Integrative Genomics Identifies Distinct Molecular Classes of Neuroblastoma and Shows That Multiple Genes Are Targeted by Regional Alterations in DNA Copy Number

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

The Human Genome Browser at UCSC

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The Protein Kinase Complement of the Human Genome

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

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Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.

1993 • 2,242 citations

Neuroblastoma: biological insights into a clinical enigma

2003 • 2,087 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Identifying biological themes within lists of genes with EASE

2003 • 1,969 citations

Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid

1999 • 1,843 citations

Senescence in premalignant tumours

2005 • 1,394 citations

Germ-Line Mutations in Nonsyndromic Pheochromocytoma

2002 • 1,342 citations

The International Neuroblastoma Pathology Classification (the Shimada system)

1999 • 966 citations

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

2000 • 799 citations

Gene Expression Profiling in Uveal Melanoma Reveals Two Molecular Classes and Predicts Metastatic Death

2004 • 703 citations

Molecular Biology of Neuroblastoma

1999 • 644 citations

Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.

1991 • 595 citations

Chromosome 1p and 11q Deletions and Outcome in Neuroblastoma

2005 • 546 citations

Gain of Chromosome Arm 17q and Adverse Outcome in Patients with Neuroblastoma

1999 • 543 citations

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

2005 • 448 citations

TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer

2001 • 438 citations

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer

1998 • 358 citations

Integrated Array-Comparative Genomic Hybridization and Expression Array Profiles Identify Clinically Relevant Molecular Subtypes of Glioblastoma

2005 • 326 citations

Statistical estimation of prognosis for children with neuroblastoma.

1971 • 321 citations

International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors

2001 • 277 citations

Analysis of chromosome breakpoints in neuroblastoma at sub‐kilobase resolution using fine‐tiling oligonucleotide array CGH

2005 • 273 citations

Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas

1999 • 250 citations

Biologic Factors Determine Prognosis in Infants With Stage IV Neuroblastoma: A Prospective Children’s Cancer Group Study

2000 • 238 citations

PPM1D is a potential target for 17q gain in neuroblastoma.

2003 • 228 citations

A Molecular Classification of Papillary Renal Cell Carcinoma

2005 • 226 citations

CpG Island Methylator Phenotype Is a Strong Determinant of Poor Prognosis in Neuroblastomas

2005 • 204 citations

The biologic basis for neuroblastoma heterogeneity and risk stratification

2005 • 197 citations

Allelic Losses at 1p36 and 19q13 in Gliomas: Correlation with Histologic Classification, Definition of a 150-kb Minimal Deleted Region on 1p36, and Evaluation of CAMTA1 as a Candidate Tumor Suppressor Gene

2005 • 183 citations

Unequivocal Delineation of Clinicogenetic Subgroups and Development of a New Model for Improved Outcome Prediction in Neuroblastoma

2005 • 181 citations

Prediction of Clinical Outcome Using Gene Expression Profiling and Artificial Neural Networks for Patients with Neuroblastoma

2004 • 178 citations

Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma

2004 • 166 citations

CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system

2003 • 164 citations

Loss of Heterozygosity at 1p36 Independently Predicts for Disease Progression But Not Decreased Overall Survival Probability in Neuroblastoma Patients: A Children’s Cancer Group Study

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RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis.

1998 • 148 citations

Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma

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Gene Expression of Parathyroid Tumors

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Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma.

2003 • 109 citations

Opsoclonus‐myoclonus‐ataxia syndrome in neuroblastoma: Histopathologic features–A report from the children's cancer group†

2001 • 107 citations

Generation of patterns from gene expression data by assigning confidence to differentially expressed genes

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High‐resolution detection and mapping of genomic DNA alterations in neuroblastoma

2005 • 98 citations

Detection of MYCN Gene Amplification in Neuroblastoma by Fluorescence In Situ Hybridization: A Pediatric Oncology Group Study

2001 • 90 citations

Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma

2004 • 87 citations

Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.

2002 • 87 citations

Inhibition of a New Differentiation Pathway in Neuroblastoma by Copy Number Defects of N-myc, Cdc42, and nm23 Genes

2005 • 83 citations

Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma.

2003 • 77 citations

Distinct CpG methylation profiles characterize different clinical groups of neuroblastic tumors

2005 • 74 citations

Oligonucleotide microarray analysis of gene expression in neuroblastoma displaying loss of chromosome 11q

2004 • 67 citations

Neuroblastic tumors associated with opsoclonus-myoclonus syndrome: histological, immunohistochemical and molecular features of 15 Italian cases

2003 • 67 citations

Coordinate Deletion of Chromosome 3p and 11q in Neuroblastoma Detected by Comparative Genomic Hybridization

2000 • 66 citations

Methylation-Associated Silencing of theNuclear Receptor 1I2Gene in Advanced-Type Neuroblastomas, Identified by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification

2005 • 63 citations

Gene expression profiling of 1p35–36 genes in neuroblastoma

2004 • 62 citations

Coupled analysis of gene expression and chromosomal location

2005 • 54 citations

Abnormal constitutional karyotypes in patients with neuroblastoma: a report of four new cases and review of 47 others in the literature

2003 • 47 citations

Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN

2002 • 46 citations

Inferring a Tumor Progression Model for Neuroblastoma From Genomic Data

2005 • 42 citations

Identification and high-resolution mapping of a constitutional 11q deletion in an infant with multifocal neuroblastoma

2003 • 41 citations

A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation.

2005 • 40 citations

Gene Profiling of High Risk Neuroblastoma

2005 • 39 citations

Expression Level of Neural Cell Adhesion Molecule (NCAM) Inversely Correlates with the Ability of Neuroblastoma Cells to Adhere to Endothelium In Vitro

2002 • 37 citations

High-Resolution Mapping of a 130-kb Core Region of theMYCNAmplicon in Neuroblastomas

1996 • 37 citations

Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology

2005 • 35 citations

ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas.

2003 • 29 citations

Detection of Single-Copy Chromosome 17q Gain in Human Neuroblastomas Using Real-Time Quantitative Polymerase Chain Reaction

2003 • 28 citations

MYCN Is the only highly expressed gene from the core amplified domain in human neuroblastomas

1998 • 23 citations

A review of DNA microarray analysis of human neuroblastomas

2005 • 21 citations

Prognostic value of MYCN and ID2 overexpression in neuroblastoma

2005 • 21 citations

Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11

2005 • 20 citations

No evidence for involvement of SDHD in neuroblastoma pathogenesis

2004 • 17 citations