Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes

Principles of Population Genetics.

1990 • 5,413 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

A comprehensive genetic map of the human genome based on 5,264 microsatellites

1996 • 2,983 citations

Mitochondrial DNA and human evolution

1987 • 2,967 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations.

1991 • 2,351 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

1988 • 1,968 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

Gene genealogies and the coalescent process.

1990 • 1,776 citations

Mutation of human short tandem repeats

1993 • 1,584 citations

The role of a mutant CCR5 allele in HIV–1 transmission and disease progression

1996 • 1,364 citations

African Populations and the Evolution of Human Mitochondrial DNA

1991 • 1,320 citations

Human Genetics. Problems and Approaches.

1980 • 1,010 citations

Principles of population genetics

1990 • 971 citations

Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression

1997 • 899 citations

Genetic absolute dating based on microsatellites and the origin of modern humans.

1995 • 775 citations

Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene

1996 • 701 citations

Chemokine receptors: Gateways to inflammation and infection

1996 • 659 citations

Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.

1995 • 600 citations

Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

1996 • 593 citations

The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells

1997 • 564 citations

Theoretical Aspects of Population Genetics.

1972 • 551 citations

Global distribution of the CCR5 gene 32-basepair deletion

1997 • 546 citations

Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model

1994 • 483 citations

The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

1997 • 454 citations

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α

1996 • 454 citations

Plagues and People

1977 • 443 citations

Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population

1995 • 426 citations

Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

1997 • 423 citations

The origin of the major cystic fibrosis mutation (ΔF508) in European populations

1994 • 349 citations

Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein

1997 • 310 citations

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β, and RANTES

1996 • 301 citations

The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe

1998 • 292 citations

Is the most frequent allele the oldest?

1977 • 275 citations

Increased virulence of Yersinia pseudotuberculosis by two independent mutations

1988 • 266 citations

THE AGE OF A NEUTRAL MUTANT PERSISTING IN A FINITE POPULATION

1973 • 247 citations

Polymorphism and balancing selection at major histocompatibility complex loci.

1992 • 204 citations

The Myth of Eve: Molecular Biology and Human Origins: F. J. Ayala

1995 • 174 citations

The coding sequence of Duffy blood group gene in humans and simians: restriction fragment length polymorphism, antibody and malarial parasite specificities, and expression in nonerythroid tissues in Duffy- negative individuals

1995 • 158 citations

Novel Alleles of the Chemokine-Receptor Gene CCR5

1997 • 149 citations

In Search of AIDS-Resistance Genes

1997 • 124 citations

The genetical archaeology of the human genome

1996 • 122 citations

New Approaches to Dating Suggest a Recent Age for the Human mtDNA Ancestor

1993 • 121 citations

Mitochondrial COII sequences and modern human origins.

1993 • 108 citations

THEORETICAL ASPECTS OF POPULATION GENETICS

1972 • 107 citations

The Bubonic Plague

1988 • 102 citations

Human Genetics. Problems and Approaches

1981 • 97 citations

New approaches to dating suggest a recent age for the human mtDNA ancestor

1992 • 88 citations

The Evolution of Human Populations: A Molecular Perspective

1996 • 81 citations

Ghetto Legacy: Can the High Incidence of Tay-Sachs Disease in Ashkenazi Jews be Linked to Historic Epidemics of Tuberculosis in Industrial European Cities?

1991 • 44 citations

Evolution of plague virulence

1988 • 40 citations

ON THE DIVERGENCE OF ALLELES IN NESTED SUBSAMPLES FROM FINITE POPULATIONS

1986 • 33 citations

Mitochondrial COII Sequences and Modern Human Origins

1994 • 30 citations

OH–IR sources as precursors to protoplanetary nebulae

1990 • 26 citations

Ghetto legacy

1991 • 21 citations

Possible association of the allele status of the CS.7/ Hha I polymorphism 5′ of the CFTR gene with postnatal female survival

1997 • 15 citations

Association of duffy blood groups with the suckle cell trait

1976 • 15 citations

Theoretical Aspects of Population Genetics.

1973 • 14 citations