Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

Principles and Practice of Pediatric Oncology

1990 • 2,002 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid

1999 • 1,843 citations

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

1973 • 1,284 citations

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

2000 • 1,073 citations

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

2000 • 799 citations

Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

2001 • 770 citations

Molecular Biology of Neuroblastoma

1999 • 644 citations

Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.

1991 • 595 citations

Gain of Chromosome Arm 17q and Adverse Outcome in Patients with Neuroblastoma

1999 • 543 citations

Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.

1989 • 466 citations

The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation

2002 • 389 citations

Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.

1999 • 366 citations

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex

2004 • 311 citations

The candidate tumor suppressor gene, RASSF1A , from human chromosome 3p21.3 is involved in kidney tumorigenesis

2001 • 296 citations

CpG island methylation in premalignant stages of gastric carcinoma.

2001 • 296 citations

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

1999 • 285 citations

Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines

2002 • 223 citations

Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study.

1998 • 221 citations

The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1

2002 • 217 citations

Amplification of cellular oncogenes: A predictor of clinical outcome in human cancer

1990 • 203 citations

Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma

2003 • 175 citations

Improved survival at 2 and 5 years in the LMCE1 unselected group of 72 children with stage IV neuroblastoma older than 1 year of age at diagnosis: is cure possible in a small subgroup?

1991 • 142 citations

RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours

2001 • 137 citations

Beyond the genetic lesions: gene inactivation by promoter hypermethylation in human cancer

2000 • 127 citations

Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells.

1994 • 111 citations

Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma.

2003 • 109 citations

Genetic Staging of Unresectable or Metastatic Neuroblastomain Infants: a Pediatric Oncology Group Study

1997 • 108 citations

Natural History and Biology of Stage A Neuroblastoma: A Pediatric Oncology Group Study

2000 • 99 citations

Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma

2003 • 90 citations

Prolonged N-myc protein half-life in a neuroblastoma cell line lacking N-myc amplification.

1990 • 86 citations

Clustering of hypermethylated genes in neuroblastoma

2003 • 83 citations

Differential expression of N-myc in phenotypically distinct subclones of a human neuroblastoma cell line.

1991 • 62 citations

Combined M‐FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines

2001 • 50 citations

Comparative genomic hybridization analysis of human neuroblastomas: Detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines

1997 • 47 citations

Hypermethylation‐mediated regulation of CD44 gene expression in human neuroblastoma

2002 • 39 citations