BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

2002 • 1,676 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Formation of mRNA 3′ Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis

1999 • 1,016 citations

Nuclear speckles: a model for nuclear organelles

2003 • 955 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

1997 • 905 citations

How the ubiquitin–proteasome system controls transcription

2003 • 790 citations

The ubiquitin ligase COP1 is a critical negative regulator of p53

2004 • 693 citations

The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

2001 • 623 citations

RNA polymerase II and the integration of nuclear events

2000 • 561 citations

BRCA1 is a component of the RNA polymerase II holoenzyme

1997 • 450 citations

Failure of RNA synthesis to recover after UV irradiation; An early defect in cells from individuals with Cockayne syndrome and xeroderma pigmentosum

1982 • 418 citations

The Polyadenylation Factor CstF-64 Regulates Alternative Processing of IgM Heavy Chain Pre-mRNA during B Cell Differentiation

1996 • 416 citations

Mechanisms of transcription-coupled DNA repair

2002 • 377 citations

RNA polymerase II is an essential mRNA polyadenylation factor

1998 • 358 citations

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

2002 • 349 citations

The ends of the affair: capping and polyadenylation.

2000 • 340 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.

1996 • 313 citations

The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

2003 • 291 citations

BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

2004 • 287 citations

Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

2003 • 278 citations

Direct DNA binding by Brca1

2001 • 277 citations

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

2002 • 274 citations

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

2002 • 260 citations

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair

2003 • 243 citations

Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase

2004 • 241 citations

A Rad26–Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage

2002 • 230 citations

BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

1999 • 229 citations

Ultraviolet Radiation-induced Ubiquitination and Proteasomal Degradation of the Large Subunit of RNA Polymerase II

1998 • 221 citations

Levels of Polyadenylation Factor CstF-64 Control IgM Heavy Chain mRNA Accumulation and Other Events Associated with B Cell Differentiation

1998 • 220 citations

Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase

2002 • 218 citations

The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression

2001 • 210 citations

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1997 • 206 citations

Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein

2003 • 199 citations

BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

2000 • 197 citations

Functional Interaction of BRCA1-Associated BARD1 with Polyadenylation Factor CstF-50

1999 • 194 citations

Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro

2002 • 170 citations

Rsp5 Ubiquitin-Protein Ligase Mediates DNA Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae

1999 • 169 citations

Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

1997 • 161 citations

Alternative Polyadenylation Events Contribute to the Induction of NF-ATc in Effector T Cells

1999 • 160 citations

Nucleophosmin/B23 Is a Candidate Substrate for the BRCA1-BARD1 Ubiquitin Ligase

2004 • 144 citations

Structural Characterization of RNA Polymerase II Complexes Arrested by a Cyclobutane Pyrimidine Dimer in the Transcribed Strand of Template DNA

1999 • 142 citations

Ubiquitination and Proteasomal Degradation of the BRCA1 Tumor Suppressor Is Regulated during Cell Cycle Progression

2004 • 120 citations

The RNA 3′ cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA.

1996 • 103 citations

Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain

1999 • 99 citations

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

2003 • 75 citations

BRCA1 Associates with Processive RNA Polymerase II

2003 • 74 citations

Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation

2001 • 73 citations

UV light-induced degradation of RNA polymerase II is dependent on the Cockayne’s syndrome A and B proteins but not p53 or MLH1

2001 • 64 citations

Redistribution of BRCA1 among Four Different Protein Complexes following Replication Blockage

2001 • 60 citations

The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme.

2002 • 53 citations

siRNA depletion of BRCA1, but not BRCA2, causes increased genome instability in Fanconi anemia cells

2003 • 52 citations

When machines get stuck—obstructed RNA polymerase II: displacement, degradation or suicide

2002 • 47 citations

Creatine Phosphate, Not ATP, Is Required for 3′ End Cleavage of Mammalian Pre-mRNA in Vitro

1997 • 40 citations

Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair

1998 • 33 citations

Polyadenylate Polymerase (PAP) and 3' End pre-mRNA Processing: Function, Assays, and Association with Disease

2002 • 33 citations

Transcription response and nucleotide excision repair

1998 • 24 citations

Transcription-coupled DNA repair in yeast transcription factor IIE (TFIIE) mutants

2000 • 6 citations