Calcineurin Inhibitor Nephrotoxicity

Case 39-2000

2000 • 3,891 citations

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

1990 • 3,809 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

The Banff 97 working classification of renal allograft pathology

1999 • 3,028 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity

2006 • 2,347 citations

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 • 2,120 citations

Chronic Renal Failure after Transplantation of a Nonrenal Organ

2003 • 2,101 citations

The Natural History of Chronic Allograft Nephropathy

2003 • 1,899 citations

Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions

2008 • 1,828 citations

Reduced Exposure to Calcineurin Inhibitors in Renal Transplantation

2007 • 1,692 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

NFAT proteins: key regulators of T-cell development and function

2005 • 1,434 citations

International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology

1993 • 1,431 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Cyclosporine-Associated Chronic Nephropathy

1984 • 1,174 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

CYCLOSPORIN A INITIALLY AS THE ONLY IMMUNOSUPPRESSANT IN 34 RECIPIENTS OF CADAVERIC ORGANS: 32 KIDNEYS, 2 PANCREASES, AND 2 LIVERS

1979 • 1,078 citations

Banff ’05 Meeting Report: Differential Diagnosis of Chronic Allograft Injury and Elimination of Chronic Allograft Nephropathy (’CAN’)

2007 • 1,073 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Antibody-Mediated Rejection Criteria - an Addition to the Banff ’97 Classification of Renal Allograft Rejection

2003 • 1,049 citations

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

1989 • 1,043 citations

Epithelial to Mesenchymal Transition in Renal Fibrogenesis

2004 • 1,036 citations

CYCLOSPORIN A IN PATIENTS RECEIVING RENAL ALLOGRAFTS FROM CADAVER DONORS

1978 • 1,010 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

2000 • 922 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Costimulation Blockade with Belatacept in Renal Transplantation

2005 • 833 citations

Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation

2004 • 828 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

2003 • 646 citations

Morphology, physiology, and molecular biology of renin secretion

1990 • 610 citations

GYNAECOLOGISTS' ATTITUDES TO ABORTION

1989 • 605 citations

Results of an International, Randomized Trial Comparing Glucose Metabolism Disorders and Outcome with Cyclosporine Versus Tacrolimus

2007 • 589 citations

Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data

2005 • 563 citations

Clinical Pharmacokinetics of Cyclosporin

1986 • 488 citations

Calcineurin Inhibitor Nephrotoxicity: Longitudinal Assessment by Protocol Histology

2004 • 486 citations

Long-Term Outcome of Renal Transplantation from Older Donors

2006 • 479 citations

Renin-Angiotensin-Aldosterone System and Progression of Renal Disease

2006 • 451 citations

Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy

1996 • 443 citations

Rethinking Chronic Allograft Nephropathy

1999 • 443 citations

The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

2004 • 434 citations

Effect of cyclosporine administration on renal hemodynamics in conscious rats

1985 • 416 citations

Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

2001 • 412 citations

Risk Factors for Cyclosporine-Induced Nephropathy in Patients with Autoimmune Diseases

1992 • 409 citations

A Meta-Analysis of Immunosuppression Withdrawal Trials in Renal Transplantation

2000 • 391 citations

HISTOPATHOLOGIC FINDINGS FROM 2-YEAR PROTOCOL BIOPSIES FROM A U.S. MULTICENTER KIDNEY TRANSPLANT TRIAL COMPARING TACROLIMUS VERSUS CYCLOSPORINE

1998 • 371 citations

Role of endothelin in cyclosporine-induced glomerular dysfunction

1990 • 368 citations

Renal Histopathologic Alterations in Patients Treated with Cyclosporine for Uveitis

1986 • 350 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Cyclosporin Clinical Pharmacokinetics

1993 • 338 citations

South Africa

1985 • 333 citations

Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects

1999 • 323 citations

Tacrolimus with Mycophenolate Mofetil (MMF) or Sirolimus vs. Cyclosporine with MMF in Cardiac Transplant Patients: 1-Year Report

2006 • 321 citations

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and p-glycoprotein correlate with dose requirement

2002 • 318 citations

THE TEMPORAL PROFILE OF CALCINEURIN INHIBITION BY CYCLOSPORINE IN VIVO1

1999 • 317 citations

Calcineurin inhibitor‐sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity

2007 • 310 citations

Up-regulation of Multidrug Resistance P-glycoprotein via Nuclear Factor-κB Activation Protects Kidney Proximal Tubule Cells from Cadmium- and Reactive Oxygen Species-induced Apoptosis

2000 • 305 citations

Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus

2002 • 303 citations

CYCLOSPORINE-INDUCED ACUTE RENAL DYSFUNCTION IN THE RAT EVIDENCE OF ARTERIOLAR VASOCONSTRICTION WITH PRESERVATION OF TUBULAR FUNCTION

1987 • 303 citations

RELATIONSHIP OF FK506 WHOLE BLOOD CONCENTRATIONS AND EFFICACY AND TOXICITY AFTER LIVER AND KIDNEY TRANSPLANTATION

1996 • 300 citations

Renal injury due to renin–angiotensin–aldosterone system activation of the transforming growth factor-β pathway

2006 • 285 citations

Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies

2001 • 284 citations

Association of the Multidrug Resistance-1 Gene Single-Nucleotide Polymorphisms with the Tacrolimus Dose Requirements in Renal Transplant Recipients

2003 • 281 citations

International variation in the interpretation of renal transplant biopsies: Report of the CERTPAP Project11A complete listing of the participants who all contributed equally to the work of the CERTPAP Project includes Peter N. Furness (Leicester, UK); Nicholas Taub (Leicester, United Kingdom); Karel J.M. Assmann (Nijmegen, The Netherlands); Giovanni Banfi (Milan, Italy); John N. Botelis (Athens, Greece); Marta Carrera (Barcelona, Spain); Jean-Pierre Cosyns (Brussels, Belgium); Anthony M. Dorman…

2001 • 280 citations

Kidney and Pancreas Transplantation in the United States, 1996–2005

2007 • 271 citations

The side-effects of ciclosporine-A and tacrolimus.

1998 • 270 citations

Cyclosporine Sparing with Mycophenolate Mofetil, Daclizumab and Corticosteroids in Renal Allograft Recipients: The CAESAR Study

2007 • 264 citations

Acute renal failure with selective medullary injury in the rat.

1988 • 262 citations

EFFECT OFCYP3A5POLYMORPHISM ON TACROLIMUS METABOLIC CLEARANCE IN VITRO

2006 • 260 citations

Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial

2002 • 257 citations

NEPHROTOXICITY OF CYCLOSPORIN A IN LIVER AND KIDNEY TRANSPLANT PATIENTS

1981 • 252 citations

Pathogenesis of cyclosporine nephropathy

1995 • 250 citations

Influence of CYP3A5 and MDR1 (ABCB1) Polymorphisms on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients

2004 • 248 citations

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

1991 • 248 citations

Cyclosporine-Induced Hyperuricemia and Gout

1989 • 247 citations

Silent SNPs: Impact on Gene Function and Phenotype

2007 • 241 citations

Kidney Transplantation Under FK 506

1990 • 236 citations

Juxtaglomerular cell complex in the regulation of renal salt excretion

1998 • 230 citations

Clinically Significant Drug Interactions with Cyclosporin

1996 • 229 citations

RAPAMYCIN: CLINICAL RESULTS AND FUTURE OPPORTUNITIES1

2001 • 224 citations

Pharmacokinetic Interactions Augment Toxicities of Sirolimus/Cyclosporine Combinations

2001 • 222 citations

AN OPEN-LABEL, CONCENTRATION-RANGING TRIAL OF FK506 IN PRIMARY KIDNEY TRANSPLANTATION

1996 • 218 citations

Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion

1993 • 217 citations

Calcineurin

1999 • 217 citations

Three‐Year Efficacy and Safety Results from a Study of Everolimus Versus Mycophenolate Mofetil in de novo Renal Transplant Patients

2005 • 217 citations

The Histopathological Changes Associated with Allograft Rejection and Drug Toxicity in Renal Transplant Recipients Maintained on FK506

1993 • 216 citations

ABCB1 Genotype of the Donor but Not of the Recipient Is a Major Risk Factor for Cyclosporine-Related Nephrotoxicity after Renal Transplantation

2005 • 213 citations

Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity

1987 • 210 citations

Angiotensin II blockade decreases TGF-β1 and matrix proteins in cyclosporine nephropathy

1997 • 207 citations

International Variation in Histologic Grading Is Large, and Persistent Feedback Does Not Improve Reproducibility

2003 • 206 citations

CYP3A5 and CYP3A4 but not MDR1 Single-nucleotide Polymorphisms Determine Long-term Tacrolimus Disposition and Drug-related Nephrotoxicity in Renal Recipients

2007 • 205 citations

Tacrolimus Pharmacogenetics: The CYP3A5*1 Allele Predicts Low Dose-Normalized Tacrolimus Blood Concentrations in Whites and South Asians

2005 • 204 citations

Dephosphorylation of Endothelial Nitric-oxide Synthase by Vascular Endothelial Growth Factor

2002 • 190 citations

Randomized trial of tacrolimus in combination with sirolimus or mycophenolate mofetil in kidney transplantation: results at 6 months1

2003 • 189 citations

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation

2004 • 187 citations

Computerized Image Analysis of Sirius Red–Stained Renal Allograft Biopsies as a Surrogate Marker to Predict Long-Term Allograft Function

2003 • 187 citations

Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation

2007 • 183 citations

Immunophilins in the Nervous System

1998 • 181 citations

Renal Transplant-Associated Hyperuricemia and Gout

2000 • 181 citations

Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats.

1985 • 179 citations

Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine

1998 • 178 citations

Endothelin mediates the renal vasoconstriction induced by cyclosporine in the rat.

1990 • 176 citations

Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity

1995 • 174 citations

Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the and genes

2004 • 172 citations

Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis

1998 • 170 citations

Lipid peroxidation accompanies cyclosporine nephrotoxicity: Effects of vitamin E

1995 • 166 citations

PEAK-FLOW METER VERSUS PEAK-FLOW GAUGE

1974 • 165 citations

AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients

2005 • 165 citations

Ketoconazole to Reduce the Need for Cyclosporine after Cardiac Transplantation

1995 • 164 citations

Apoptosis and necrosis: Mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line

1998 • 161 citations

CHRONIC INJURY OF HUMAN RENAL MICROVESSELS WITH LOW-DOSE CYCLOSPORINE THERAPY

1988 • 160 citations

The impact of aging on kidney repair

2008 • 158 citations

Cyclosporine A-Induced Renal Fibrosis

2005 • 153 citations

Losartan decreases plasma levels of TGF-β1 in transplant patients with chronic allograft nephropathy

1999 • 152 citations

Ciclosporin in psoriasis clinical practice: an international consensus statement

2004 • 152 citations

N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats

1999 • 149 citations

Expression of TGF-β and fibrogenic genes in transplant recipients with tacrolimus and cyclosporine nephrotoxicity

2002 • 149 citations

Prevention of Acute Graft Rejection by the Prostaglandin E₁Analogue Misoprostol in Renal-Transplant Recipients Treated with Cyclosporine and Prednisone

1990 • 147 citations

INTERSTITIAL FIBROSIS IN RENAL ALLOGRAFTS AFTER 12 TO 46 MONTHS OF CYCLOSPORIN TREATMENT: BENEFICIAL EFFECT OF LOW DOSES IN EARLY POST-TRANSPLANTATION PERIOD

1984 • 147 citations

Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects

2002 • 147 citations

Evaluation of renal function in liver transplant recipients receiving daclizumab (Zenapax), mycophenolate mofetil, and a delayed, low-dose tacrolimus regimen vs. a standard-dose tacrolimus and mycophenolate mofetil regimen: A multicenter randomized clinical trial

2005 • 145 citations

Cyclosporine Microemulsion (Neoral®) Absorption Profiling and Sparse-sample Predictors During the First 3 Months after Renal Transplantation

2002 • 144 citations

Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity

2003 • 144 citations

Global glomerular sclerosis and glomerular arteriolar hyalinosis in insulin dependent diabetes

1991 • 144 citations

Molecular Determinants of Magnesium Homeostasis

2008 • 141 citations

IMMUNOLOGICAL AND PHARMACOLOGICAL MONITORING IN THE CLINICAL USE OF CYCLOSPORIN A

1981 • 141 citations

Increased Expression of Senescence-Associated Cell Cycle Inhibitor p16 in Deteriorating Renal Transplants and Diseased Native Kidney

2005 • 138 citations

Dissociation of glomerular filtration rate from tubulointerstitial fibrosis in experimental chronic cyclosporine nephropathy

1993 • 136 citations

ONE-YEAR FOLLOW-UP OF AN OPEN-LABEL TRIAL OF FK506 FOR PRIMARY KIDNEY TRANSPLANTATION1

1996 • 135 citations

Early Epithelial Phenotypic Changes Predict Graft Fibrosis

2008 • 135 citations

Bartter’s and Gitelman’s Syndromes: From Gene to Clinic

2004 • 134 citations

SYNERGISTIC EFFECTS OF CYCLOSPORINE AND RAPAMYCIN IN A CHRONIC NEPHROTOXICITY MODEL1

1996 • 133 citations

Predictors and Evolution of Renal Function during 9 Years Following Heart Transplantation

2000 • 131 citations

Minimizing Immunosuppression, an Alternative Approach to Reducing Side Effects

2008 • 130 citations

New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone

2007 • 130 citations

Cyclosporine A induces senescence in renal tubular epithelial cells

2007 • 128 citations

Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts

2007 • 128 citations

Therapeutic Role of TGF-β–Neutralizing Antibody in Mouse Cyclosporin A Nephropathy

2003 • 127 citations

SUSTAINED IMPROVEMENT OF RENAL GRAFT FUNCTION FOR TWO YEARS IN HYPERTENSIVE RENAL TRANSPLANT RECIPIENTS TREATED WITH NIFEDIPINE AS COMPARED TO LISINOPRIL1

2001 • 125 citations

Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis

1999 • 125 citations

Reliability of chronic allograft nephropathy diagnosis in sequential protocol biopsies

2002 • 122 citations

Early and Late Forms of Cyclosporine Nephrotoxicity: Studies in Cardiac Transplant Recipients

1987 • 121 citations

Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+ Channels in Arterial Smooth Muscle and Contributes to Hypertension

2006 • 121 citations

Effect of anti-transforming growth factor-βbgr; antibodies in cyclosporine-induced renal dysfunction

2001 • 121 citations

Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy

2004 • 120 citations

Morphological patterns in cyclosporine-treated renal transplant recipients.

1985 • 119 citations

Acute renal failure associated with immunoglobulin therapy

1995 • 119 citations

HIV-associated nephropathy in African Americans11The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. The publisher or recipient acknowledges right of the U.S. Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article.

2003 • 117 citations

Generation and Evolution of Atubular Glomeruli in the Progression of Renal Disorders

2008 • 117 citations

REPRODUCIBILITY OF THE BANFF CLASSIFICATION OF RENAL ALLOGRAFT PATHOLOGY

1995 • 117 citations

Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea

2005 • 117 citations

Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine–sirolimus interaction

2006 • 114 citations

Vascular mechanisms of cyclosporin-induced hypertension in the rat.

1994 • 113 citations

The Clinical Benefits of Cyclosporine C2-Level Monitoring: A Systematic Review

2007 • 112 citations

Long-Term Graft Survival with Neoral and Tacrolimus

2003 • 112 citations

Renal insufficiency after heart transplantation: a case-control study

1998 • 111 citations

Cyclosporine produces endothelial dysfunction by increased production of superoxide.

1994 • 111 citations

Time-Related Clinical Determinants of Long-Term Tacrolimus Pharmacokinetics in Combination Therapy with Mycophenolic Acid and Corticosteroids

2004 • 111 citations

Converting-enzyme inhibitor versus calcium antagonist in cyclosporine-treated renal transplants

1993 • 110 citations

NFATc3 Regulates Kv2.1 Expression in Arterial Smooth Muscle

2004 • 110 citations

Cyclosporine A induced arteriolopathy in a rat model of chronic cyclosporine nephropathy

1995 • 109 citations

Expression of MDR1 (Multidrug Resistance) Gene and Its Protein in Normal Human Kidney

1997 • 108 citations

Effects of Losartan and Amlodipine on Intrarenal Hemodynamics and TGF-β1 Plasma Levels in a Crossover Trial in Renal Transplant Recipients

2001 • 107 citations

The Aggravating Mechanisms of Aldosterone on Kidney Fibrosis

2008 • 107 citations

Cyclosporine A enhances renin secretion and production in isolated juxtaglomerular cells

1988 • 105 citations

Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients

2008 • 105 citations

Expression and Function of the Nuclear Factor of Activated T Cells in Colon Carcinoma Cells

2005 • 104 citations

Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506.

1995 • 103 citations

Tacrolimus versus ciclosporin immunosuppression: long-term outcome in renal transplantation

2003 • 103 citations

A CONTROLLED TRIAL OF CYCLOSPORINE IN RENAL TRANSPLANTATION WITH CONVERSION TO AZATHIOPRINE AND PREDNISOLONE AFTER THREE MONTHS

1983 • 103 citations

Time Course of the Decline in Renal Function in Cyclosporine-Treated Heart Transplant Recipients

1994 • 102 citations

Risk Factors for Early Epithelial to Mesenchymal Transition in Renal Grafts

2006 • 102 citations

A Randomized Long-Term Trial of Tacrolimus/Sirolimus versus Tacrolimums/Mycophenolate versus Cyclosporine/Sirolimus in Renal Transplantation: Three-Year Analysis

2006 • 101 citations

Stimulation of transforming growth factor‐β₁ transcription by cyclosporine

1995 • 101 citations

Nephron segment-specific inhibition of Na+/K+-ATPase activity by cyclosporin A

1993 • 100 citations

DE NOVO COLLAPSING GLOMERULOPATHY IN RENAL ALLOGRAFTS1

1998 • 99 citations

Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling

2005 • 95 citations

Cytochrome P450 3A Polymorphisms and Immunosuppressive Drugs: An Update

2007 • 93 citations

STUDIES ON THE IMMUNOSUPPRESSIVE PROPERTIES OF CYCLOSPORIN A IN RATS RECEIVING RENAL ALLOGRAFTS

1980 • 93 citations

The Pharmacogenetics of Calcineurin Inhibitors: One Step Closer Toward Individualized Immunosuppression?

2005 • 93 citations

Urinary endothelin and renal vasoconstriction with cyclosporine or FK506 after liver transplantation

1995 • 92 citations

Gemcitabine-associated hemolytic-uremic syndrome

2002 • 92 citations

Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients

2001 • 92 citations

Risk factors for renal glomerular and vascular changes in an autopsy-based population survey: The Hisayama Study

2003 • 89 citations

Calcium Channel Blockade and Preservation of Renal Graft Function in Cyclosporine-Treated Recipients: A Prospective Randomized Placebo-Controlled 2-Year Study

2004 • 89 citations

A Comparison of Tacrolimus and Cyclosporine in Liver Transplantation: Effects on Renal Function and Cardiovascular Risk Status

2005 • 89 citations

CYCLOSPORINE PLASMA LEVELS IN RENAL TRANSPLANT PATIENTS

1985 • 88 citations

Low Intraindividual Variability of Cyclosporin A Exposure Reduces Chronic Rejection Incidence and Health Care Costs

2000 • 88 citations

COMPUTERIZED HISTOMORPHOMETRIC ASSESSMENT OF PROTOCOL RENAL TRANSPLANT BIOPSY SPECIMENS FOR SURROGATE MARKERS OF CHRONIC REJECTION

1999 • 87 citations

Efficacy of ISA247 in plaque psoriasis: a randomised, multicentre, double-blind, placebo-controlled phase III study

2008 • 87 citations

No Difference in Degree of Interstitial Sirius Red–Stained Area in Serial Biopsies from Area under Concentration-over-Time Curves–Guided Cyclosporine versus Tacrolimus-Treated Renal Transplant Recipients at One Year

2005 • 86 citations

Potentiation by Nitric Oxide of Cyclosporin A and FK506-Induced Apoptosis in Renal Proximal Tubule Cells

2000 • 86 citations

Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings

2000 • 85 citations

Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors

2003 • 85 citations

Hypertensive nephrosclerosis: pathogenesis and prevalence

1999 • 85 citations

Effect of nitrendipine on renal function in renal-transplant patients treated with cyclosporin: a randomised trial

1999 • 85 citations

Cyclosporin A treatment induces overexpression of P-glycoprotein in the kidney and other tissues

1996 • 84 citations

Tacrolimus Exposure and Evolution of Renal Allograft Histology in the First Year After Transplantation

2007 • 84 citations

Morphology of cyclosporine nephrotoxicity in the rat.

1986 • 79 citations

Expression of Apoptosis-related Genes in Chronic Cyclosporine Nephrotoxicity in Mice

2002 • 79 citations

Cyclosporin A Inhibits Flow-mediated Activation of Endothelial Nitric-oxide Synthase by Altering Cholesterol Content in Caveolae

2004 • 79 citations

Contribution of tubular injury to loss of remnant kidney function

1998 • 78 citations

ORAL CYCLOSPORINE BUT NOT TACROLIMUS REDUCES RENAL TRANSPLANT BLOOD FLOW

2004 • 77 citations

Blood Vessels and the Aging Kidney

2005 • 77 citations

The Role of Therapeutic Drug Monitoring in Individualizing Immunosuppressive Drug Therapy: Recent Developments

2006 • 76 citations

CYCLOSPORINE-INDUCED INTERSTITIAL FIBROSIS AND ARTERIOLAR TGF-?? EXPRESSION WITH PRESERVED RENAL BLOOD FLOW

1999 • 76 citations

MDR1 haplotypes derived from exons 21 and 26 do not affect the steady‐state pharmacokinetics of tacrolimus in renal transplant patients

2004 • 75 citations

Interaction of cyclosporine A and nonsteroidal anti-inflammatory drugs on renal function in patients with rheumatoid arthritis

1992 • 74 citations

Cytochrome P450 3A5 expression in the kidneys of patients with calcineurin inhibitor nephrotoxicity

2007 • 73 citations

Hyponatraemia and hyperkalaemia are more frequent in renal transplant recipients treated with tacrolimus than with cyclosporin. Further evidence for differences between cyclosporin and tacrolimus nephrotoxicities

2004 • 73 citations

Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors

2001 • 73 citations

Reproducibility of the Banff schema in reporting protocol biopsies of stable renal allografts

2002 • 73 citations

The Evolution of Nonimmune Histological Injury and Its Clinical Relevance in Adult-Sized Kidney Grafts in Pediatric Recipients

2007 • 72 citations

Molecular Comparison of Calcineurin Inhibitor–Induced Fibrogenic Responses in Protocol Renal Transplant Biopsies

2006 • 71 citations

Evolution and Pathophysiology of Renal-Transplant Glomerulosclerosis

2004 • 71 citations

Cyclosporine and the renin-angiotensin axis

1997 • 71 citations

Tissue Distribution of Calcineurin and its Sensitivity to Inhibition by Cyclosporine

2001 • 70 citations

A₁adenosine receptor knockout mice are protected against acute radiocontrast nephropathy in vivo

2006 • 70 citations

Interaction of Cyclosporine A and the Renin-Angiotensin System New Perspectives

2002 • 69 citations

Cyclosporine A Suppresses Cyclooxygenase-2 Expression in the Rat Kidney

2002 • 69 citations

Use of Neoral C2 monitoring: a European consensus

2005 • 68 citations

Cyclosporine nephrotoxicity: how does it affect renal allograft function and transplant morphology?

2004 • 68 citations

Relative Tissue Distributions of Cyclosporine and Sirolimus After Concomitant Peroral Administration to the Rat: Evidence for Pharmacokinetic Interactions

1998 • 68 citations

Renal failure after clinical heart transplantation is associated with the TGF-β1 codon 10 gene polymorphism

2000 • 67 citations

Endothelin-1 Induces Cyclooxygenase-2 Expression Via Nuclear Factor of Activated T-Cell Transcription Factor in Glomerular Mesangial Cells

2001 • 67 citations

Cyclosporin exerts a direct fibrogenic effect on human tubulointerstitial cells: roles of insulin-like growth factor I, transforming growth factor beta1, and platelet-derived growth factor.

1999 • 67 citations

Evidence that the inhibition of Na+/K+-ATPase activity by FK506 involves calcineurin

1994 • 66 citations

Distal tubular acidosis induced by FK506

1998 • 66 citations

Apoptosis and adaptive responses to oxidative stress in human endothelial cells exposed to cyclosporin A correlate with BCL‐2 expression levels

2001 • 66 citations

Immunophilin Regulation of Neurotransmitter Release

1996 • 65 citations

Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension

2000 • 65 citations

Cyclosporin A produces distal renal tubular acidosis by blocking peptidyl prolyl cis-trans isomerase activity of cyclophilin

2004 • 65 citations

Focal segmental glomerulosclerosis in renal allografts with chronic nephropathy: Implications for graft survival

1999 • 65 citations

A possible role for nitric oxide in modulating the functional cyclosporine toxicity by arginine

1995 • 63 citations

De novo thrombotic microangiopathy. An underrated complication of renal transplantation

2007 • 63 citations

Differential Effect of Diarrhea on FK506 Versus Cyclosporine A Trough Levels and Resultant Prevention of Allograft Rejection in Renal Transplant Recipients

2002 • 62 citations

Immunosuppressive drug monitoring - what to use in clinical practice today to improve renal graft outcome

2005 • 62 citations

Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia–reperfusion injury

2000 • 62 citations

p-Glycoprotein-mediated transport of a fluorescent rapamycin derivative in renal proximal tubule.

1997 • 61 citations

Predictors of Chronic Kidney Disease in Long-Term Survivors of Lung and Heart-Lung Transplantation

2006 • 61 citations

Muscle function during jumping in frogs. II. Mechanical properties of muscle: implications for system design

1996 • 61 citations

Studies on morphological outcome of cyclosporine-associated arteriolopathy after discontinuation of cyclosporine in renal allografts.

1992 • 61 citations

T cell–directed therapies: lessons learned and future prospects

2006 • 61 citations

Reproducibility Studies on Arteriolar Hyaline Thickening Scoring in Calcineurin Inhibitor-Treated Renal Allograft Recipients

2006 • 60 citations

Low serum magnesium is associated with decreased graft survival in patients with chronic cyclosporin nephrotoxicity

2005 • 59 citations

A Novel, Semiquantitative, Clinically Correlated Calcineurin Inhibitor Toxicity Score for Renal Allograft Biopsies

2006 • 58 citations

Down-regulation of the intrarenal renin-angiotensin system in the aging rat.

1995 • 58 citations

ENHANCEMENT OF FK506 NEPHROTOXICITY BY SODIUM DEPLETION IN AN EXPERIMENTAL RAT MODEL

1994 • 57 citations

Formation of peroxynitrite in vascular endothelial cells exposed to cyclosporine A

2001 • 56 citations

Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity

2005 • 56 citations

ROLE OF HYPOMAGNESEMIA IN CHRONIC CYCLOSPORINE NEPHROPATHY1

2002 • 56 citations

Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients1

2003 • 56 citations

Stimulatory effect of cyclosporine A on endothelin secretion by a cultured renal epithelial cell line, LLC-PK1 cells

1990 • 56 citations

Cyclooxygenase-2 Modulates Afferent Arteriolar Responses to Increases in Pressure

1999 • 55 citations

Drug interactions and consequences of sodium restriction

1997 • 55 citations

Conversion From Cyclosporine to Tacrolimus in Patients at Risk for Chronic Renal Allograft Failure: 60-Month Results of the CRAF Study

2008 • 55 citations

Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms

2008 • 54 citations

Response of human renal tubular cells to cyclosporine and sirolimus: A toxicogenomic study

2008 • 54 citations

The clinical significance of cyclosporine metabolites

1991 • 54 citations

Cyclosporin A stimulates transcription and procollagen secretion in tubulointerstitial fibroblasts and proximal tubular cells.

1990 • 54 citations

Acute Tubular Injury in Protocol Biopsies of Renal Grafts: Prevalence, Associated Factors and Effect on Long-Term Function

2008 • 54 citations

Cyclosporine-induced changes in glomerular filtration rate and urea excretion

1990 • 53 citations

Effect of CsA on the expression of renin and angiotensin type 1 receptor genes in the rat kidney

1993 • 53 citations

Calcineurin Inhibitor–Induced Nephrotoxicity and Renal Expression of P-glycoprotein

2005 • 51 citations

Dietary potassium and magnesium supplementation in cyclosporine-induced hypertension and nephrotoxicity

2000 • 51 citations

Influence of Ciclosporin A on Renal Tubular Function after Kidney Transplantation

1991 • 50 citations

Immunosuppressive activity of cyclosporine metabolites compared and characterized by mass spectroscopy and nuclear magnetic resonance.

1990 • 50 citations

Calcium Modulation of Vascular Smooth Muscle ATP-Sensitive K ⁺ Channels

2000 • 50 citations

Tacrolimus-associated hemolytic uremic syndrome: a case analysis.

2003 • 49 citations

EFFECTS OF THE PROSTAGLANDIN E1 ANALOG MISOPROSTOL ON CYCLOSPORINE NEPHROTOXICITY

1988 • 49 citations

Regional haemodynamic effects of cyclosporine A, tacrolimus and sirolimus in conscious rats

2004 • 49 citations

A RANDOMIZED CONTROLLED TRIAL OF VERAPAMIL ON CYCLOSPORINE NEPHROTOXICITY IN HEART AND LUNG TRANSPLANT RECIPIENTS1

1997 • 49 citations

Role of reactive oxygen formation in the cyclosporin-A-mediated impairment of renal functions.

1994 • 48 citations

Impact of the variability of cyclosporin A trough levels on long-term renal allograft function

2002 • 48 citations

Risk factors for long-term renal survival after renal transplantation

1998 • 47 citations

VITAMIN E INHIBITS RENAL mRNA EXPRESSION OF COX II, HO I, TGF??, AND OSTEOPONTIN IN THE RAT MODEL OF CYCLOSPORINE NEPHROTOXICITY

2001 • 47 citations

Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells

1999 • 47 citations

Role for TGF-β in Cyclosporine-Induced Modulation of Renal Epithelial Barrier Function

2007 • 45 citations

Relevance of IL10, TGFβ1, TNFα, and IL4Rα Gene Polymorphisms in Kidney Transplantation: A Collaborative Transplant Study Report

2004 • 45 citations

Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells

2005 • 45 citations

Role of Intrarenal Endothelin 1, Endothelin 3, and Angiotensin II Expression in Chronic Cyclosporin A Nephrotoxicity in Rats

2000 • 45 citations

Can Donor Implantation Renal Biopsy Predict Long-Term Renal Allograft Outcome?

2007 • 45 citations

Regulation of endothelial NO synthase expression by cyclosporin A in bovine aortic endothelial cells

1996 • 45 citations

Toxicity of Cyclosporine Metabolites

1990 • 44 citations

ANGIOTENSIN GENE POLYMORPHISM AS A DETERMINANT OF POSTTRANSPLANTATION RENAL DYSFUNCTION AND HYPERTENSION1,2

2001 • 44 citations

Ciclosporin metabolite pattern in blood and urine of liver graft recipients

1991 • 44 citations

Different renal toxicity profiles in the association of cyclosporine and tacrolimus with sirolimus in rats

2008 • 43 citations

Proximal Tubular Dysfunction is Associated with Chronic Allograft Nephropathy and Decreased Long-Term Renal-Graft Survival

2004 • 43 citations

Tacrolimus and sirolimus decrease oxidative phosphorylation of isolated rat kidney mitochondria

2003 • 43 citations

Antagonist capacities of nifedipine, captopril, phenoxybenzamine, prostacyclin and indomethacin on cyclosporin A induced impairment of rat renal function

1986 • 43 citations

Follow-up of Kidney Graft Recipients With Cyclosporine-Associated Hemolytic-Uremic Syndrome and Thrombotic Microangiopathy

2005 • 42 citations

Maturation of Dose-Corrected Tacrolimus Predose Trough Levels in Pediatric Kidney Allograft Recipients

2008 • 42 citations

Hyperchloremic metabolic acidosis with high serum potassium in renal transplant recipients: a cyclosporine A associated side effect.

1986 • 41 citations

Ketoconazole-Tacrolimus Coadministration in Kidney Transplant Recipients: Two-Year Results of a Prospective Randomized Study

2006 • 41 citations

Downregulation of Renal Sodium Transporters and Tonicity-Responsive Enhancer Binding Protein by Long-Term Treatment with Cyclosporin A

2007 • 41 citations

Switching from Cyclosporine to Tacrolimus in Patients with Chronic Transplant Dysfunction or Cyclosporine-Induced Adverse Events

2004 • 39 citations

The Impact of Transforming Growth Factor-β1 Gene Polymorphism on End-Stage Renal Failure After Heart Transplantation

2006 • 39 citations

A PROSPECTIVE, RANDOMIZED STUDY OF COADMINISTRATION OF KETOCONAZOLE AND CYCLOSPORINE A IN KIDNEY TRANSPLANT RECIPIENTS: TEN-YEAR FOLLOW-UP

2004 • 39 citations

Chronic cyclosporin A nephrotoxicity, P-glycoprotein overexpression, and relationships with intrarenal angiotensin II deposits.

1997 • 39 citations

Conversion to tacrolimus for the treatment of cyclosporine-associated nephrotoxicity in heart transplant recipients

2002 • 38 citations

PHARMACOKINETICS AND NEPHROTOXICITY OF CYCLOSPORINE IN RENAL TRANSPLANT RECIPIENTS

1985 • 38 citations

CsA LEVELS IN THE EARLY POSTTRANSPLANT PERIOD—PREDICTIVE OF CHRONIC REJECTION IN LIVER TRANSPLANTATION?

1995 • 38 citations

Combined Effects of Losartan and Pravastatin on Interstitial Inflammation and Fibrosis in Chronic Cyclosporine-Induced Nephropathy

2005 • 38 citations

Comparative Acute Nephrotoxicity of FK-506 and Ciclosporin in an Isolated in situ Autoperf used Rat Kidney Model

1997 • 37 citations

Distribution and Activity of Calcineurin in Rat Tissues

1995 • 37 citations

Cyclosporine Concentration Determinations for Monitoring and Pharmacokinetic Studies

1986 • 37 citations

Activation of transcription factors AP-1 and NF-κB in chronic cyclosporine A nephrotoxicity: role in beneficial effects of magnesium supplementation1

2003 • 36 citations

Prevention of Renal Dysfunction and Hypertension by Amlodipine After Heart Transplant

2007 • 36 citations

CORRELATION BETWEEN ANGIOTENSIN-CONVERTING ENZYME GENE INSERTION/DELETION POLYMORPHISM AND KIDNEY GRAFT LONG-TERM OUTCOME IN PEDIATRIC RECIPIENTS

1999 • 36 citations

Effect of 6 weeks of vitamin E administration on renal haemodynamic alterations following a single dose of neoral in healthy volunteers

2001 • 35 citations

Experimental nephrotoxicity, hepatotoxicity and pharmacokinetics of cyclosporin G versus cyclosporin A

1994 • 34 citations

No Association Between Single Nucleotide Polymorphisms and the Development of Nephrotoxicity After Orthotopic Heart Transplantation

2008 • 34 citations

Ciclosporin reduces paracellin-1 expression and magnesium transport in thick ascending limb cells

2007 • 33 citations

Cyclosporine, but not FK506, selectively induces renal and coronary artery smooth muscle contraction

1998 • 33 citations

Clinical validation and reproducibility of the Banff schema for renal allograft pathology.

1995 • 32 citations

POSTTRANSPLANT HEMOLYTIC UREMIC SYNDROME IN ADULT RETRANSPLANTED KIDNEY GRAFT RECIPIENTS: ADVANTAGE OF FK506 THERAPY?

1998 • 32 citations

Cyclosporine A and NAC on the inducible nitric oxide synthase expression and nitric oxide synthesis in rat renal artery cultured cells

2005 • 32 citations

Studies on the effects of cyclosporin A upon renal allograft rejection in the dog.

1980 • 31 citations

Different Effects of Cyclosporine A and FK506 on Potassium Transport Systems in MDCK Cells

2001 • 30 citations

Angiotensin-converting enzyme genotype and renal allograft survival.

1997 • 30 citations

Cyclosporine A attenuates the natriuretic action of loop diuretics by inhibition of renal COX-2 expression

2004 • 30 citations

PGE2 reduces nephrotoxicity and immunosuppression of cyclosporine in rats.

1986 • 30 citations

Role of cytokine gene polymorphisms in acute rejection and renal impairment after liver transplantation

2001 • 30 citations

Cyclosporin A tubular effects contribute to nephrotoxicity: role for Ca2+ and Mg2+ ions

2003 • 30 citations

Long-term protective effect of a calcium antagonist on renal function in hypertensive renal transplant patients on cyclosporine therapy: a 5-year prospective randomized study.

1994 • 29 citations

Factors influencing glomerular filtration rate in renal transplantation after cyclosporine withdrawal using sirolimus‐based therapy: a multivariate analysis of results at five years¹

2007 • 29 citations

Sympathetic nerve activity in renal transplant patients before and after withdrawal of cyclosporine

2006 • 28 citations

THE ROLE OF RENAL SYMPATHETIC NERVES IN EXPERIMENTAL CHRONIC CYCLOSPORINE NEPHROPATHY

2000 • 28 citations

Effect of cyclosporine A on Na+/K(+)-ATPase, Na+/K+/2Cl- cotransporter, and H+/K(+)-ATPase in MDCK cells and two subtypes, C7 and C11.

1998 • 27 citations

Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors

2001 • 27 citations

Effects of ACE Inhibition on Cyclosporine A-Induced Hypertension and Nephrotoxicity in Spontaneously Hypertensive Rats on a High-sodium Diet

1999 • 26 citations

Immunohistochemical Analysis of Renin Activity in Chronic Cyclosporine Nephropathy in Childhood Nephrotic Syndrome

2000 • 26 citations

Vascular changes in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet.

2001 • 26 citations

Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations

1991 • 25 citations

De novo focal glomerulosclerosis after kidney transplantation

1988 • 25 citations

REVERSIBLE CYCLOSPORINE ARTERIOLOPATHY

1992 • 24 citations

Tacrolimus and Nonsteroidal Anti-Inflammatory Drugs: An Association to Be Avoided

2005 • 24 citations

Indomethacin and cyclosporin together produce marked renal vasoconstriction in humans

1994 • 23 citations

Absorption, Distribution, Metabolism and Excretion of Tacrolimus(FK506) in the Rat.

1998 • 23 citations

Blockade of Angiotensin II with Losartan Attenuates Transforming Growth Factor-β1 Inducible Gene-h3 (βig-h3) Expression in a Model of Chronic Cyclosporine Nephrotoxicity

2005 • 22 citations

Impact of TGFβ1 gene polymorphisms on late renal function in pediatric heart transplantation

2004 • 22 citations

Diclofenac combined with cyclosporine in treatment refractory rheumatoid arthritis: longitudinal safety assessment and evidence of a pharmacokinetic/dynamic interaction.

1996 • 22 citations

L-arginine supplementation in young renal allograft recipients with chronic transplant dysfunction.

2001 • 22 citations

EFFECT OF CYCLOSPORIN A ON NITRIC OXIDE PRODUCTION IN CULTURED LLC-PK₁CELLS

2001 • 21 citations

Sublethal heat shock and cyclosporine exposure produce tolerance against subsequent cyclosporine toxicity

1996 • 21 citations

Effect of molsidomine and l-arginine in cyclosporine nephrotoxicity: role of nitric oxide

2004 • 20 citations

Differential interaction of human renal P-glycoprotein with various metabolites and analogues of cyclosporin A

1995 • 20 citations

TIME‐DEPENDENT CYCLOSPORINE A‐INDUCED NEPHROTOXICITY IN RATS

1998 • 19 citations

Case 12-2007

2007 • 19 citations

Overview of FK506 in transplantation.

1990 • 19 citations

Isometric Tubular Epithelial Vacuolization in Renal Allograft Biopsy Specimens of Patients Receiving Low-Dose Intravenous Immunoglobulin for a Positive Crossmatch

2004 • 19 citations

Cyclosporin exposure correlates with 1 year graft function and histological damage in renal transplanted patients

2004 • 19 citations

Cyclosporin A Induces an Atypical Heat Shock Response

2000 • 18 citations

Light microscopic and electron microscopic features of cyclosporine nephrotoxicity in rats

1995 • 18 citations

Cyclosporin-A-induced effects on the free Ca2+ concentration in LLC-PK1-cells and their mechanisms

2000 • 18 citations

Antihypertensive treatment in renal transplant patients--is there a role for ACE inhibitors?

2001 • 17 citations

Distribution of heat shock proteins in kidneys of rats after immunosuppressive treatment with cyclosporine A

2001 • 16 citations

CLINICAL SIGNIFICANCE OF RENAL BIOPSIES SHOWING CONCURRENT ACUTE REJECTION AND TACROLIMUS-ASSOCIATED TUBULAR VACUOLIZATION1

1999 • 16 citations

Angiotensin converting enzyme inhibition and chronic cyclosporine-induced renal dysfunction in type 1 diabetes

1996 • 16 citations

Effects of cyclosporine and its metabolites in the isolated perfused rat kidney.

1993 • 15 citations

High-Dosage Intravenous Immunoglobulin–Associated Macrovacuoles Are Associated with Chronic Tubulointerstitial Lesion Worsening in Renal Transplant Recipients

2008 • 14 citations

Nitric oxide in CsA-induced hypertension: role of β -adrenoceptor antagonist and thromboxane A2

2001 • 13 citations

Association of Cumulative Cyclosporine Dose with Its Irreversible Nephrotoxicity in Japanese Patients with Pediatric-Onset Autoimmune Diseases

2007 • 12 citations

Decreased mineralocorticoid receptor expression in blood cells of kidney transplant recipients undergoing immunosuppressive treatment: cost efficient determination by quantitative PCR

2003 • 12 citations

Cyclosporine nephrotoxicity in rheumatoid arthritis: no effect of short term misoprostol treatment.

1992 • 12 citations

THE EFFECTS OF AGE AND DOSAGE ROUTE ON EXPERIMENTAL CYCLOSPORINE NEPHROTOXICITY

1991 • 12 citations

Juxtaglomerular apparatus of the human kidney: correlation between structure and function.

1982 • 10 citations

Glomerulotubular function in cyclosporine-treated rats. A lithium clearance, occlusion time/transit time and micropuncture study.

1985 • 10 citations

Calcium antagonists in heart transplant recipients: effects on cardiac and renal function and cyclosporine pharmacokinetics.

1993 • 10 citations

Cyclosporine impairs the renal response to volume depletion.

1988 • 9 citations

Studies on morphological outcome of cyclosporine-associated arteriolopathy after discontinuation of cyclosporine in patients with renal allografts.

1993 • 9 citations

Potential Interaction between Prolonged Cyclosporin Administration and Aging in the Rat Kidney

1994 • 9 citations

Inhibition of Purified Human Kidney Na⁺,K⁺‐ATPase by Cyclosporine A

2003 • 8 citations

CNI sparing in de novo renal transplantation: 3-year results from the symphony study

2008 • 8 citations

Giant Mitochondria in “Zero-hour” Transplant Biopsies

1992 • 8 citations

MISOPROSTOL PARTIALLY INHIBITS THE RENAL SCARRING OF CHRONIC CYCLOSPORINE NEPHROTOXICITY

1995 • 8 citations

483: Calcineurin-inhibitor associated nephrotoxicity after orthotopic heart transplantation associated with single nucleotide polymorphisms (SNP)

2007 • 3 citations

42 Follow-up of Kidney Graft Recipients with Cyclosporine Associated Hemolytic Uremic Syndrome and Thrombotic Microangiopathy

2005 • 2 citations

VOCLOSPORIN (ISA 247): THE PHASE 2 'PROMISE' DE NOVO RENAL TRANSPLANT TRIAL DEMONSTRATES EFFICACY AND AN IMPROVED SAFETY PROFILE ACROSS A WIDE THERAPEUTIC RANGE

2008 • 1 citations