Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Nature of the Scrapie Agent: Self-replication and Scrapie

1967 • 1,128 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

A protease-resistant protein is a structural component of the Scrapie prion

1983 • 919 citations

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 • 874 citations

Cell-free formation of protease-resistant prion protein

1994 • 872 citations

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

1991 • 812 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Separation and properties of cellular and scrapie prion proteins.

1986 • 619 citations

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing

1993 • 578 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1991 • 412 citations

Linkage of prion protein and scrapie incubation time genes

1986 • 405 citations

Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells

1993 • 391 citations

Scrapie infectivity, fibrils and low molecular weight protein

1983 • 345 citations

Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells

1989 • 330 citations

The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).

1986 • 322 citations

Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture

1978 • 250 citations

Temporary and Permanent Modifications to a Single Strain of Mouse Scrapie on Transmission to Rats and Hamsters

1987 • 240 citations

Chimeric prion protein expression in cultured cells and transgenic mice

1992 • 240 citations

The Genomic Identity of Different Strains of Mouse Scrapie Is Expressed in Hamsters and Preserved on Reisolation in Mice

1989 • 222 citations

Linkage of the Scrapie-associated Fibril Protein (PrP) Gene and Sinc Using Congenic Mice and Restriction Fragment Length Polymorphism Analysis

1987 • 159 citations

Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells

1994 • 156 citations

Isolation and structural studies of the intact scrapie agent protein

1987 • 146 citations

Congo red inhibition of scrapie agent replication

1993 • 128 citations

The new biology of spongiform encephalopathy: infectious amyloidoses with a genetic twist

1991 • 124 citations

Normal and scrapie-associated forms of prion protein differ in their sensitivities to phospholipase and proteases in intact neuroblastoma cells

1990 • 118 citations

Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones

1988 • 115 citations

Novel infectious agents and the central nervous system.

1988 • 102 citations

Molecular location of a species-specific epitope on the hamster scrapie agent protein

1991 • 101 citations

A 60-kDa Prion Protein (PrP) with Properties of Both the Normal and Scrapie-associated Forms of PrP

1995 • 91 citations

Detection of Scrapie-associated Fibril (SAF) Proteins Using Anti-SAF Antibody in Non-purified Tissue Preparations

1986 • 90 citations

Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils.

1993 • 53 citations

Foreign PrP expression and scrapie infection in tissue culture cell lines.

1993 • 36 citations