The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

p53 function and dysfunction

1992 • 1,918 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Rapid transfer of DNA from agarose gels to nylon membranes

1985 • 1,810 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

1981 • 1,429 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Distinctive Chromosomal Abnormalities in Histologic Subtypes of Non-Hodgkin's Lymphoma

1982 • 642 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Imaging plate illuminates many fields

1988 • 495 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Frequent mutation of the p53 gene in human esophageal cancer.

1990 • 393 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

MDM2 gene amplification in metastatic osteosarcoma.

1993 • 340 citations

Cytogenetic studies of adipose tissue tumors. II. Recurrent reciprocal translocation t(12;16)(q13;p11) in myxoid liposarcomas

1986 • 226 citations

Chronic Lymphocytic Leukaemia: Proposals for a Revised Prognostic Staging System.

1981 • 219 citations

Cytogenetic analysis of 434 consecutively ascertained specimens of non- Hodgkin's lymphoma: clinical correlations

1991 • 217 citations

Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation

1980 • 201 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

Prognostic Importance of Cytogenetic Abnormalities in Patients with Chronic Lymphocytic Leukemia

1984 • 168 citations

Mutations of p53 gene and their relation to disease progression in B- cell lymphoma

1992 • 166 citations

Chromosome aberrations in B-cell chronic lymphocytic leukemia

1990 • 144 citations

Prognostic information from cytogenetic analysis in chronic B- lymphocytic leukemia and leukemic immunocytoma

1985 • 143 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 138 citations

Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS- derived leukemia

1993 • 128 citations

Isolation of human T and B lymphocytes by E-rosette gradient centrifugation. Characterization of the isolated subpopulations

1980 • 126 citations

The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma.

1993 • 124 citations

Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia

1984 • 118 citations

Characteristic karyotypic anomalies identify subtypes of malignant fibrous histiocytoma

1989 • 116 citations

Mutations of the p53 gene in lymphoid leukemia

1991 • 104 citations

Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors.

1991 • 79 citations

Consistency of chromosomal aberrations in chronic B-lymphocytic leukemia. A longitudinal cytogenetic study of 41 patients

1988 • 74 citations

Erythroid potentiating activity of tissue inhibitor of metalloproteinases on the differentiation of erythropoietin-responsive mouse erythroleukemia cell line, ELM-I-1-3, is closely related to its cell growth potentiating activity.

1993 • 41 citations

Remission induction of acute promyelocytic leukemia by all-trans-retinoic acid: molecular evidence of restoration of normal hematopoiesis after differentiation and subsequent extinction of leukemic clone.

1992 • 41 citations