Molecular Pathology of Pancreatic Cancer

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Tumor-suppressive pathways in pancreatic carcinoma.

1997 • 689 citations

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

1996 • 414 citations

MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase

1996 • 350 citations

Pancreatic adenocarcinomas frequently show p53 gene mutations.

1993 • 332 citations

Allelotype of pancreatic adenocarcinoma using xenograft enrichment.

1995 • 308 citations

Potential Tumor Suppressive Pathway Involving DUSP6/MKP-3 in Pancreatic Cancer

2003 • 209 citations

Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells

1998 • 158 citations

The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection

1999 • 158 citations

Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma

1997 • 125 citations

Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells

2003 • 105 citations

Varying grades of epithelial atypia in the pancreatic ducts of humans. Classification based on morphometry and multivariate analysis and correlated with positive reactions of carcinoembryonic antigen.

1994 • 82 citations

Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

1998 • 77 citations

Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: Identification of a 1-cM region of common allelic loss

1996 • 74 citations

Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer.

1998 • 63 citations

Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma

2000 • 59 citations

Loss of chromosome 18q is an early event in pancreatic ductal tumorigenesis.

1998 • 53 citations

Homozygous deletions inactivateDCC, but notMADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers

2000 • 45 citations

Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis

2001 • 41 citations

Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer

1999 • 36 citations

Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype.

2003 • 24 citations

Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines

2002 • 21 citations

Isolation and Characterization of the Human Gene Homologous to the Drosophila Headcase (hdc) Gene in Chromosome Bands 6q23-q24, a Region of Common Deletion in Human Pancreatic Cancer

2001 • 18 citations

REPRODUCIBLE CATEGORIZATION OF ATYPIA IN PANCREATIC DUCT EPITHELIA BASED ON MORPHOMETRY AND CLUSTER ANALYSIS, CORRELATINIG WITH CEAPOSITIVE REACTIONS AND Ki-ras GENE ALTERATIONS

1993 • 6 citations

Human BAC Contig Covering the Deleted Region in Pancreatic Cancer at 12q21

2001 • 5 citations

Reproducible categorization of atypia in pancratic duct epithelia based on morphometry and cluster analysis, correlating with CEA-positive reactions and Ki-ras gene alterations

1993 • 4 citations