Age-related alteration of cytokine production profile by T cell subsets in mice: a flow cytometric study

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes.

1986 • 847 citations

Age Influence on the Immune System

1980 • 703 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

Assessment of Cytokines by Immunofluorescence and the Paraformaldehyde‐Saponin Procedure

1991 • 465 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Understanding the mechanism of the age-change of thymic function to promote T cell differentiation

1994 • 119 citations

Cytokine production by T lymphocytes from young and aged mice.

1996 • 99 citations

Measurement of intracellular cytokines

1996 • 69 citations

Influence of age on the signal transduction of T cells in mice

1993 • 60 citations

The role of thymus in the aging of T_h cell subpopulations and age-associated alteration of cytokine production by these cells

1995 • 60 citations

Age-related changes of splenic T cells in mice — a flow cytometric analysis

1987 • 59 citations

Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis

1997 • 59 citations

Impairment of signal transduction in T cells from old mice

1997 • 58 citations

Involvement of IL-4-producing Vbeta8.2+ CD4+ CD62L- CD45RB- T cells in non-MHC gene-controlled predisposition toward skewing into T helper type-2 immunity in BALB/c mice.

1997 • 58 citations

A shift to Th0 cytokine production by CD4⁺ cells in human longevity: Studies on two healthy centenarians

1996 • 50 citations

Effects of the aged microenvironment on CD4+ T cell maturation

1997 • 35 citations

Abnormality in the Early Signal Transduction Pathway is Responsible for the Impaired Proliferative Response and Low K Current in a T-cell Clone by Stimulation with Anti-CD3 Antibody

1996 • 8 citations