Increased production of the TrkB protein tyrosine kinase receptor after brain insults

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

1992 • 752 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model

1984 • 741 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF

1991 • 699 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

1984 • 598 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery

1987 • 558 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

1990 • 529 citations

Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.

1992 • 521 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1991 • 462 citations

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

1979 • 422 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization

1990 • 365 citations

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

1988 • 356 citations

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

1992 • 336 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons

1989 • 331 citations

Hypoglycemic Brain Injury in the Rat: Correlation of Density of Brain Damage with the EEG Isoelectric Time: A Quantitative Study

1984 • 328 citations

Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain

1991 • 295 citations

Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

1991 • 294 citations

Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus

1991 • 280 citations

Epidermal growth factor regulates the expression of its own receptor.

1985 • 253 citations

Developmental and regional expression of β-nerve growth factor receptor mRNA in the chick and rat

1988 • 245 citations

Cloning and expression of a cDNA encoding a novel human neurotrophic factor

1990 • 199 citations

Kindling with rapidly recurring hippocampal seizures

1985 • 182 citations

Properties of the β Nerve Growth Factor Receptor of Avian Dorsal Root Ganglia

1973 • 179 citations

Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid

1992 • 174 citations

Regulation of receptor expression by agonists: transcriptional and post-transcriptional controls

1991 • 103 citations

NGF in CNS: Experimental data and clinical implications

1989 • 97 citations

Ischemia-induced changes in the electrical activity of the hippocampus

1989 • 94 citations

Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures

1992 • 90 citations

Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study

1984 • 73 citations

Noradrenergic mechanisms in hippocampal kindling with rapidly recurring seizures

1989 • 48 citations

Visualization and Quantitation of Neurotrophin mRNAs

2003 • 2 citations