Constitutive Activation of the Cyclic Adenosine 3′,5′-Monophosphate Signaling Pathway by Parathyroid Hormone (PTH)/PTH-Related Peptide Receptors Mutated at the Two Loci for Jansen’s Metaphyseal Chondrodysplasia

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

1991 • 1,230 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A Constitutively Active Mutant PTH-PTHrP Receptor in Jansen-Type Metaphyseal Chondrodysplasia

1995 • 668 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor

1991 • 458 citations

Molecular cloning and expression of a cDNA encoding the secretin receptor.

1991 • 415 citations

Identification and Functional Expression of a Receptor Selectively Recognizing Parathyroid Hormone, the PTH2 Receptor

1995 • 414 citations

Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.

1992 • 327 citations

Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors

1993 • 320 citations

Constitutively Activated Receptors for Parathyroid Hormone and Parathyroid Hormone–Related Peptide in Jansen's Metaphyseal Chondrodysplasia

1996 • 293 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

1994 • 224 citations

Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone

1992 • 222 citations

Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.

1993 • 193 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Transmembrane Regions V and VI of the Human Luteinizing Hormone Receptor Are Required for Constitutive Activation by a Mutation in the Third Intracellular Loop

1996 • 122 citations

Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.

1994 • 113 citations

A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty.

1995 • 110 citations

Pseudohypoparathyroidism type Ib is not caused by mutations in the coding exons of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene.

1995 • 110 citations

Truncation of the Carboxyl-terminal Region of the Rat Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Enhances PTH Stimulation of Adenylyl Cyclase but Not Phospholipase C

1995 • 100 citations

Transmembrane Residues of the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor That Specifically Affect Binding and Signaling by Agonist Ligands

1996 • 92 citations

The Role of Asp578 in Maintaining the Inactive Conformation of the Human Lutropin/Choriogonadotropin Receptor

1996 • 86 citations

G protein-coupled receptor structure and function: The impact of disease-causing mutations

1995 • 83 citations

Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone???related peptide receptor: a member of an ancient family of G protein???coupled receptors

1994 • 82 citations

Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.

1996 • 74 citations

Point Mutations in the First and Third Intracellular Loops of the Glucagon-like Peptide-1 Receptor Alter Intracellular Signaling

1996 • 59 citations

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor.

1996 • 46 citations

Hypercalcemia due to constitutive activity of the parathyroid hormone (PTH)/PTH-related peptide receptor: comparison with primary hyperparathyroidism.

1996 • 42 citations

Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells.

1996 • 39 citations

Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells

1996 • 32 citations

Human Calcitonin Receptors Exhibit Agonist-Independent (Constitutive) Signaling Activity¹

1997 • 30 citations

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor

1996 • 27 citations