Identification and characterization of cellular targets for tyrosine protein kinases.

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

High resolution two-dimensional electrophoresis of basic as well as acidic proteins

1977 • 3,556 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines.

1979 • 759 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus

1981 • 591 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product

1980 • 420 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

Characterization of Rous sarcoma virus src gene products synthesized in vitro

1978 • 352 citations

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.

1982 • 337 citations

Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine

1980 • 328 citations

Transformation by Rous sarcoma virus: effects of src gene expression on the synthesis and phosphorylation of cellular polypeptides.

1979 • 293 citations

Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

1981 • 277 citations

Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo

1978 • 229 citations

Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells

1977 • 222 citations

Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten

1981 • 203 citations

Efficient fluorography of 3H and 14C on thin layers

1978 • 190 citations

Four Different Classes of Retroviruses Induce Phosphorylation of Tyrosines Present in Similar Cellular Proteins

1981 • 178 citations

Polyoma virus proteins: A description of the structural proteins of the virion based on polyacrylamide gel electrophoresis and peptide analysis

1974 • 175 citations

Detection of phosphotyrosine-containing 34,000-dalton protein in the framework of cells transformed with Rous sarcoma virus.

1981 • 149 citations

Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase

1981 • 126 citations

Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine

1981 • 80 citations

Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts.

1982 • 73 citations

Bacterial expression of an enzymatically active protein encoded by RSV src gene

1982 • 66 citations

The same normal cell protein is phosphorylated after transformation by avian sarcoma viruses with unrelated transforming genes.

1981 • 63 citations

Gel isoelectric focusing for following the successive carbamylations of amino groups in chymotrypsinogen A

1971 • 51 citations

Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.

1982 • 41 citations

Identification of a Packaged Cellular mRNA in Virions of Rous Sarcoma Virus

1981 • 31 citations

Some lymphoid cell lines transformed by Abelson murine leukemia virus lack a major 36,000-dalton tyrosine protein kinase substrate.

1983 • 27 citations

Phosphoprotein associated with activation of the src gene product in myogenic cells

1980 • 22 citations