The evolutionary history of the CCR5-Δ32 HIV-resistance mutation

Infectious Diseases of Humans: Dynamics and Control

1992 • 7,897 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations.

1991 • 2,351 citations

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

1999 • 2,083 citations

Infectious diseases of humans: Dynamics and control

1991 • 1,665 citations

Smallpox and its eradication

1988 • 1,387 citations

Smallpox and its eradication

1989 • 1,365 citations

Human Genetics. Problems and Approaches.

1980 • 1,010 citations

Highly Active Antiretroviral Therapy in a Large Urban Clinic: Risk Factors for Virologic Failure and Adverse Drug Reactions

1999 • 850 citations

Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant

1998 • 725 citations

The Influence ofHLAGenotype on AIDS

2003 • 724 citations

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

1997 • 722 citations

Poxviruses and Immune Evasion

2003 • 639 citations

Requirement of Mip-1α for an Inflammatory Response to Viral Infection

1995 • 636 citations

Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland

1992 • 571 citations

Global distribution of the CCR5 gene 32-basepair deletion

1997 • 546 citations

Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes

1998 • 527 citations

Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5

1998 • 467 citations

The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

1997 • 454 citations

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

2000 • 430 citations

Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

1997 • 423 citations

Transmission of antiretroviral-drug-resistant HIV-1 variants

1999 • 401 citations

Plague, Population and the English Economy 1348–1530

1977 • 389 citations

Mechanism of Transdominant Inhibition of CCR5-mediated HIV-1 Infection by ccr5Δ32

1997 • 371 citations

CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

2000 • 340 citations

Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys).

1986 • 313 citations

Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry

1997 • 307 citations

The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe

1998 • 292 citations

Evaluating plague and smallpox as historical selective pressures for theCCR5-Δ32HIV-resistance allele

2003 • 267 citations

The effect of genetic variation in chemokines and their receptorson HIV transmission and progression to AIDS

2000 • 256 citations

A strong signature of balancing selection in the 5′ cis -regulatory region of CCR5

2002 • 239 citations

Normal T-Cell Turnover in Sooty Mangabeys Harboring Active Simian Immunodeficiency Virus Infection

2000 • 197 citations

The Black Death: Natural and Human Disaster in Medieval Europe

1984 • 169 citations

Cutting Edge: Role of C-C Chemokine Receptor 5 in Organ-Specific and Innate Immunity toCryptococcus neoformans

1999 • 168 citations

Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice.

1999 • 163 citations

The Black Death: natural and human disaster in medieval Europe.

1983 • 151 citations

Use of Chemokine Receptors by Poxviruses

1999 • 147 citations

Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients.

1997 • 147 citations

Defects in the Generation of IFN-γ Are Overcome to Control Infection withLeishmania donovaniin CC Chemokine Receptor (CCR) 5-, Macrophage Inflammatory Protein-1α-, or CCR2-Deficient Mice

1999 • 131 citations

Natural Infection of a Homozygous Δ24 CCR5 Red-capped Mangabey with an R2b-Tropic Simian Immunodeficiency Virus

1998 • 129 citations

Viruses, plagues, and history

1998 • 125 citations

In Search of AIDS-Resistance Genes

1997 • 124 citations

Chemokines and HIV-1 second receptors: The therapeutic connection

1998 • 118 citations

Host genetic influences on HIV-1 pathogenesis

1999 • 110 citations

Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus

1999 • 107 citations

The Bubonic Plague

1988 • 102 citations

CCR5 mutation and plague protection

2004 • 100 citations

Simulating genealogies of selected alleles in a population of variable size

2001 • 84 citations

Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans

2000 • 79 citations

Distribution of the CCR5 Gene 32-bp Deletion in Europe

1998 • 71 citations

Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids.

1990 • 64 citations

Natural selection and resistance to HIV

2001 • 61 citations

A Soluble Chemokine-Binding Protein from Vaccinia Virus Reduces Virus Virulence and the Inflammatory Response to Infection

2003 • 60 citations

Distribution of the CCR5 gene 32-basepair deletion in West Europe. A hypothesis about the possible dispersion of the mutation by the vikings in historical times

2001 • 56 citations

Decreased CCR5 Expression on CD4⁺T Cells of SIV-Infected Sooty Mangabeys

2003 • 45 citations

Distribution of the CCR5 gene 32 base pair deletion and SDF1-3'A variant in healthy individuals from different populations

1998 • 42 citations

Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus

1998 • 38 citations

The Demography of Early Modern Towns: York in the Sixteenth and Seventeenth Centuries

1998 • 35 citations

Analysis of CCR5Δ32 Geographic Distribution and Its Correlation with Some Climatic and Geographic Factors

2002 • 33 citations

Prevalence of CCR5 and CCR2 HIV-Coreceptor Gene Polymorphisms in Belgium

2000 • 31 citations

A survey for 32 nucleotide deletion in the CCR-5 chemokine receptor gene (Δccr-5) conferring resistance to human immunodeficiency virus type 1 in different ethnic groups and in chimpanzees

1998 • 29 citations

Impact of host genetics on HIV disease progression and treatment

2004 • 28 citations

Frequency of a Mutated CCR-5 Allele (Delta32) among Italian Healthy Donors and Individuals at Risk of Parenteral HIV Infection

1999 • 26 citations

High frequency of the HIV-1 protective CCR5 delta32 deletion in native Estonians.

2000 • 21 citations

Fraction of Cases of Acquired Immunodeficiency Syndrome Prevented by the Interactions of Identified Restriction Gene Variants

2004 • 19 citations

Intra- and Interspecific Variation of the CCR5 Gene in Higher Primates

2003 • 19 citations

Intense selection in an age–structured population

2004 • 18 citations

Fréquences de la mutation Δ32 du gène du corécepteur CCR5 dans les différentes régions françaises

1998 • 14 citations

When Plague Strikes: The Black Death, Smallpox, AIDS

1995 • 8 citations

Contrasting Frequencies of CCR5Δ32 and CCR2-64I Alleles in the Tunisian Population

2001 • 7 citations