Anti-Inflammatory Effects of Mitogen-Activated Protein Kinase Kinase Inhibitor U0126 in an Asthma Mouse Model

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Asthma

2001 • 1,547 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

1997 • 1,294 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

IL-13 Effector Functions

2003 • 910 citations

Mechanisms of eosinophil-associated inflammation

2000 • 773 citations

Regulation of mast-cell and basophil function and survival by IgE

2002 • 626 citations

The role of T lymphocytes in the pathogenesis of asthma

2003 • 572 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Effects of Th2 Cytokines on Chemokine Expression in the Lung: IL-13 Potently Induces Eotaxin Expression by Airway Epithelial Cells

1999 • 397 citations

To respond or not to respond: T cells in allergic asthma

2003 • 334 citations

Role of chemokines in the pathogenesis of asthma

2001 • 296 citations

Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases

2000 • 280 citations

B Cell Antigen Receptor Signaling: Roles in Cell Development and Disease

2002 • 263 citations

IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation

2003 • 258 citations

Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase–TAT

2003 • 238 citations

Direct Effects of Interleukin-13 on Signaling Pathways for Physiological Responses in Cultured Human Airway Smooth Muscle Cells

2001 • 216 citations

T-cell activation through the antigen receptor. Part 1: Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse

2002 • 210 citations

Extracellular signal–regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells

2001 • 207 citations

Signal Transduction by the High-Affinity Immunoglobulin E Receptor FcεRI: Coupling Form to Function

2001 • 206 citations

Interleukin (IL)-4–independent Induction of Immunoglobulin (Ig)E, and Perturbation of T Cell Development in Transgenic Mice Expressing IL-13

1998 • 182 citations

The Role of IL-13 in Established Allergic Airway Disease

2002 • 175 citations

T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction.

1995 • 171 citations

Lyn, Jak2, and Raf-1 Kinases Are Critical for the Antiapoptotic Effect of Interleukin 5, whereas only Raf-1 Kinase Is Essential for Eosinophil Activation and Degranulation

1998 • 161 citations

IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK

2002 • 158 citations

Selective Induction of Eotaxin Release by Interleukin-13 or Interleukin-4 in Human Airway Smooth Muscle Cells Is Synergistic with Interleukin-1 β and Is Mediated by the Interleukin-4 Receptor α -Chain

2002 • 145 citations

Role of TCR-Induced Extracellular Signal-Regulated Kinase Activation in the Regulation of Early IL-4 Expression in Naive CD4+ T Cells

2003 • 143 citations

The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma

2001 • 143 citations

Activation of Mitogen-Activated Protein Kinase Regulates Eotaxin-Induced Eosinophil Migration

1999 • 142 citations

Inhibition of the MEK/ERK Signaling Pathway Blocks a Subset of B Cell Responses to Antigen

2001 • 131 citations

Role of activator protein 1, nuclear factor-κB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells

2003 • 109 citations

Leukotrienes Mediate Murine Bronchopulmonary Hyperreactivity, Inflammation, and Part of Mucosal Metaplasia and Tissue Injury Induced by Recombinant Murine Interleukin-13

2003 • 107 citations

Mechanical stretch activates nuclear factor‐kappaB, activator protein‐1, and mitogen‐activated protein kinases in lung parenchyma: implications in asthma

2003 • 100 citations

Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions

1999 • 93 citations

Convergence of Signaling Pathways on the Activation of ERK in B Cells

2002 • 89 citations

Airway smooth muscle: An immunomodulatory cell

2002 • 73 citations

Invited Review: Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?

2003 • 73 citations

Oncostatin M Regulates Eotaxin Expression in Fibroblasts and Eosinophilic Inflammation in C57BL/6 Mice

2003 • 64 citations

Regulation of IL‐13 synthesis in human lymphocytes: implications for asthma therapy

2002 • 51 citations

CD4⁺T cell-dependent airway mucus production occurs in response to IL-5 expression in lung

2002 • 47 citations

The Role of Mitogen-Activated Protein Kinases in Eotaxin-Induced Cytokine Production from Bronchial Epithelial Cells

2002 • 31 citations

Early Interleukin 4–Dependent Response Can Induce Airway Hyperreactivity before Development of Airway Inflammation in a Mouse Model of Asthma

2001 • 31 citations

Effects of mitogen‐activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea‐pig airways in vitro

1998 • 26 citations

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