T Cell Receptor (TCR) Engagement Leads to Activation-induced Splicing of Tumor Necrosis Factor (TNF) Nuclear Pre-mRNA

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

The acute phase response

1994 • 2,927 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

IN VIVO CELL ACTIVATION FOLLOWING OKT3 ADMINISTRATION

1990 • 309 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Cytokine‐related syndrome following injection of anti‐CD3 monoclonal antibody: Further evidence for transient in vivo T cell activation

1990 • 267 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes.

1988 • 227 citations

Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma

1987 • 200 citations

Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines.

1991 • 138 citations

Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing.

1995 • 118 citations

Adenovirus-Mediated Blockade Of Tumor Necrosis Factor In Mice Protects Against Endotoxic Shock Yet Impairs Pulmonary Host Defense

1995 • 98 citations

Hypothermia and hypoglycemia induced by anti‐CD3 monoclonal antibody in mice: Role of tumor necrosis factor

1990 • 83 citations

Endotoxin-induced cytokine gene expression in vivo. I. Expression of tumor necrosis factor mRNA in visceral organs under physiologic conditions and during endotoxemia.

1989 • 79 citations

Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts.

1994 • 75 citations

Altered protein tyrosine phosphorylation in anergic Th1 cells.

1993 • 65 citations

Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B

1994 • 65 citations

Change in plasma membrane Ca2+-ATPase splice-variant expression in response to a rise in intracellular Ca2+

1996 • 62 citations

Complex regulation of tumor necrosis factor mRNA turnover in lipopolysaccharide-activated macrophages

1991 • 60 citations

Biochemical Mechanisms Of Constitutive And Regulated Pre-Messenger RNA Splicing

1991 • 54 citations

2-Aminopurine Selectively Inhibits Splicing of Tumor Necrosis Factor Alpha mRNA

1996 • 46 citations

Accelerated β-cell Destruction in Adoptively Transferred Autoimmune Diabetes Correlates With an Increased Expression of the Genes Coding for TNF-α and Granzyme A in the Intra-Islet Infiltrates

1995 • 32 citations

Molecular control of tissue‐specific expression at the mouse TNF locus

1989 • 31 citations

Post-transcriptional Regulation of Human Interleukin-2 Gene Expression at Processing of Precursor Transcripts

1995 • 29 citations

Comparative expression of TNF-alpha alleles from normal and autoimmune-prone MHC haplotypes.

1995 • 20 citations

[Molecular cloning of genes coding for tumor necrosis factor. Complete nucleotide sequence of the genome copy of TNF-alpha in mice].

1987 • 4 citations