Cooperative helix stabilization by complex Arg–Glu salt bridges

NMR with Proteins and Nucleic Acids

1986 • 7,896 citations

NMR of Proteins and Nucleic Acids

2006 • 5,989 citations

Investigation of exchange processes by two-dimensional NMR spectroscopy

1979 • 4,720 citations

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

1992 • 3,627 citations

MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy

1985 • 3,603 citations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants

1982 • 2,567 citations

Cation-π interactions in structural biology

1999 • 1,900 citations

A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules

1980 • 1,886 citations

Proteins. Structures and molecular properties

1984 • 1,247 citations

Study of Moderately Rapid Chemical Exchange Reactions by Means of Nuclear Magnetic Double Resonance

1963 • 1,199 citations

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

1987 • 930 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

Unusually stable helix formation in short alanine-based peptides.

1989 • 752 citations

Folding of immunogenic peptide fragments of proteins in water solution

1988 • 735 citations

Electrostatic Effects in Proteins

1978 • 734 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

Helix propensities of the amino acids measured in alanine‐based peptides without helix‐stabilizing side‐chain interactions

1994 • 601 citations

Tests of the helix dipole model for stabilization of α-helices

1987 • 598 citations

The role of the α-helix dipole in protein function and structure

1985 • 517 citations

pH-Induced denaturation of proteins: a single salt bridge contributes 3-5 kcal/mol to the free energy of folding of T4 lysozyme

1990 • 503 citations

The Mechanism of alpha-Helix Formation by Peptides

1992 • 492 citations

Parameters of helix–coil transition theory for alanine‐based peptides of varying chain lengths in water

1991 • 490 citations

Strength and co-operativity of contributions of surface salt bridges to protein stability

1990 • 415 citations

Development of the multiple sequence approximation within the AGADIR model of α-helix formation: Comparison with Zimm-Bragg and Lifson-Roig formalisms

1997 • 397 citations

Two-Point Calibration of Circular Dichrometer with d-10-Camphorsulfonic Acid

1977 • 390 citations

Are buried salt bridges important for protein stability and conformational specificity?

1995 • 323 citations

Theoretical CD studies of polypeptide helices: Examination of important electronic and geometric factors

1991 • 320 citations

Roles of electrostatic interaction in proteins

1996 • 300 citations

Helix stop signals in proteins and peptides: The capping box

1993 • 297 citations

Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme

1991 • 265 citations

The energetics of ion-pair and hydrogen-bonding interactions in a helical peptide

1993 • 260 citations

Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis

1991 • 238 citations

Solution conformation of the ferrichromes. VI. Charge relay at the peptide bond. Proton magnetic resonance study of solvation effects on the amide electron density distribution

1975 • 216 citations

The helix–coil transition in heterogeneous peptides with specific side‐chain interactions: Theory and comparison with CD spectral data

1991 • 201 citations

Complex Salt Bridges in Proteins: Statistical Analysis of Structure and Function

1995 • 187 citations

Polyalanine-Based Peptides as Models for Self-Associated β-Pleated-Sheet Complexes

1997 • 173 citations

Derivative spectroscopy applied to tyrosyl chromophores. Ribonuclease, lima bean inhibitors, insulin, and pancreatic trypsin inhibitor

1973 • 167 citations

Conformational studies of poly‐<scp>L</scp>‐alanine in water

1968 • 149 citations

Determinants of protein thermostability observed in the 1.9-.ANG. crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus

1993 • 138 citations

Direct measurement of salt-bridge solvation energies using a peptide model system: implications for protein stability.

1996 • 130 citations

Inter-helical interactions in the leucine zipper coiled coil dimer: ph and salt dependence of coupling energy between charged amino acids

1998 • 126 citations

Insights into the molecular basis of thermal stability from the analysis of ion‐pair networks in the Glutamate Dehydrogenase family

1998 • 124 citations

Helical peptides with three pairs of Asp‐Arg and Glu‐Arg residues in different orientations and spacings

1993 • 122 citations

Energetic contribution of solvent-exposed ion pairs to alpha-helix structure

1992 • 119 citations

Alanine Is an Intrinsic α-Helix Stabilizing Amino Acid

1999 • 101 citations

Solution conformation of ferrichrome, a microbial iron transport cyclohexapeptide, as deduced by high resolution proton magnetic resonance

1970 • 96 citations

Surface salt bridges stabilize the GCN4 leucine zipper

1998 • 92 citations

Energetics of Polar Side-Chain Interactions in Helical Peptides: Salt Effects on Ion Pairs and Hydrogen Bonds

1998 • 92 citations

Composite Z pulses

1981 • 73 citations

Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. II: construction of a 16-residue ion-pair network at the subunit interface

1999 • 68 citations

Strength of Solvent-Exposed Salt-Bridges

1999 • 66 citations

Helix Propensities of Basic Amino Acids Increase with the Length of the Side-chain

1996 • 66 citations

Ion-Pair and Charged Hydrogen-Bond Interactions between Histidine and Aspartate in a Peptide Helix

1997 • 62 citations

CD Spectroscopy and the Helix-Coil Transition in Peptides and Polypeptides

1996 • 61 citations

Analysis of asymmetry in the distribution of helical residues in peptides by proton nuclear magnetic resonance

1991 • 57 citations

Template-nucleated alanine-lysine helices are stabilized by position-dependent interactions between the lysine side chain and the helix barrel.

1996 • 52 citations

α-Helix Nucleation Constant in Copolypeptides of Alanine and Ornithine or Lysine

1998 • 46 citations

Stabilizing Effect of a Multiple Salt Bridge in a Prenucleated Peptide

1998 • 44 citations

Nuclear magnetic resonance studies of exchangeable protons. I. Fourier transform saturation-recovery and transfer of saturation of the tryptophan indole nitrogen proton

1975 • 44 citations

Structural analysis of the N‐ and C‐termini in a peptide with consensus sequence

1995 • 37 citations

Atomic environments of arginine side chains in proteins

1993 • 37 citations

Two Interaction Modes of the gp41-Derived Peptides with gp41 and Their Correlation with Antimembrane Fusion Activity

1999 • 19 citations

Arg side-chain-backbone interactions evidenced in model peptides by17O-NMR spectroscopy

2000 • 8 citations