Transplantation of Cultured Islets from Two-Layer Preserved Pancreases in Type 1 Diabetes with Anti-CD3 Antibody

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

1997 • 6,073 citations

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Long-Term Complications of Diabetes Mellitus

1993 • 1,460 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Automated Method for Isolation of Human Pancreatic Islets

1988 • 1,282 citations

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

2002 • 1,189 citations

Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

2001 • 864 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

1994 • 640 citations

Reduced Awareness of Hypoglycemia in Adults With IDDM: A prospective study of hypoglycemic frequency and associated symptoms

1995 • 589 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

Islet isolation assessment in man and large animals

1990 • 575 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

Can clinical factors estimate insulin resistance in type 1 diabetes?

2000 • 481 citations

IN VIVO CELL ACTIVATION FOLLOWING OKT3 ADMINISTRATION

1990 • 309 citations

Epidemiology of severe hypoglycemia in the diabetes control and complications trial

1991 • 307 citations

CD3-specific antibody-induced active tolerance: from bench to bedside

2003 • 305 citations

Improved Human Islet Isolation Using a New Enzyme Blend, Liberase

1997 • 303 citations

Large-Scale Purification of Human Islets Utilizing Discontinuous Albumin Gradient on IBM 2991 Cell Separator

1989 • 207 citations

Intraductal Collagenase Delivery into the Human Pancreas Using Syringe Loading or Controlled Perfusion

1999 • 204 citations

PHASE I TRIAL OF A HUMANIZED, Fc RECEPTOR NONBINDING OKT3 ANTIBODY, huOKT3??1 (Ala-Ala) IN THE TREATMENT OF ACUTE RENAL ALLOGRAFT REJECTION

1999 • 189 citations

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)

2003 • 177 citations

A NON-ACTIVATING “HUMANIZED” ANTI-CD3 MONOCLONAL ANTIBODY RETAINS IMMUNOSUPPRESSIVE PROPERTIES IN VIVO

1994 • 170 citations

Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution

2003 • 164 citations

Successful islet autotransplantation in humans: functional insulin secretory reserve as an estimate of surviving islet cell mass.

1998 • 148 citations

A NEW, SIMPLE METHOD FOR COLD STORAGE OF THE PANCREAS USING PERFLUOROCHEMICAL

1988 • 147 citations

INDUCTION OF LONG-TERM SPECIFIC TOLERANCE TO ALLOGRAFTS IN RATS BY THERAPY WITH AN ANTI-CD3-LIKE MONOCLONAL ANTIBODY

1993 • 144 citations

A Multicenter Evaluation of Blood Glucose Awareness Training-II

1995 • 129 citations

Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method

2002 • 125 citations

Perfluorocarbon for organ preservation before transplantation1

2002 • 110 citations

Impact of two-layer pancreas preservation on islet isolation and transplantation1

2002 • 98 citations

A COMPARISON OF MEDIA SUPPLEMENT METHODS FOR THE EXTENDED CULTURE OF HUMAN ISLET TISSUE1

1998 • 83 citations

CLINICAL APPLICATION OF THE TWO-LAYER (UNIVERSITY OF WISCONSIN SOLUTION/PERFLUOROCHEMICAL PLUS O 2) METHOD OF PANCREAS PRESERVATION BEFORE TRANSPLANTATION

2000 • 82 citations

Preservation of the human pancreas before islet isolation using a two-layer (UW solution???perfluorochemical) cold storage method1

2002 • 69 citations

Excellence of the two-layer method (University of Wisconsin solution/perfluorochemical) in pancreas preservation before islet isolation

1997 • 69 citations

Pancreatic secretory trypsin inhibitor as a marker for early detection of rejection in canine pancreas allotransplantation.

1989 • 62 citations

LESSER REDUCTION IN BONE MINERAL DENSITY BY THE IMMUNOSUPPRESSANT, FK506, COMPARED WITH CYCLOSPORINE IN RATS

2000 • 61 citations

Combined hepatic and pancreaticoduodenal procurement for transplantation.

1989 • 56 citations

USE OF OXYGENATED PERFLUOROCARBON TOWARD MAKING EVERY PANCREAS COUNT

2002 • 54 citations

Successful Single Donor Islet Allotransplantation in the Streptozotocin Diabetes Rat Model

2002 • 47 citations

New protocol toward prevention of early human islet allograft failure.

1994 • 34 citations

Humoral immune response against OKT3.

1993 • 29 citations

CD4+, CD25+ T cells as regulators of alloimmune responses

2001 • 19 citations

IN VIVO SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR RELEASE IN OKT3-TREATED PATIENTS

1995 • 12 citations

Long-term culture of viable human pancreatic islets in pyruvate-rich medium.

1995 • 11 citations

Optimal temperature in pancreas preservation by the two-layer cold storage method before islet isolation

2001 • 8 citations

INSULIN-LIKE GROWTH FACTORS PROMOTE ISLET CELL SURVIVAL IN VITRO THROUGH MAP KINASE MEDIATED SIGNALING.

2000 • 2 citations

Significant impact of two layer (Perfluorochemical/University of Wisconsin solution (PFC/ UW)) method on islet yield and function for short-term preservation of human donor pancreata prior to islet isolation and transplantation

2003 • 2 citations