Soluble Dimeric Prion Protein Binds PrPSc In Vivo and Antagonizes Prion Disease

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

Eight prion strains have PrPSc molecules with different conformations

1998 • 1,236 citations

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1996 • 872 citations

Cell-free formation of protease-resistant prion protein

1994 • 872 citations

Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

1989 • 834 citations

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

2001 • 696 citations

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 • 696 citations

Non-genetic propagation of strain-specific properties of scrapie prion protein

1995 • 517 citations

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

1996 • 516 citations

A crucial role for B cells in neuroinvasive scrapie

1997 • 503 citations

Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform

1997 • 388 citations

Impaired Prion Replication in Spleens of Mice Lacking Functional Follicular Dendritic Cells

2000 • 354 citations

Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies

2001 • 348 citations

Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

1995 • 343 citations

Measurement of the scrapie agent using an incubation time interval assay

1982 • 339 citations

Complement facilitates early prion pathogenesis

2001 • 320 citations

No propagation of prions in mice devoid of PrP

1994 • 282 citations

The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.

1991 • 261 citations

High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene

1994 • 245 citations

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation.

1993 • 241 citations

Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie

2001 • 227 citations

Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state

1999 • 222 citations

Binding of disease-associated prion protein to plasminogen

2000 • 221 citations

Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG.

1991 • 181 citations

A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth

1995 • 168 citations

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.

1994 • 154 citations

Prions: health scare and biological challenge

2001 • 153 citations

Dominant-negative inhibition of prion replication in transgenic mice

2002 • 153 citations

Unusual Topogenic Sequence Directs Prion Protein Biogenesis

1990 • 137 citations

Attempts to restore scrapie prion infectivity after exposure to protein denaturants.

1993 • 130 citations

The prion's progress

1991 • 128 citations

Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-β receptor–IgG1 fusion protein

1996 • 125 citations

Prions and the Immune System: A Journey Through Gut, Spleen, and Nerves

2003 • 105 citations

A soluble form of prion protein in human cerebrospinal fluid: Implications for prion-related encephalopathies

1992 • 93 citations

Similar Turnover and Shedding of the Cellular Prion Protein in Primary Lymphoid and Neuronal Cells

2001 • 88 citations

Interventional strategies against prion diseases

2001 • 82 citations

Small is not beautiful: antagonizing functions for the prion protein PrPC and its homologue Dpl

2002 • 80 citations

PRP27–30Is a Normal Soluble Prion Protein Fragment Released by Human Platelets

1996 • 79 citations

Efficient Lymphoreticular Prion Propagation Requires PrP^cin Stromal and Hematopoietic Cells

2001 • 75 citations

Prion Protein Is Secreted in Soluble Forms in the Epididymal Fluid and Proteolytically Processed and Transported in Seminal Plasma1

2002 • 51 citations

Prions and the immune system

2001 • 2 citations