CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity.

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

Genetic Variation in HTLV-III/LAV Over Time in Patients with AIDS or at Risk for AIDS

1986 • 570 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

The kinetics of immune reconstitution after human marrow transplantation

1987 • 428 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity.

1983 • 351 citations

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.

1989 • 318 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

A model for the selective loss of major histocompatibility complex self-restricted T cell immune responses during the development of acquired immune deficiency syndrome (AIDS).

1986 • 212 citations

Activated lymphocytes during acute Epstein-Barr virus infection.

1987 • 178 citations

Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations.

1983 • 134 citations

Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population.

1990 • 131 citations

Phenotypic heterogeneity of cerebrospinal fluid-derived HIV-specific and HLA-restricted cytotoxic T-cell clones

1988 • 129 citations

Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T cells from an HIV-1-infected individual.

1988 • 129 citations

Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes.

1989 • 124 citations

Functional properties of T lymphocytes and their subsets in cytomegalovirus mononucleosis.

1983 • 93 citations

T-cell responses to human AIDS virus in macaques immunized with recombinant vaccinia viruses

1986 • 91 citations

Suppression of Immunoglobulin Synthesis by Lymphocyte Subpopulations in Patients With Crohn's Disease

1984 • 72 citations

Expression of HLA-DR, DQ and DP antigens and interleukin-2 receptor on synovial fluid T lymphocyte subsets in rheumatoid arthritis: evidence for "frustrated" activation.

1987 • 71 citations

Deficient, HLA-Restricted, Cytomegalovirus-Specific Cytotoxic T Cells and Natural Killer Cells in Patients with the Acquired Immunodeficiency Syndrome

1985 • 33 citations

Lysis of bystander target cells after triggering of human cytotoxic T lymphocytes

1986 • 26 citations

Characterization of lymphocytes that suppress IL-2 production in systemic lupus erythematosus.

1988 • 13 citations