA is observed in clinically aggressive human endometrial adenocarcinomas

1988 • 84 citations

p53 gene mutations in human endometrial carcinoma

1992 • 80 citations

The Epidemiology of Ovarian Cancer

1992 • 55 citations

Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias

1993 • 53 citations

The pattern of factor IX germ-line mutation in Asians is similar to that of Caucasians.

1990 • 46 citations

Detection of genes that are differentially expressed during mouse embryogenesis by genetic trapping strategies

1993 • 3 citations