The IGF system in thyroid cancer: new concepts

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors

1992 • 535 citations

Functionally distinct insulin receptors generated by tissue-specific alternative splicing.

1990 • 356 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism

1999 • 280 citations

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

1993 • 271 citations

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.

1999 • 254 citations

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

1997 • 234 citations

Molecular Basis of Thyroid Cancer*

1994 • 232 citations

Insulin receptor expression and function in human breast cancer cell lines.

1992 • 202 citations

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

1990 • 199 citations

Human thyrotropin receptor gene: Expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation

1991 • 143 citations

Insulin and IGF-I Receptors Signaling in Protection from Apoptosis

1999 • 133 citations

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.

1995 • 126 citations

Expression of Growth Factors and Growth Factor Receptors in Normal and Tumorous Human Thyroid Tissues

1995 • 114 citations

Insulin/IGF-I hybrid receptors play a major role in IGF-I signaling in thyroid cancer

1999 • 102 citations

Overexpression of Insulin Receptors in Fibroblast and Ovary Cells Induces a Ligand-Mediated Transformed Phenotype

1991 • 92 citations

Negative/Low Expression of the Met/Hepatocyte Growth Factor Receptor Identifies Papillary Thyroid Carcinomas with High Risk of Distant Metastases¹

1997 • 83 citations

Expression of c-erbB-2 protein in papillary thyroid carcinomas

1992 • 78 citations

Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification

1993 • 78 citations

Epidermal Growth Factor Receptors in Plasma Membranes of Normal and Diseased Human Thyroid Glands

1989 • 53 citations

Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation.

1994 • 46 citations

Functional insulin receptors are overexpressed in thyroid tumors

1999 • 43 citations

The insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells.

1989 • 36 citations

Effect of TSH in human thyroid cells: Evidence for both mitogenic and antimitogenic effects

1992 • 33 citations

Insulin Receptor

1997 • 33 citations

Insulin-Like Growth Factor-I Receptors in Nonfunctioning Thyroid Nodules*

1990 • 27 citations