Energetic contribution of solvent-exposed ion pairs to alpha-helix structure

Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains

1959 • 1,756 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

1990 • 1,173 citations

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

1987 • 930 citations

Temperature dependence of the hydrophobic interaction in protein folding.

1986 • 865 citations

Unusually stable helix formation in short alanine-based peptides.

1989 • 752 citations

Electrostatic Effects in Proteins

1978 • 734 citations

Ion-pairs in proteins

1983 • 687 citations

Tests of the helix dipole model for stabilization of α-helices

1987 • 598 citations

Secondary Structure of Proteins Through Circular Dichroism Spectroscopy

1988 • 537 citations

pH-Induced denaturation of proteins: a single salt bridge contributes 3-5 kcal/mol to the free energy of folding of T4 lysozyme

1990 • 503 citations

Side Chain Contributions to the Stability of Alpha-Helical Structure in Peptides

1990 • 455 citations

Structure and mechanism of chymotrypsin

1976 • 449 citations

Two-Point Calibration of Circular Dichrometer with d-10-Camphorsulfonic Acid

1977 • 390 citations

Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

1990 • 372 citations

Capping and α-helix stability

1989 • 363 citations

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

1990 • 350 citations

Large differences in the helix propensities of alanine and glycine

1991 • 307 citations

Enhanced protein thermostability from designed mutations that interact with α-helix dipoles

1988 • 290 citations

Conformational equilibria in α- and δ-chymotrypsin

1972 • 250 citations

Theory of protein secondary structure and algorithm of its prediction

1983 • 241 citations

The helix–coil transition in heterogeneous peptides with specific side‐chain interactions: Theory and comparison with CD spectral data

1991 • 201 citations

Alpha-helix stabilization by natural and unnatural amino acids with alkyl side chains.

1991 • 186 citations

Surface electrostatic interactions contribute little to stability of barnase

1991 • 168 citations

Studies of synthetic helical peptides using circular dichroism and nuclear magnetic resonance

1990 • 167 citations

Derivative spectroscopy applied to tyrosyl chromophores. Ribonuclease, lima bean inhibitors, insulin, and pancreatic trypsin inhibitor

1973 • 167 citations

Circular Dichroism of Peptides

1985 • 162 citations

Helix-coil stability constants for the naturally occurring amino acids in water. 22. Histidine parameters from random poly[(hydroxybutyl)glutamine-co-L-histidine]

1984 • 162 citations

The Influence of a Single Salt Bridge on Static and Dynamic Features of the Globular Solution Conformation of the Basic Pancreatic Trypsin Inhibitor. 1H and 13C Nuclear-Magnetic-Resonance Studies of the Native and the Transaminated Inhibitor

1978 • 104 citations

The Effect of Neighboring Charges on the Helix Forming Ability of Charged Amino Acids in Proteins

1975 • 70 citations

Thermodynamic parameters of helix‐coil transition in polypeptide chains I. Poly‐(<scp>L</scp>‐glutamic acid)

1971 • 63 citations

Thermodynamic parameters of helix–coil transition in polypeptide chains. II. Poly‐<scp>L</scp>‐lysine

1971 • 61 citations

Analysis of asymmetry in the distribution of helical residues in peptides by proton nuclear magnetic resonance

1991 • 57 citations

The role of ion pairs in .alpha. helix stability: two new designed helical peptides

1989 • 53 citations

Helix–coil transition theory including long‐range electrostatic interactions: Application to globular proteins

1987 • 51 citations

On the fundamental role of the glu 2−…Arg 10+ salt bridge in the folding of isolated ribonuclease a S-peptide

1984 • 50 citations

Mechanism of denaturation of haemoglobin by alkali

1974 • 48 citations

Local effect of glycine substitution in a model helical peptide

1991 • 32 citations

Allosteric energy at the hemoglobin beta chain C terminus studied by hydrogen exchange

1988 • 30 citations

Assembly of tobacco mosaic virus.

1972 • 25 citations

Stereochemistry of salt‐bridge formation in α‐helices and β‐strands

1988 • 15 citations

Stabilization of alpha helices by ion pairs

1987 • 4 citations

Distribution of Charged Residues Stabilizes Individual Helices in Myoglobins

1990 • 1 citations