Role of TCR-Induced Extracellular Signal-Regulated Kinase Activation in the Regulation of Early IL-4 Expression in Naive CD4+ T Cells

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Partners in transcription: NFAT and AP-1

2001 • 757 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity

2001 • 680 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Assessment of Cytokines by Immunofluorescence and the Paraformaldehyde‐Saponin Procedure

1991 • 465 citations

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1999 • 364 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun

2000 • 316 citations

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

1997 • 273 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

The NFAT-1 DNA Binding Complex in Activated T Cells Contains Fra-1 and JunB

1993 • 215 citations

T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation

1999 • 210 citations

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

1997 • 194 citations

Inhibition of T Cell Activation by Pharmacologic Disruption of the MEK1/ERK MAP Kinase or Calcineurin Signaling Pathways Results in Differential Modulation of Cytokine Production

1998 • 190 citations

Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

1999 • 186 citations

The Repertoire of Fos and Jun Proteins Expressed during the G₁ Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

1999 • 179 citations

Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells.

1995 • 178 citations

Mutation of Tec family kinases alters T helper cell differentiation

2001 • 174 citations

p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.

1993 • 167 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding.

1997 • 163 citations

Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization

2000 • 149 citations

Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity.

1994 • 137 citations

The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4+ T Cells

2002 • 136 citations

c-Jun NH₂-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1

2000 • 130 citations

Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV

1991 • 129 citations

MHC control of CD4+ T cell subset activation.

1989 • 121 citations

Transactivation of Fra-1 and Consequent Activation of AP-1 Occur Extracellular Signal-Regulated Kinase Dependently

2002 • 121 citations

Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype

1992 • 120 citations

Reprogramming the signalling requirement for AP‐1 (activator protein‐1) activation during differentiation of precursor CD4⁺ T‐cells into effector Th1 and Th2 cells

1997 • 115 citations

Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets.

1997 • 97 citations

Selective activation of the calcium signaling pathway by altered peptide ligands.

1996 • 83 citations

Differential activation of T cell cytokine production by the extracellular signal‐regulated kinase (ERK) signaling pathway

1996 • 58 citations

Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-γ production

2001 • 54 citations

Activation of the extracellular signal-regulated kinase pathway is differentially required for TCR-stimulated production of six cytokines in primary T lymphocytes.

1998 • 52 citations