Cellular and molecular biological aspects of human bronchogenic carcinogenesis

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

Cancer Epidemiology and Prevention

2006 • 3,228 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Diffuse Pleural Mesothelioma and Asbestos Exposure in the North Western Cape Province

1960 • 1,825 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

1954 • 1,475 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

The age distribution of cancer and a multi-stage theory of carcinogenesis

2004 • 1,306 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Mutation and Cancer: A Model for Human Carcinogenesis2

1981 • 1,102 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

1986 • 958 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Cancer Epidemiology and Prevention.

1983 • 931 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

DNA Repair in Bacteria and Mammalian Cells

1979 • 854 citations

Expression of Cellular Oncogenes in Human Malignancies

1984 • 840 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

1988 • 781 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke

1988 • 689 citations

Evolution of tumours and the impact of molecular oncology

1985 • 666 citations

Some Biological Aspects of Skin Carcinogenesis*

2015 • 640 citations

Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma

1987 • 638 citations

The Immotile-Cilia Syndrome

1977 • 635 citations

Viral oncogenes

1985 • 605 citations

Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

1986 • 570 citations

A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer

1957 • 553 citations

Detection of Single Base Substitutions by Ribonuclease Cleavage at Mismatches in RNA:DNA Duplexes

1985 • 538 citations

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour

1984 • 538 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma

1986 • 524 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

Retinoblastoma: Clues to Human Oncogenesis

1984 • 495 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.

1987 • 487 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

Oncogenes in solid human tumours

1982 • 467 citations

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1988 • 465 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

1988 • 430 citations

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours

1984 • 426 citations

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

1981 • 415 citations

Development of homozygosity for chromosome 11p markers in Wilms' tumour

1984 • 411 citations

Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression

1987 • 407 citations

XERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICS

1975 • 406 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Mechanisms for the autoxidation of polyunsaturated lipids

1986 • 399 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

Detection of single base substitutions in total genomic DNA

1985 • 375 citations

Chemical Mutagenesis

1982 • 366 citations

Loss of genes on the short arm of chromosome 11 in bladder cancer

1985 • 360 citations

Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells

1984 • 354 citations

Human Cell Hybrids: Analysis of Transformation and Tumorigenicity

1982 • 349 citations

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

1985 • 344 citations

Loss of a Harvey ras allele in sporadic Wilms' tumour

1984 • 336 citations

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation

1984 • 333 citations

Viruses in naturally occurring cancers

1980 • 333 citations

Molecular Analysis of the Short Arm of Chromosome 3 in Small-Cell and Non-Small-Cell Carcinoma of the Lung

1987 • 331 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

1985 • 320 citations

A nonrandom chromosomal abnormality, del 3p(14–23), in human small cell lung cancer (SCLC)

1982 • 318 citations

Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties.

1980 • 317 citations

Experimental production of carcinoma with cigarette tar.

1953 • 300 citations

Detection of Mutagenic Activity in Cigarette Smoke Condensates

1974 • 284 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Sequence of the Alpha Subunit of Photoreceptor G Protein: Homologies Between Transducin, ras , and Elongation Factors

1985 • 276 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

Regulation of heat shock protein 70 gene expression by c-myc

1984 • 270 citations

Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus

1979 • 270 citations

Chemical Carcinogenesis: From Animal Models To Molecular Models In One Decade

1988 • 270 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Multistage Models and Primary Prevention of Cancer

1980 • 262 citations

Long-Term Mortality Study of Steelworkers

1971 • 261 citations

Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes.

1981 • 261 citations

Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1982 • 237 citations

Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.

1989 • 237 citations

Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis

1981 • 228 citations

Asbestos-associated chromosomal changes in human mesothelial cells.

1985 • 208 citations

An epidemiological perspective of the biology of cancer.

1978 • 201 citations

Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA.

1988 • 200 citations

Transformation of Human Bronchial Epithelial Cells Transfected by Harvey ras Oncogene

1985 • 198 citations

Growth factors produced by sarcoma virus-transformed cells.

1978 • 191 citations

Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers.

1985 • 190 citations

Carcinogenic effects of metals.

1978 • 178 citations

Formaldehyde Damage to DNA and Inhibition of DNA Repair in Human Bronchial Cells

1983 • 176 citations

Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines.

1987 • 176 citations

The analysis of malignancy by cell fusion: the position in 1988.

1988 • 173 citations

Relationship between the Epstein‐Barr virus and undifferentiated nasopharyngeal carcinoma: Correlated nucleic acid hybridization and histopathological examination

1977 • 173 citations

Enzyme action at 3' termini of ionizing radiation-induced DNA strand breaks.

1983 • 171 citations

Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers.

1988 • 170 citations

DNA ligase I deficiency in Bloom's syndrome

1987 • 169 citations

Methods in Cancer Research

1956 • 163 citations

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

1987 • 162 citations

Multiple-Mutation Theory of Carcinogenesis

1958 • 162 citations

GTP-binding proteins: One molecular machine can transduce diverse signals

1986 • 157 citations

Hydroxymethyluracil DNA glycosylase in mammalian cells.

1984 • 157 citations

Flagellar mutants in man: On the heterogeneity of the immotile-cilia syndrome

1979 • 149 citations

Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay.

1980 • 149 citations

Resistance of human cells to tumorigenesis induced by cloned transforming genes.

1983 • 147 citations

Genotoxicity of tobacco smoke and tobacco smoke condensate

1983 • 145 citations

Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21

1984 • 144 citations

Epidemiology of mesothelioma from estimated incidence

1977 • 140 citations

Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells

1979 • 137 citations

Relative Difficulties in Transforming Human and Animal Cells in Vitro

1983 • 136 citations

Pathobiological effects of acrolein in cultured human bronchial epithelial cells.

1988 • 135 citations

Involvement of chromosome 7 in primary lung tumor and nonmalignant normal lung tissue

1989 • 131 citations

Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency.

1984 • 130 citations

Detection of benzo(a)pyrene:DNA adducts in human white blood cells.

1985 • 130 citations

Oxygen and Living Processes: An Interdisciplinary Approach

2011 • 130 citations

Current concepts and controversies in chemical carcinogenesis

1981 • 126 citations

Chemical and biochemical dosimetry of exposure to genotoxic chemicals.

1985 • 122 citations

Ionizing radiation and tritium transmutation both cause formation of 5-hydroxymethyl-2'-deoxyuridine in cellular DNA.

1984 • 116 citations

Establishment of continuous cultures of Thy1.2+, Lytl+,2−T cells with purified interleukin 3

1981 • 112 citations

Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.

1988 • 111 citations

Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferation.

1988 • 106 citations

Detection of benzo[a]pyrene diol epoxide-DNA adducts in human placenta.

1988 • 104 citations

Papilloma viruses: Molecular and clinical aspects

1985 • 102 citations

Strontium phosphate transfection of human cells in primary culture: stable expression of the simian virus 40 large-T-antigen gene in primary human bronchial epithelial cells.

1987 • 101 citations

Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial epithelial cells.

1983 • 99 citations

Autogenous production of a hemopoietic growth factor, persisting-cell-stimulating factor, as a mechanism for transformation of bone marrow-derived cells.

1983 • 97 citations

Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells.

1986 • 94 citations

Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral harvey ras

1988 • 81 citations

Evolution of cancer genes as a mutation-driven process.

1988 • 79 citations

Production of Lung Cancer in Mice by Inhalation Exposure to Influenza Virus and Aerosols of Hydrocarbons* **

2015 • 77 citations

The Biology and chemistry of active oxygen

1984 • 76 citations

Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: altered response to inducers of terminal squamous differentiation.

1988 • 76 citations

A subpopulation of cultured human keratinocytes which is resistant to the induction of terminal differentiation-related changes by phorbol, 12-myristate, 13-acetate: evidence for an increase in the resistant population following transformation

1983 • 75 citations

Effects of formaldehyde, acetaldehyde, benzoyl peroxide, and hydrogen peroxide on cultured normal human bronchial epithelial cells.

1985 • 75 citations

Biochemical and molecular epidemiology of cancer

1985 • 71 citations

Induction of Lung Cancer in Germfree, Specific-Pathogen-Free, and Infected Rats by <italic>N</italic>-Nitrosoheptamethyleneimine: Enhancement by Respiratory Infection<xref ref-type="fn" rid="FN2">2</xref>

1972 • 66 citations

Suppression of tumorigenicity in somatic cell hybrids

1986 • 65 citations

Urea-DNA glycosylase in mammalian cells

1983 • 62 citations

Uranium mining and cigarette smoking effects on man.

1973 • 62 citations

Two Anonymous DNA Segments Distinguish the Wilms' Tumor and Aniridia Loci

1988 • 59 citations

Future directions in the use of DNA adducts as internal dosimeters for monitoring human exposure to environmental mutagens and carcinogens.

1985 • 59 citations

Analysis of DNA adducts by 32 P labeling and thin layer chromatography

1988 • 59 citations

Differential effects of 12-O-tetradecanoylphorbol-13-acetate on cultured normal and neoplastic human bronchial epithelial cells.

1984 • 58 citations

Simian Virus 40 (SV-40): An Oncogenic Virus

2015 • 58 citations

Polynuclear aromatic compounds

1988 • 56 citations

Biochemistry: G-protein control of inositol phosphate hydrolysis

1986 • 55 citations

DNA synthesis is blocked by cigarette tar-induced DNA single-strand breaks

1987 • 54 citations

Deficiency of DNA ligase activity in Fanconi's anemia

1978 • 51 citations

Tumor promoters and cocarcinogens in tobacco carcinogenesis.

1983 • 50 citations

Acute effects of 12-Otetradecanoylphorbol-13-acetate, teleocidin B, or 2,3,7,8-tetrachlorodibenzo-p-dioxin on cultured normal human bronchial epithelial cells

1984 • 50 citations

Banbury Report. 3. A safe cigarette?

1981 • 50 citations

Lung carcinoma induction in BD rats after a single intratracheal instillation of an arsenic‐containing pesticide mixture formerly used in vineyards

1979 • 49 citations

Mouse skin: a useful model system for studying the mechanism of chemical carcinogenesis.

1982 • 49 citations

Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes.

1989 • 47 citations

Asbestos-Associated Chromosomal Changes in Human Mesothelial Cells

1985 • 45 citations

Respiratory tract tumors in hamsters induced by benzo(a)pyrene and 210Po alpha-radiation.

1974 • 43 citations

The less harmful cigarette

1980 • 42 citations

Examination of the Role of Cigarette Smoke in Lung Carcinogenesis Using Multistage Models1

1988 • 42 citations

The cocarcinogenic activity of cigarette tobacco tar.

1958 • 41 citations

Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro.

1987 • 40 citations

N-acetylcysteine protection against the toxicity of cigarette smoke and cigarette smoke condensates in various tissues and cells in vitro.

1985 • 39 citations

Purification and Properties of a Mouse‐Cell DNA‐Repair Endonuclease, which Recognizes Lesions in DNA Induced by Ultraviolet Light, Depurination, γ‐Rays, and OsO₄ Treatment

1980 • 39 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein

1988 • 39 citations

Benzo(a)pyrene diolepoxide-DNA adducts detected by synchronous fluorescence spectrophotometry.

1985 • 39 citations

Endogenous formation of N-nitroso compounds: a current perspective.

1987 • 38 citations

The Pathologic Effects of Smoking Tobacco on the Trachea and Bronchial Mucosa

1960 • 34 citations

Papillomavirus Infections and Cancer

1987 • 34 citations

Reduced, radical, and excited state oxygen in leukocyte microbicidal activity.

1979 • 30 citations

Recombinant DNA applications to human disease

1983 • 28 citations

Induction of in vitro tumoricidal activity in alveolar macrophages and monocytes from patients with lung cancer

1989 • 24 citations

The Stratton Lecture. Hemolytic anemia and inborn errors of metabolism

1979 • 24 citations

Biochemical and molecular epidemiology of human cancer risk.

1985 • 22 citations

Oncogenes of DNA tumor viruses.

1988 • 21 citations

The Stratton Lecture. Hemolytic anemia and inborn errors of metabolism

1979 • 20 citations

Effects of serum, transforming growth factor type beta, or 12-O-tetradecanoyl-phorbol-13-acetate on ionized cytosolic calcium concentration in normal and transformed human bronchial epithelial cells.

1989 • 20 citations

Molecular associations and conceptual connections

1988 • 17 citations

EPIDEMIOLOGY OF CANCER: CURRENT PERSPECTIVES

1976 • 17 citations

Epstein-Barr virus as the cause of a human cancer

1978 • 16 citations

Biopsy Measurement of DNA Damage and Repair in Vivo: Single-Strand Breaks, Alkali-Labile Bonds, and Endonuclease-Sensitive Sites

1982 • 14 citations

Composition Studies on Tobacco. XLI. Carcinogenesis Assay of Subtractions of the Neutral Fraction of Cigarette Smoke Condensate<xref ref-type="fn" rid="FN2">2</xref>

1970 • 13 citations

Endogenous formation of N-nitroso compounds: a current perspective.

1987 • 11 citations

Constitutive expression of multiple messenger rna forms of the c jun oncogene in human lung cancer cell lines

1988 • 11 citations

The Pathologist and the Environment

1986 • 9 citations

Normal human bronchial epithelial cells do not show an adaptive response after treatment with N-methyl-N′-nitro-N-nitrosoguanidine

1985 • 8 citations

Introduction to neoplasia and antineoplastic chemotherapy

1980 • 2 citations

Nickel and nickel compounds

2023 • 1 citations