Age-related changes in cytokine production by leukocytes in rhesus monkeys

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

1998 • 1,463 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation

1992 • 469 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation

1998 • 406 citations

Altered cytokine production in the elderly

1998 • 379 citations

Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.

1993 • 322 citations

Tumor-induced immune dysfunction

1999 • 239 citations

Dietary Restriction and Aging: The Initiation of a Primate Study

1990 • 220 citations

The Immune System in the Elderly: Activation-Induced and Damage-Induced Apoptosis

2004 • 204 citations

Dysregulation between TH1 and TH2 T cell subpopulations in the elderly

1996 • 178 citations

Discussion

1997 • 175 citations

Comparative sequence analysis of cytokine genes from human and nonhuman primates.

1995 • 152 citations

The immune S ystem in the elderly

1999 • 146 citations

The immune system in the elderly

1999 • 128 citations

The immune S ystem in the elderly

1999 • 118 citations

Nutritional influences on immune response in healthy aged persons

1998 • 100 citations

Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of healthy elderly individuals

1998 • 98 citations

The Role of Nutrition in Immunity in the Aged

2009 • 91 citations

Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL-10 and IL-12

1999 • 79 citations

Molecular and cellular basis of immunosenescence

1998 • 72 citations

In vivo T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women.

1992 • 71 citations

Dietary Restriction in Nonhuman Primates: Progress Report on the NIA Study

1992 • 66 citations

Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta).

1995 • 63 citations

Reduced interferon-gamma (IFN-γ) secretion with increased IFN-γ mRNA expression in atopic dermatitis: evidence for a post-transcriptional defect

1994 • 56 citations

Adult-Onset Energy Restriction of Rhesus Monkeys Attenuates Oxidative Stress–Induced Cytokine Expression by Peripheral Blood Mononuclear Cells

1997 • 54 citations

Diet modulates Th-1 and Th-2 cytokine production in the peripheral blood of lupus-prone mice.

1999 • 47 citations

Expression of interleukin 2 and the interleukin 2 receptor in aging rats

1989 • 41 citations

Effect of age on cytokine production in humans

1998 • 41 citations

Age-related alteration of cytokine production profile by T cell subsets in mice: a flow cytometric study

1999 • 32 citations

The Immunology of Ageing

1986 • 21 citations

Production of human α‐ and γ‐interferon is dependent on age and sex and is decreased in rheumatoid arthritis: A simple method for a large‐scale assay

1991 • 21 citations

Autoantibody Production in Healthy Elderly People is not Promoted by Interleukin‐10 Although This Cytokine is Expressed in Them by a Peculiar CD8⁺CD3⁺ Large Granular Cell Subpopulation

1997 • 16 citations

A simple and rapid method to analyze specific mRNAs from few cells in a semi-quantitative way using the polymerase chain reaction.

1991 • 15 citations

Immunoreactive Cytokines within Primates

1996 • 4 citations