The Immunology of Ageing

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

Age Influence on the Immune System

1980 • 703 citations

AGEING, IMMUNE RESPONSE, AND MORTALITY

1974 • 480 citations

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

1981 • 473 citations

Frequency of Pathological Proteins (M‐components) in 6,995 Sera from an Adult Population

1966 • 444 citations

Impaired Lymphocyte Function in Aged Humans

1974 • 350 citations

Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans

1973 • 286 citations

Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice.

1976 • 239 citations

Lymphokines and aging: interleukin-2 production and activity in aged animals.

1981 • 234 citations

Enumeration of T lymphocyte subsets by monoclonal antibodies in young and aged humans.

1981 • 187 citations

Impaired Delayed Hypersensitivity in an Aging Population

1968 • 183 citations

Thymic Involution: Effect on T Cell Differentiation

1975 • 183 citations

Immunological responses of healthy elderly population.

1982 • 177 citations

Suppressor Lymphocytes in Young and Aged Humans

1977 • 169 citations

The immunologic theory of aging

1970 • 168 citations

Frequency of “Abnormal” Serum Globulins (M‐Components) in the Aged

1963 • 157 citations

Ageing and Immunological Function in Man

1972 • 118 citations

Immunologic studies of aging. V. Impaired proliferation of PHA responsive human lymphocytes in culture.

1980 • 116 citations

Characterization of immunoregulatory T lymphocytes during ageing by monoclonal antibodies.

1982 • 87 citations

RELATIVE ANTIBODY-FORMING CAPACITY OF SPLEEN CELLS AS A FUNCTION OF AGE

1962 • 84 citations

Immunologic Basis for Susceptibility to Infection in the Aged

1984 • 81 citations

DIABETES MELLITUS, AUTOIMMUNITY, AND AGEING

1971 • 79 citations

Production of auto-anti-idiotypic antibody during the normal immune response: changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging.

1980 • 77 citations

Subpopulations of human T lymphocytes. X. Alterations in T, B, third population cells, and T cells with receptors for immunoglobulin M (Tmu) or G (Tgamma) in aging humans.

1979 • 72 citations

Age-dependent variations of antibody avidity.

1978 • 69 citations

Circulating immune complexes in old people and in diabetics: correlation with autoantibodies.

1980 • 66 citations

Age-related changes in human thymus.

1979 • 53 citations

Autoantibodies in healthy subjects of different age groups

1979 • 52 citations

Effect of age on response to T- and B-cell mitogens in mice congenic at theH-2 locus

1977 • 47 citations

IgE mediated hypersensitivity in ageing

1977 • 45 citations

Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging.

1979 • 41 citations

Immunopathology of aging.

1974 • 38 citations

Disturbance of Redistribution of Surface Membrane Receptors on Peripheral Mononuclear Cells of Patients With Down's Syndrome and of Aged Individuals

1980 • 36 citations

Immunopathology of aging

1974 • 33 citations

Subpopulations of Human T Lymphocytes

1979 • 33 citations

Blood Group Antibodies in Old Age

1972 • 30 citations

Histocompatibility determinants, immune responsiveness and aging in man.

1978 • 25 citations

Cell-mediated cytotoxicity in humans: Age-related decline as measured by a xenogeneic assay

1979 • 23 citations

Effect of age on ease of B-cell tolerance induction

1980 • 21 citations

Parainfluenza infection of aged mice results in autoimmune disease

1979 • 20 citations

Have we underestimated the importance of the thymus in man?

1984 • 20 citations

T-cell division and aging

1979 • 19 citations

Serum anti-gamma-globulin and antinuclear factors in the aged

1967 • 13 citations

Effect of aging on T-cell tolerance induction

1980 • 12 citations

Reduced lymphocyte colony formation with age.

1982 • 11 citations

Effect of food on antacid neutralizing capacity in man

1982 • 10 citations

Effects of age on cellular immune responses in BALB/cJ mice: Increase in antibody-dependent T lymphocyte mediated cytotoxicity

1979 • 10 citations

Immune function during ageing in man: relation between serological abnormalities and cellular immune status

1983 • 9 citations